ABSTRACT In this paper, we present a novel system that separates the voice of a target speaker from multi-speaker signals, by making use of a reference signal from the target speaker. We achieve this by training two separate neural networks: (1) A speaker recognition network that produces speaker-discriminative embeddings; (2) A spectrogram masking network that takes both noisy spectrogram and speaker embedding as input, and produces a mask. Our system significantly reduces the speech recognition WER on multi-speaker signals, with minimal WER degradation on single-speaker signals. Index Terms-- Source separation, speaker recognition, spectrogram masking, speech recognition 1. INTRODUCTION Recent advances in speech recognition have led to performance improvement in challenging scenarios such as noisy and far-field conditions. However, speech recognition systems still perform poorly when the speaker of interest is recorded in crowded environments, i.e., with interfering speakers in the foreground or background. One way to deal with this issue is to first apply a speech separation system on the noisy audio in order to separate the voices from different speakers.