Speckle patterns in ultrasound images often obscure anatomical details, leading to diagnostic uncertainty. Recently, various deep learning (DL)-based techniques have been introduced to effectively suppress speckle; however, their high computational costs pose challenges for low-resource devices, such as portable ultrasound systems. To address this issue, EdgeSRIE, which is a lightweight hybrid DL framework for real-time speckle reduction and image enhancement in portable ultrasound imaging, is introduced. The proposed framework consists of two main branches: an unsupervised despeckling branch, which is trained by minimizing a loss function between speckled images, and a deblurring branch, which restores blurred images to sharp images. For hardware implementation, the trained network is quantized to 8-bit integer precision and deployed on a low-resource system-on-chip (SoC) with limited power consumption. In the performance evaluation with phantom and in vivo analyses, EdgeSRIE achieved the highest contrast-to-noise ratio (CNR) and average gradient magnitude (AGM) compared with the other baselines (different 2-rule-based methods and other 4-DL-based methods). Furthermore, EdgeSRIE enabled real-time inference at over 60 frames per second while satisfying computational requirements (< 20K parameters) on actual portable ultrasound hardware. These results demonstrated the feasibility of EdgeSRIE for real-time, high-quality ultrasound imaging in resource-limited environments.

Exo, pronounced "echo," raised a fresh cash infusion of $220 million in Series C financing aimed at commercializing its handheld ultrasound device and point-of-care workflow platform, Exo Works. The round was led by RA Capital Management, while BlackRock, Sands Capital, Avidity Partners, Pura Vida Investments and prior investors joined in. The new funding gives the Redwood City, California-based company over $320 million in total investments since the company was founded in 2015, Exo CEO Sandeep Akkaraju told TechCrunch. This includes a $40 million investment raised in 2020. Ultrasound machines can cost anywhere from $40,000 to $250,000 for low-end technology and into the millions for high-end machines.

Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). These are just some of the innovations now transforming medicine at a remarkable pace. No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medical science likely to come in the 2020s.

With tech giants pouring billions of dollars into artificial intelligence projects, it's hard to see how startups can find their place and create successful business models that leverage AI. However, while fiercely competitive, the AI space is also constantly causing fundamental shifts in many sectors. And this creates the perfect environment for fast-thinking and -moving startups to carve a niche for themselves before the big players move in. Last week, technology analysis firm CB Insights published an update on the status of its list of top 100 AI startups of 2020 (in case you don't know, CB Insight publishes a list of 100 most promising AI startups every year). Out of the hundred startups, four have made exits, with three going public and one being acquired by Facebook.

This morning AI-enabled handheld ultrasound startup Exo landed $35 million in Series B funding. The new infusion of cash was led by Intel Capital with participation from Applied Ventures, Bold Capital, Creative Ventures, Longevity Vision Fund, Magnetar Capital, Nautilus Venture Partners, OSF Healthcare, Rising Tide Fund, Sony Innovation Fund and Wanxiang Healthcare Investments. The Redwood City, California-based startup is developing a portable ultrasound that is able to create a 3D image. The company is combining nano-materials, sensor technology and advanced signal processing and computation to create the technology. The new money will be put towards developing the product and helping the startup go through regulatory channels.

Medical ultrasound technology is widely used in routine clinical applications such as disease diagnosis and treatment as well as other applications like real-time monitoring of human tongue shapes and motions as visual feedback in second language training. Due to the low-contrast characteristic and noisy nature of ultrasound images, it might require expertise for non-expert users to recognize tongue gestures. Manual tongue segmentation is a cumbersome, subjective, and error-prone task. Furthermore, it is not a feasible solution for real-time applications. In the last few years, deep learning methods have been used for delineating and tracking tongue dorsum. Deep convolutional neural networks (DCNNs), which have shown to be successful in medical image analysis tasks, are typically weak for the same task on different domains. In many cases, DCNNs trained on data acquired with one ultrasound device, do not perform well on data of varying ultrasound device or acquisition protocol. Domain adaptation is an alternative solution for this difficulty by transferring the weights from the model trained on a large annotated legacy dataset to a new model for adapting on another different dataset using fine-tuning. In this study, after conducting extensive experiments, we addressed the problem of domain adaptation on small ultrasound datasets for tongue contour extraction. We trained a U-net network comprises of an encoder-decoder path from scratch, and then with several surrogate scenarios, some parts of the trained network were fine-tuned on another dataset as the domain-adapted networks. We repeat scenarios from target to source domains to find a balance point for knowledge transfer from source to target and vice versa. The performance of new fine-tuned networks was evaluated on the same task with images from different domains.