Introduction: Epigenomic datasets from high-throughput sequencing experiments are commonly summarized as genomic intervals. As the volume of this data grows, so does interest in analyzing it through deep learning. However, the heterogeneity of genomic interval data, where each dataset defines its own regions, creates barriers for machine learning methods that require consistent, discrete vocabularies. Methods: We introduce gtars-tokenizers, a high-performance library that maps genomic intervals to a predefined universe or vocabulary of regions, analogous to text tokenization in natural language processing. Built in Rust with bindings for Python, R, CLI, and WebAssembly, gtars-tokenizers implements two overlap methods (BITS and AIList) and integrates seamlessly with modern ML frameworks through Hugging Face-compatible APIs. Results: The gtars-tokenizers package achieves top efficiency for large-scale datasets, while enabling genomic intervals to be processed using standard ML workflows in PyTorch and TensorFlow without ad hoc preprocessing. This token-based approach bridges genomics and machine learning, supporting scalable and standardized analysis of interval data across diverse computational environments. Availability: PyPI and GitHub: https://github.com/databio/gtars.

Recent advances in large language models (LLMs) and autonomous agents have enabled systems capable of performing complex tasks across domains such as human-computer interaction, planning, and web navigation. However, many existing frameworks struggle in real-world or resource-constrained environments due to their reliance on cloud-based computation, limited robustness in dynamic contexts, and lack of persistent autonomy and environmental awareness. We present Amico, a modular, event-driven framework for building autonomous agents optimized for embedded systems. Written in Rust for safety and performance, Amico supports reactive, persistent agents that operate efficiently across embedded platforms and browser environments via WebAssembly. It provides clean abstractions for event handling, state management, behavior execution, and integration with reasoning modules. Amico delivers a unified infrastructure for constructing resilient, interactive agents suitable for deployment in settings with limited compute and intermittent connectivity.

Advancements in large language models (LLMs) have unlocked remarkable capabilities. While deploying these models typically requires server-grade GPUs and cloud-based inference, the recent emergence of smaller open-source models and increasingly powerful consumer devices have made on-device deployment practical. The web browser as a platform for on-device deployment is universally accessible, provides a natural agentic environment, and conveniently abstracts out the different backends from diverse device vendors. To address this opportunity, we introduce WebLLM, an open-source JavaScript framework that enables high-performance LLM inference entirely within web browsers. WebLLM provides an OpenAI-style API for seamless integration into web applications, and leverages WebGPU for efficient local GPU acceleration and WebAssembly for performant CPU computation. With machine learning compilers MLC-LLM and Apache TVM, WebLLM leverages optimized WebGPU kernels, overcoming the absence of performant WebGPU kernel libraries. Evaluations show that WebLLM can retain up to 80% native performance on the same device, with room to further close the gap. WebLLM paves the way for universally accessible, privacy-preserving, personalized, and locally powered LLM applications in web browsers. The code is available at: https://github.com/mlc-ai/web-llm.

The Robot Operating System (ROS) has become the de facto standard middleware in robotics, widely adopted across domains ranging from education to industrial applications. The RoboStack distribution has extended ROS's accessibility by facilitating installation across all major operating systems and architectures, integrating seamlessly with scientific tools such as PyTorch and Open3D. This paper presents ROS2WASM, a novel integration of RoboStack with WebAssembly, enabling the execution of ROS 2 and its associated software directly within web browsers, without requiring local installations. This approach significantly enhances reproducibility and shareability of research, lowers barriers to robotics education, and leverages WebAssembly's robust security framework to protect against malicious code. We detail our methodology for cross-compiling ROS 2 packages into WebAssembly, the development of a specialized middleware for ROS 2 communication within browsers, and the implementation of a web platform available at www.ros2wasm.dev that allows users to interact with ROS 2 environments. Additionally, we extend support to the Robotics Toolbox for Python and adapt its Swift simulator for browser compatibility. Our work paves the way for unprecedented accessibility in robotics, offering scalable, secure, and reproducible environments that have the potential to transform educational and research paradigms.

