Fluorodeoxyglucose (FDG) PET to evaluate patients with epilepsy is one of the most common applications for simultaneous PET/MRI, given the need to image both brain structure and metabolism, but is suboptimal due to the radiation dose in this young population. Little work has been done synthesizing diagnostic quality PET images from MRI data or MRI data with ultralow-dose PET using advanced generative AI methods, such as diffusion models, with attention to clinical evaluations tailored for the epilepsy population. Here we compared the performance of diffusion- and non-diffusion-based deep learning models for the MRI-to-PET image translation task for epilepsy imaging using simultaneous PET/MRI in 52 subjects (40 train/2 validate/10 hold-out test). We tested three different models: 2 score-based generative diffusion models (SGM-Karras Diffusion [SGM-KD] and SGM-variance preserving [SGM-VP]) and a Transformer-Unet. We report results on standard image processing metrics as well as clinically relevant metrics, including congruency measures (Congruence Index and Congruency Mean Absolute Error) that assess hemispheric metabolic asymmetry, which is a key part of the clinical analysis of these images. The SGM-KD produced the best qualitative and quantitative results when synthesizing PET purely from T1w and T2 FLAIR images with the least mean absolute error in whole-brain specific uptake value ratio (SUVR) and highest intraclass correlation coefficient. When 1% low-dose PET images are included in the inputs, all models improve significantly and are interchangeable for quantitative performance and visual quality. In summary, SGMs hold great potential for pure MRI-to-PET translation, while all 3 model types can synthesize full-dose FDG-PET accurately using MRI and ultralow-dose PET.

Cone-beam computed tomography (CBCT) using only a few X-ray projection views enables faster scans with lower radiation dose, but the resulting severe under-sampling causes strong artifacts and poor spatial coverage. We address these challenges in a unified framework. First, we replace conventional UNet/ResNet encoders with TransUNet, a hybrid CNN-Transformer model. Convolutional layers capture local details, while self-attention layers enhance global context. We adapt TransUNet to CBCT by combining multi-scale features, querying view-specific features per 3D point, and adding a lightweight attenuation-prediction head. This yields Trans-CBCT, which surpasses prior baselines by 1.17 dB PSNR and 0.0163 SSIM on the LUNA16 dataset with six views. Second, we introduce a neighbor-aware Point Transformer to enforce volumetric coherence. This module uses 3D positional encoding and attention over k-nearest neighbors to improve spatial consistency. The resulting model, Trans$^2$-CBCT, provides an additional gain of 0.63 dB PSNR and 0.0117 SSIM. Experiments on LUNA16 and ToothFairy show consistent gains from six to ten views, validating the effectiveness of combining CNN-Transformer features with point-based geometry reasoning for sparse-view CBCT reconstruction.

Accurate segmentation is essential for effective treatment planning and disease monitoring. Existing medical image segmentation methods predominantly rely on uni-modal visual inputs, such as images or videos, requiring labor-intensive manual annotations. Additionally, medical imaging techniques capture multiple intertwined organs within a single scan, further complicating segmentation accuracy. To address these challenges, MedSAM, a large-scale medical segmentation model based on the Segment Anything Model (SAM), was developed to enhance segmentation accuracy by integrating image features with user-provided prompts. While MedSAM has demonstrated strong performance across various medical segmentation tasks, it primarily relies on geometric prompts (e.g., points and bounding boxes) and lacks support for text-based prompts, which could help specify subtle or ambiguous anatomical structures. To overcome these limitations, we propose the Organ-aware Multi-scale Text-guided Medical Image Segmentation Model (OMT-SAM) for multi-organ segmentation. Our approach introduces CLIP encoders as a novel image-text prompt encoder, operating with the geometric prompt encoder to provide informative contextual guidance. We pair descriptive textual prompts with corresponding images, processing them through pre-trained CLIP encoders and a cross-attention mechanism to generate fused image-text embeddings. Additionally, we extract multi-scale visual features from MedSAM, capturing fine-grained anatomical details at different levels of granularity. We evaluate OMT-SAM on the FLARE 2021 dataset, benchmarking its performance against existing segmentation methods. Empirical results demonstrate that OMT-SAM achieves a mean Dice Similarity Coefficient of 0.937, outperforming MedSAM (0.893) and other segmentation models, highlighting its superior capability in handling complex medical image segmentation tasks.

Fetal gestational age (GA) is vital clinical information that is estimated during pregnancy in order to assess fetal growth. This is usually performed by measuring the crown-rump-length (CRL) on an ultrasound image in the Dating scan which is then correlated with fetal age and growth trajectory. A major issue when performing the CRL measurement is ensuring that the image is acquired at the correct view, otherwise it could be misleading. Although clinical guidelines specify the criteria for the correct CRL view, sonographers may not regularly adhere to such rules. In this paper, we propose a new deep learning-based solution that is able to verify the adherence of a CRL image to clinical guidelines in order to assess image quality and facilitate accurate estimation of GA. We first segment out important fetal structures then use the localized structures to perform a clinically-guided mapping that verifies the adherence of criteria. The segmentation method combines the benefits of Convolutional Neural Network (CNN) and the Vision Transformer (ViT) to segment fetal structures in ultrasound images and localize important fetal landmarks. For segmentation purposes, we compare our proposed work with UNet and show that our CNN/ViT-based method outperforms an optimized version of UNet. Furthermore, we compare the output of the mapping with classification CNNs when assessing the clinical criteria and the overall acceptability of CRL images. We show that the proposed mapping is not only explainable but also more accurate than the best performing classification CNNs.

