Pose-Guided Person Image Synthesis (PGPIS) generates images that maintain a subject's identity from a source image while adopting a specified target pose (e.g., skeleton). While diffusion-based PGPIS methods effectively preserve facial features during pose transformation, they often struggle to accurately maintain clothing details from the source image throughout the diffusion process. This limitation becomes particularly problematic when there is a substantial difference between the source and target poses, significantly impacting PGPIS applications in the fashion industry where clothing style preservation is crucial for copyright protection. Our analysis reveals that this limitation primarily stems from the conditional diffusion model's attention modules failing to adequately capture and preserve clothing patterns. To address this limitation, we propose human-parsing-guided attention diffusion, a novel approach that effectively preserves both facial and clothing appearance while generating high-quality results. We propose a human-parsing-aware Siamese network that consists of three key components: dual identical UNets (TargetNet for diffusion denoising and SourceNet for source image embedding extraction), a human-parsing-guided fusion attention (HPFA), and a CLIP-guided attention alignment (CAA). The HPFA and CAA modules can embed the face and clothes patterns into the target image generation adaptively and effectively. Extensive experiments on both the in-shop clothes retrieval benchmark and the latest in-the-wild human editing dataset demonstrate our method's significant advantages over 13 baseline approaches for preserving both facial and clothes appearance in the source image.

MicroRNAs (miRNAs) play pivotal roles in gene expression regulation by binding to target sites of messenger RNAs (mRNAs). While identifying functional targets of miRNAs is of utmost importance, their prediction remains a great challenge. Previous computational algorithms have major limitations. They use conservative candidate target site (CTS) selection criteria mainly focusing on canonical site types, rely on laborious and time-consuming manual feature extraction, and do not fully capitalize on the information underlying miRNA-CTS interactions. In this paper, we introduce TargetNet, a novel deep learning-based algorithm for functional miRNA target prediction. To address the limitations of previous approaches, TargetNet has three key components: (1) relaxed CTS selection criteria accommodating irregularities in the seed region, (2) a novel miRNA-CTS sequence encoding scheme incorporating extended seed region alignments, and (3) a deep residual network-based prediction model. The proposed model was trained with miRNA-CTS pair datasets and evaluated with miRNA-mRNA pair datasets. TargetNet advances the previous state-of-the-art algorithms used in functional miRNA target classification. Furthermore, it demonstrates great potential for distinguishing high-functional miRNA targets.

In this work, we propose a novel meta-learning approach for few-shot classification, which learns transferable prior knowledge across tasks and directly produces network parameters for similar unseen tasks with training samples. Our approach, called LGM-Net, includes two key modules, namely, TargetNet and MetaNet. The TargetNet module is a neural network for solving a specific task and the MetaNet module aims at learning to generate functional weights for TargetNet by observing training samples. We also present an intertask normalization strategy for the training process to leverage common information shared across different tasks. The experimental results on Omniglot and miniImageNet datasets demonstrate that LGM-Net can effectively adapt to similar unseen tasks and achieve competitive performance, and the results on synthetic datasets show that transferable prior knowledge is learned by the MetaNet module via mapping training data to functional weights. LGM-Net enables fast learning and adaptation since no further tuning steps are required compared to other meta-learning approaches.