Many natural dynamic processes -- such as in vivo cellular differentiation or disease progression -- can only be observed through the lens of static sample snapshots. While challenging, reconstructing their temporal evolution to decipher underlying dynamic properties is of major interest to scientific research. Existing approaches enable data transport along a temporal axis but are poorly scalable in high dimension and require restrictive assumptions to be met. To address these issues, we propose Multi-Marginal temporal Schrödinger Bridge Matching (MMtSBM) from unpaired data, extending the theoretical guarantees and empirical efficiency of Diffusion Schrödinger Bridge Matching (arXiv:2303.16852) by deriving the Iterative Markovian Fitting algorithm to multiple marginals in a novel factorized fashion. Experiments show that MMtSBM retains theoretical properties on toy examples, achieves state-of-the-art performance on real-world datasets such as transcriptomic trajectory inference in 100 dimensions, and, for the first time, recovers couplings and dynamics in very high-dimensional image settings. Our work establishes multi-marginal Schrödinger bridges as a practical and principled approach for recovering hidden dynamics from static data.

Traditional multimodal learners find unified representations for tasks like visual question answering, but rely heavily on paired datasets. However, an overlooked yet potentially powerful question is: can one leverage auxiliary unpaired multimodal data to directly enhance representation learning in a target modality? We introduce UML: Unpaired Multimodal Learner, a modality-agnostic training paradigm in which a single model alternately processes inputs from different modalities while sharing parameters across them. This design exploits the assumption that different modalities are projections of a shared underlying reality, allowing the model to benefit from cross-modal structure without requiring explicit pairs. Theoretically, under linear data-generating assumptions, we show that unpaired auxiliary data can yield representations strictly more informative about the data-generating process than unimodal training. Empirically, we show that using unpaired data from auxiliary modalities -- such as text, audio, or images -- consistently improves downstream performance across diverse unimodal targets such as image and audio. Our project page: https://unpaired-multimodal.github.io/

Expressive performance rendering (EPR) and automatic piano transcription (APT) are fundamental yet inverse tasks in music information retrieval: EPR generates expressive performances from symbolic scores, while APT recovers scores from performances. Despite their dual nature, prior work has addressed them independently. In this paper we propose a unified framework that jointly models EPR and APT by disentangling note-level score content and global performance style representations from both paired and unpaired data. Our framework is built on a transformer-based sequence-to-sequence architecture and is trained using only sequence-aligned data, without requiring fine-grained note-level alignment. To automate the rendering process while ensuring stylistic compatibility with the score, we introduce an independent diffusion-based performance style recommendation module that generates style embeddings directly from score content. This modular component supports both style transfer and flexible rendering across a range of expressive styles. Experimental results from both objective and subjective evaluations demonstrate that our framework achieves competitive performance on EPR and APT tasks, while enabling effective content-style disentanglement, reliable style transfer, and stylistically appropriate rendering. Demos are available at https://jointpianist.github.io/epr-apt/

With the rapid advancement of deep learning, particularly through generative adversarial networks (GANs) and diffusion models (DMs), AI-generated images, or ``deepfakes", have become nearly indistinguishable from real ones. These images are widely shared across Online Social Networks (OSNs), raising concerns about their misuse. Existing deepfake detection methods overlook the ``block effects" introduced by compression in OSNs, which obscure deepfake artifacts, and primarily focus on raw images, rarely encountered in real-world scenarios. To address these challenges, we propose PLADA (Pay Less Attention to Deceptive Artifacts), a novel framework designed to tackle the lack of paired data and the ineffective use of compressed images. PLADA consists of two core modules: Block Effect Eraser (B2E), which uses a dual-stage attention mechanism to handle block effects, and Open Data Aggregation (ODA), which processes both paired and unpaired data to improve detection. Extensive experiments across 26 datasets demonstrate that PLADA achieves a remarkable balance in deepfake detection, outperforming SoTA methods in detecting deepfakes on OSNs, even with limited paired data and compression. More importantly, this work introduces the ``block effect" as a critical factor in deepfake detection, providing a robust solution for open-world scenarios. Our code is available at https://github.com/ManyiLee/PLADA.

Learning shared representations is a primary area of multimodal representation learning. The current approaches to achieve a shared embedding space rely heavily on paired samples from each modality, which are significantly harder to obtain than unpaired ones. In this work, we demonstrate that shared representations can be learned almost exclusively from unpaired data. Our arguments are grounded in the spectral embeddings of the random walk matrices constructed independently from each unimodal representation. Empirical results in computer vision and natural language processing domains support its potential, revealing the effectiveness of unpaired data in capturing meaningful cross-modal relations, demonstrating high capabilities in retrieval tasks, generation, arithmetics, zero-shot, and cross-domain classification. This work, to the best of our knowledge, is the first to demonstrate these capabilities almost exclusively from unpaired samples, giving rise to a cross-modal embedding that could be viewed as universal, i.e., independent of the specific modalities of the data. Our code IS publicly available at https://github.com/shaham-lab/SUE.

Low-cost accelerometers play a crucial role in modern society due to their advantages of small size, ease of integration, wearability, and mass production, making them widely applicable in automotive systems, aerospace, and wearable technology. However, this widely used sensor suffers from severe accuracy and range limitations. To this end, we propose a honed-energy regularized and optimal supervised GAN (HEROS-GAN), which transforms low-cost sensor signals into high-cost equivalents, thereby overcoming the precision and range limitations of low-cost accelerometers. Due to the lack of frame-level paired low-cost and high-cost signals for training, we propose an Optimal Transport Supervision (OTS), which leverages optimal transport theory to explore potential consistency between unpaired data, thereby maximizing supervisory information. Moreover, we propose a Modulated Laplace Energy (MLE), which injects appropriate energy into the generator to encourage it to break range limitations, enhance local changes, and enrich signal details. Given the absence of a dedicated dataset, we specifically establish a Low-cost Accelerometer Signal Enhancement Dataset (LASED) containing tens of thousands of samples, which is the first dataset serving to improve the accuracy and range of accelerometers and is released in Github. Experimental results demonstrate that a GAN combined with either OTS or MLE alone can surpass the previous signal enhancement SOTA methods by an order of magnitude. Integrating both OTS and MLE, the HEROS-GAN achieves remarkable results, which doubles the accelerometer range while reducing signal noise by two orders of magnitude, establishing a benchmark in the accelerometer signal processing.

