Rich Electronic Health Records (EHR), have created opportunities to improve clinical processes using machine learning methods. Prediction of the same patient events at different time horizons can have very different applications and interpretations; however, limited number of events in each potential time window hurts the effectiveness of conventional machine learning algorithms. We propose a novel time associated meta learning (TAML) method to make effective predictions at multiple future time points. We view time-associated disease prediction as classification tasks at multiple time points. Such closely-related classification tasks are an excellent candidate for model-based meta learning. To address the sparsity problem after task splitting, TAML employs a temporal information sharing strategy to augment the number of positive samples and include the prediction of related phenotypes or events in the meta-training phase. We demonstrate the effectiveness of TAML on multiple clinical datasets, where it consistently outperforms a range of strong baselines. We also develop a MetaEHR package for implementing both time-associated and time-independent few-shot prediction on EHR data.

Meta-learning approaches have been proposed to tackle the few-shot learning problem.Typically, a meta-learner is trained on a variety of tasks in the hopes of being generalizable to new tasks. However, the generalizability on new tasks of a meta-learner could be fragile when it is over-trained on existing tasks during meta-training phase. In other words, the initial model of a meta-learner could be too biased towards existing tasks to adapt to new tasks, especially when only very few examples are available to update the model. To avoid a biased meta-learner and improve its generalizability, we propose a novel paradigm of Task-Agnostic Meta-Learning (TAML) algorithms. Specifically, we present an entropy-based approach that meta-learns an unbiased initial model with the largest uncertainty over the output labels by preventing it from over-performing in classification tasks. Alternatively, a more general inequality-minimization TAML is presented for more ubiquitous scenarios by directly minimizing the inequality of initial losses beyond the classification tasks wherever a suitable loss can be defined.Experiments on benchmarked datasets demonstrate that the proposed approaches outperform compared meta-learning algorithms in both few-shot classification and reinforcement learning tasks.