WebAssembly enables near-native execution in web applications and is increasingly adopted for tasks that demand high performance and robust security. However, its assembly-like syntax, implicit stack machine, and low-level data types make it extremely difficult for human developers to understand, spurring the need for effective WebAssembly reverse engineering techniques. In this paper, we propose StackSight, a novel neurosymbolic approach that combines Large Language Models (LLMs) with advanced program analysis to decompile complex WebAssembly code into readable C++ snippets. StackSight visualizes and tracks virtual stack alterations via a static analysis algorithm and then applies chain-of-thought prompting to harness LLM's complex reasoning capabilities. Evaluation results show that StackSight significantly improves WebAssembly decompilation. Our user study also demonstrates that code snippets generated by StackSight have significantly higher win rates and enable a better grasp of code semantics.

The increasing adoption of WebAssembly (Wasm) for performance-critical and security-sensitive tasks drives the demand for WebAssembly program comprehension and reverse engineering. Recent studies have introduced machine learning (ML)-based WebAssembly reverse engineering tools. Yet, the generalization of task-specific ML solutions remains challenging, because their effectiveness hinges on the availability of an ample supply of high-quality task-specific labeled data. Moreover, previous works overlook the high-level semantics present in source code and its documentation. Acknowledging the abundance of available source code with documentation, which can be compiled into WebAssembly, we propose to learn representations of them concurrently and harness their mutual relationships for effective WebAssembly reverse engineering. In this paper, we present WasmRev, the first multi-modal pre-trained language model for WebAssembly reverse engineering. WasmRev is pre-trained using self-supervised learning on a large-scale multi-modal corpus encompassing source code, code documentation and the compiled WebAssembly, without requiring labeled data. WasmRev incorporates three tailored multi-modal pre-training tasks to capture various characteristics of WebAssembly and cross-modal relationships. WasmRev is only trained once to produce general-purpose representations that can broadly support WebAssembly reverse engineering tasks through few-shot fine-tuning with much less labeled data, improving data efficiency. We fine-tune WasmRev onto three important reverse engineering tasks: type recovery, function purpose identification and WebAssembly summarization. Our results show that WasmRev pre-trained on the corpus of multi-modal samples establishes a robust foundation for these tasks, achieving high task accuracy and outperforming the state-of-the-art ML methods for WebAssembly reverse engineering.

Machine learning is often used for malicious website detection, but an approach incorporating WebAssembly as a feature has not been explored due to a limited number of samples, to the best of our knowledge. In this paper, we propose JABBERWOCK (JAvascript-Based Binary EncodeR by WebAssembly Optimization paCKer), a tool to generate WebAssembly datasets in a pseudo fashion via JavaScript. Loosely speaking, JABBERWOCK automatically gathers JavaScript code in the real world, convert them into WebAssembly, and then outputs vectors of the WebAssembly as samples for malicious website detection. We also conduct experimental evaluations of JABBERWOCK in terms of the processing time for dataset generation, comparison of the generated samples with actual WebAssembly samples gathered from the Internet, and an application for malicious website detection. Regarding the processing time, we show that JABBERWOCK can construct a dataset in 4.5 seconds per sample for any number of samples. Next, comparing 10,000 samples output by JABBERWOCK with 168 gathered WebAssembly samples, we believe that the generated samples by JABBERWOCK are similar to those in the real world. We then show that JABBERWOCK can provide malicious website detection with 99\% F1-score because JABBERWOCK makes a gap between benign and malicious samples as the reason for the above high score. We also confirm that JABBERWOCK can be combined with an existing malicious website detection tool to improve F1-scores. JABBERWOCK is publicly available via GitHub (https://github.com/c-chocolate/Jabberwock).

Google recently announced ways to blur and replace the background in Google Meet for better focus on the person rather than the surrounding. The new features are powered by cutting-edge web machine learning (ML) technologies built with MediaPipe that work directly in the browser, without any extra steps like installing additional software. One of the main motives for developing these features was to provide real-time, in-browser performance on almost all modern devices. It accomplishes this by combining efficient on-device ML models, WebGL-based rendering, and web-based ML inference via XNNPACK and TFLite. The new features of Meet are developed with MediaPipe, Google's open-source framework. It helps building multimodal (for example, video, audio, any time series data), cross-platform (i.e., Android, iOS, web, edge devices) applied ML pipelines.

The rumours that AI (and ML) will revolutionise healthcare have been around for a while [1]. And yes, we have seen some amazing uses of AI in healthcare [see, e.g., 2,3]. But, in my personal experience, the majority of the models trained in healthcare never make it to practice. Let's see why (or, scroll down and see how we solve it). Note: The statement "the majority of the models trained in … never make it to practice" is probably true across disciplines. Healthcare happens to be the one I am sure about.