Medical image segmentation is a crucial task in medical image processing. Thanks to the advent of CNN[12], U-Net [17], and their variants such as V-Net[14], 3D U-Net[5], Res-UNet[15], Dense-UNet[13], we are able to perform segmentation task with precision. More recently, with implementations of transformer-based models, the medical imaging community enjoyed satisfying success in segmentation tasks. Networks like Medical Transformers[18] and SwinUnet[1] push the front-line boundary to another degree. Others have implemented learning methodologies from other fields, such as dictionary learning, to work on medical images. KEN[16] - knowledge embedding network - for example, takes advantage of the fruitfulness of information embedding in each layer via dictionary learning to provide a more semantically meaningful network.

Deep learning has demonstrated remarkable achievements in medical image segmentation. However, prevailing deep learning models struggle with poor generalization due to (i) intra-class variations, where the same class appears differently in different samples, and (ii) inter-class independence, resulting in difficulties capturing intricate relationships between distinct objects, leading to higher false negative cases. This paper presents a novel approach that synergies spatial and spectral representations to enhance domain-generalized medical image segmentation. We introduce the innovative Spectral Correlation Coefficient objective to improve the model's capacity to capture middle-order features and contextual long-range dependencies. This objective complements traditional spatial objectives by incorporating valuable spectral information. Extensive experiments reveal that optimizing this objective with existing architectures like UNet and TransUNet significantly enhances generalization, interpretability, and noise robustness, producing more confident predictions. For instance, in cardiac segmentation, we observe a 0.81 pp and 1.63 pp (pp = percentage point) improvement in DSC over UNet and TransUNet, respectively. Our interpretability study demonstrates that, in most tasks, objectives optimized with UNet outperform even TransUNet by introducing global contextual information alongside local details. These findings underscore the versatility and effectiveness of our proposed method across diverse imaging modalities and medical domains.

Most state-of-the-art methods for medical image segmentation adopt the encoder-decoder architecture. However, this U-shaped framework still has limitations in capturing the non-local multi-scale information with a simple skip connection. To solve the problem, we firstly explore the potential weakness of skip connections in U-Net on multiple segmentation tasks, and find that i) not all skip connections are useful, each skip connection has different contribution; ii) the optimal combinations of skip connections are different, relying on the specific datasets. Based on our findings, we propose a new segmentation framework, named UDTransNet, to solve three semantic gaps in U-Net. Specifically, we propose a Dual Attention Transformer (DAT) module for capturing the channel- and spatial-wise relationships to better fuse the encoder features, and a Decoder-guided Recalibration Attention (DRA) module for effectively connecting the DAT tokens and the decoder features to eliminate the inconsistency. Hence, both modules establish a learnable connection to solve the semantic gaps between the encoder and the decoder, which leads to a high-performance segmentation model for medical images. Comprehensive experimental results indicate that our UDTransNet produces higher evaluation scores and finer segmentation results with relatively fewer parameters over the state-of-the-art segmentation methods on different public datasets. Code: https://github.com/McGregorWwww/UDTransNet.

Large models and enormous data are essential driving forces of the unprecedented successes achieved by modern algorithms, especially in scientific computing and machine learning. Nevertheless, the growing dimensionality and model complexity, as well as the non-negligible workload of data pre-processing, also bring formidable costs to such successes in both computation and data aggregation. As the deceleration of Moore's Law slackens the cost reduction of computation from the hardware level, fast heuristics for expensive classical routines and efficient algorithms for exploiting limited data are increasingly indispensable for pushing the limit of algorithm potency. This thesis explores some of such algorithms for fast execution and efficient data utilization. From the computational efficiency perspective, we design and analyze fast randomized low-rank decomposition algorithms for large matrices based on "matrix sketching", which can be regarded as a dimension reduction strategy in the data space. These include the randomized pivoting-based interpolative and CUR decomposition discussed in Chapter 2 and the randomized subspace approximations discussed in Chapter 3. From the sample efficiency perspective, we focus on learning algorithms with various incorporations of data augmentation that improve generalization and distributional robustness provably. Specifically, Chapter 4 presents a sample complexity analysis for data augmentation consistency regularization where we view sample efficiency from the lens of dimension reduction in the function space. Then in Chapter 5, we introduce an adaptively weighted data augmentation consistency regularization algorithm for distributionally robust optimization with applications in medical image segmentation.

Subsurface tile drainage pipes provide agronomic, economic and environmental benefits. By lowering the water table of wet soils, they improve the aeration of plant roots and ultimately increase the productivity of farmland. They do however also provide an entryway of agrochemicals into subsurface water bodies and increase nutrition loss in soils. For maintenance and infrastructural development, accurate maps of tile drainage pipe locations and drained agricultural land are needed. However, these maps are often outdated or not present. Different remote sensing (RS) image processing techniques have been applied over the years with varying degrees of success to overcome these restrictions. Recent developments in deep learning (DL) techniques improve upon the conventional techniques with machine learning segmentation models. In this study, we introduce two DL-based models: i) improved U-Net architecture; and ii) Visual Transformer-based encoder-decoder in the framework of tile drainage pipe detection. Experimental results confirm the effectiveness of both models in terms of detection accuracy when compared to a basic U-Net architecture.

Originally published on Towards AI the World's Leading AI and Technology News and Media Company. If you are building an AI-related product or service, we invite you to consider becoming an AI sponsor. At Towards AI, we help scale AI and technology startups. Let us help you unleash your technology to the masses. Nowadays, U-Net has dominated image segmentation tasks, especially in the field of medical imaging.