Learning conditional distributions $\pi^*(\cdot|x)$ is a central problem in machine learning, which is typically approached via supervised methods with paired data $(x,y) \sim \pi^*$. However, acquiring paired data samples is often challenging, especially in problems such as domain translation. This necessitates the development of $\textit{semi-supervised}$ models that utilize both limited paired data and additional unpaired i.i.d. samples $x \sim \pi^*_x$ and $y \sim \pi^*_y$ from the marginal distributions. The usage of such combined data is complex and often relies on heuristic approaches. To tackle this issue, we propose a new learning paradigm that integrates both paired and unpaired data $\textbf{seamlessly}$ through the data likelihood maximization techniques. We demonstrate that our approach also connects intriguingly with inverse entropic optimal transport (OT). This finding allows us to apply recent advances in computational OT to establish a $\textbf{light}$ learning algorithm to get $\pi^*(\cdot|x)$. Furthermore, we demonstrate through empirical tests that our method effectively learns conditional distributions using paired and unpaired data simultaneously.

Visual acoustic matching (VAM) is pivotal for enhancing the immersive experience, and the task of dereverberation is effective in improving audio intelligibility. Existing methods treat each task independently, overlooking the inherent reciprocity between them. Moreover, these methods depend on paired training data, which is challenging to acquire, impeding the utilization of extensive unpaired data. In this paper, we introduce MVSD, a mutual learning framework based on diffusion models. MVSD considers the two tasks symmetrically, exploiting the reciprocal relationship to facilitate learning from inverse tasks and overcome data scarcity. Furthermore, we employ the diffusion model as foundational conditional converters to circumvent the training instability and over-smoothing drawbacks of conventional GAN architectures. Specifically, MVSD employs two converters: one for VAM called reverberator and one for dereverberation called dereverberator. The dereverberator judges whether the reverberation audio generated by reverberator sounds like being in the conditional visual scenario, and vice versa. By forming a closed loop, these two converters can generate informative feedback signals to optimize the inverse tasks, even with easily acquired one-way unpaired data. Extensive experiments on two standard benchmarks, i.e., SoundSpaces-Speech and Acoustic AVSpeech, exhibit that our framework can improve the performance of the reverberator and dereverberator and better match specified visual scenarios.

Retrosynthesis, the process of identifying precursors for a target molecule, is essential for material design and drug discovery (Blakemore et al, 2018). However, the huge search space for possible chemical transformations and enormous time required even for experts make this challenging. Thus, efficient computerassisted synthesis (Corey and Wipke, 1969; Corey et al, 1985; Coley et al, 2017) has been explored for long periods. Thanks to recent advances in artificial intelligence, machine learning (ML)-based methods (Segler et al, 2018; Mikulak-Klucznik et al, 2020; Schwaller et al, 2021; Toniato et al, 2021; Yu et al, 2023; Born and Manica, 2023) have emerged to assist chemists to design experiments and gain insights that might not be solely achievable through traditional methods, bringing retrosynthesis research to a new pivotal moment. The ML-based methods for single-step retrosynthesis can be roughly categorized into three groups: Template-based methods predict reactants using reaction templates that encode core reactive rules. LHASA (Corey et al, 1985), the first retrosynthesis program, utilizes manual-encoding templates to predict retrosynthetic routes. To scale to exponentially growing knowledge (Segler et al, 2018), data-driven methods (Segler and Waller, 2017; Coley et al, 2017; Dai et al, 2019; Baylon et al, 2019; Chen and Jung, 2021) extract a large number of reaction templates from data and formulate retrosynthesis as a template retrieval/classification task. Semi-template methods (Shi et al, 2020; Yan et al, 2020; Somnath et al, 2021; Wang et al, 2021) decompose retrosynthesis into two stages: they typically (1) identify the reactive sites to convert the product into synthons and (2) complete the synthons into reactant(s), which utilize "reaction centers" in templates to supervise the training procedure (Sun et al, 2021). Template-free methods view single-step retrosynthesis prediction as a machine translation task, where deep generative models directly translate the given product into reactant(s).

On shopping websites, product images of low quality negatively affect customer experience. Although there are plenty of work in detecting images with different defects, few efforts have been dedicated to correct those defects at scale. A major challenge is that there are thousands of product types and each has specific defects, therefore building defect specific models is unscalable. In this paper, we propose a unified Image-to-Image (I2I) translation model to correct multiple defects across different product types. Our model leverages an attention mechanism to hierarchically incorporate high-level defect groups and specific defect types to guide the network to focus on defect-related image regions. Evaluated on eight public datasets, our model reduces the Frechet Inception Distance (FID) by 24.6% in average compared with MoNCE, the state-of-the-art I2I method. Unlike public data, another practical challenge on shopping websites is that some paired images are of low quality. Therefore we design our model to be semi-paired by combining the L1 loss of paired data with the cycle loss of unpaired data. Tested on a shopping website dataset to correct three image defects, our model reduces (FID) by 63.2% in average compared with WS-I2I, the state-of-the art semi-paired I2I method.