Background and Objective: Differentiating wide complex tachycardia (WCT) is clinically critical yet challenging due to morphological similarities in electrocardiogram (ECG) signals between life-threatening ventricular tachycardia (VT) and supraventricular tachycardia with aberrancy (SVT-A). Misdiagnosis carries fatal risks. We propose a computationally efficient deep learning solution to improve diagnostic accuracy and provide model interpretability for clinical deployment. Methods: A novel lightweight parallel deep architecture is introduced. Each pipeline processes individual ECG leads using two 1D-CNN blocks to extract local features. Feature maps are concatenated across leads, followed by LSTM layers to capture temporal dependencies. Final classification employs fully connected layers. Explainability is achieved via Shapley Additive Explanations (SHAP) for local/global interpretation. The model was evaluated on a 35-subject ECG database using standard performance metrics. Results: The model achieved $95.63\%$ accuracy ($95\%$ CI: $93.07-98.19\%$), with sensitivity=$95.10\%$, specificity=$96.06\%$, and F1-score=$95.12\%$. It outperformed state-of-the-art methods in both accuracy and computational efficiency, requiring minimal CNN blocks per pipeline. SHAP analysis demonstrated clinically interpretable feature contributions. Conclusions: Our end-to-end framework delivers high-precision WCT classification with minimal computational overhead. The integration of SHAP enhances clinical trust by elucidating decision logic, supporting rapid, informed diagnosis. This approach shows significant promise for real-world ECG analysis tools.

--Despite their staggering capabilities as assistant tools, often exceeding human performances, Large Language Models (LLMs) are still prone to jailbreak attempts from malevolent users. Although red teaming practices have already identified and helped to address several such jailbreak techniques, one particular sturdy approach involving role-playing (which we named'Goofy Game') seems effective against most of the current LLMs safeguards. This can result in the provision of unsafe content, which, although not harmful per se, might lead to dangerous consequences if delivered in a setting such as the medical domain. In this preliminary and exploratory study, we provide an initial analysis of how, even without technical knowledge of the internal architecture and parameters of generative AI models, a malicious user could construct a role-playing prompt capable of coercing an LLM into producing incorrect (and potentially harmful) clinical suggestions. We aim to illustrate a specific vulnerability scenario, providing insights that can support future advancements in the field. Warning: this paper contains examples with unsafe content.

To drive health innovation that meets the needs of all and democratize healthcare, there is a need to assess the generalization performance of deep learning (DL) algorithms across various distribution shifts to ensure that these algorithms are robust. This retrospective study is, to the best of our knowledge, the first to develop and assess the generalization performance of a deep learning (DL) model for AF events detection from long term beat-to-beat intervals across ethnicities, ages and sexes. The new recurrent DL model, denoted ArNet2, was developed on a large retrospective dataset of 2,147 patients totaling 51,386 hours of continuous electrocardiogram (ECG). The models generalization was evaluated on manually annotated test sets from four centers (USA, Israel, Japan and China) totaling 402 patients. The model was further validated on a retrospective dataset of 1,730 consecutives Holter recordings from the Rambam Hospital Holter clinic, Haifa, Israel. The model outperformed benchmark state-of-the-art models and generalized well across ethnicities, ages and sexes. Performance was higher for female than male and young adults (less than 60 years old) and showed some differences across ethnicities. The main finding explaining these variations was an impairment in performance in groups with a higher prevalence of atrial flutter (AFL). Our findings on the relative performance of ArNet2 across groups may have clinical implications on the choice of the preferred AF examination method to use relative to the group of interest.

We develop a multi-task convolutional neural network (CNN) to classify multiple diagnoses from 12-lead electrocardiograms (ECGs) using a dataset comprised of over 40,000 ECGs, with labels derived from cardiologist clinical interpretations. Since many clinically important classes can occur in low frequencies, approaches are needed to improve performance on rare classes. We compare the performance of several single-class classifiers on rare classes to a multi-headed classifier across all available classes. We demonstrate that the addition of common classes can significantly improve CNN performance on rarer classes when compared to a model trained on the rarer class in isolation. Using this method, we develop a model with high performance as measured by F1 score on multiple clinically relevant classes compared against the gold-standard cardiologist interpretation.

This study targets to automatically annotate on arrhythmia by deep network. The investigated types include sinus rhythm, asystole (Asys), supraventricular tachycardia (Tachy), ventricular flutter or fibrillation (VF/VFL), ventricular tachycardia (VT). Methods: 13s limb lead ECG chunks from MIT malignant ventricular arrhythmia database (VFDB) and MIT normal sinus rhythm database were partitioned into subsets for 5-fold cross validation. These signals were resampled to 200Hz, filtered to remove baseline wandering, projected to 2D gray spectrum and then fed into a deep network with brand-new structure. In this network, a feature vector for a single time point was retrieved by residual layers, from which latent representation was extracted by variational autoencoder (VAE). These front portions were trained to meet a certain threshold in loss function, then fixed while training procedure switched to remaining bidirectional recurrent neural network (RNN), the very portions to predict an arrhythmia category. Attention windows were polynomial lumped on RNN outputs for learning from details to outlines. And over sampling was employed for imbalanced data. The trained model was wrapped into docker image for deployment in edge or cloud. Conclusion: Promising sensitivities were achieved in four arrhythmias and good precision rates in two ventricular arrhythmias were also observed. Moreover, it was proven that latent representation by VAE, can significantly boost the speed of convergence and accuracy.

These devices are implanted and perform three types of actions: l.monitor the heart 2.to pace the heart 3.to apply high energy/high voltage electric shock 1bey sense the electrical activity of the heart through leads attached to the heart tissue. Two types of sensing are commooly used: Single Chamber: Lead attached to the Right Ventricular Apex (RVA) Dual Chamber: An additional lead is attached to the High Right Atrium (HRA). The actions performed by defibrillators are based on the outcome of a classification procedure based on the heart rhythms of different heart diseases (abnormal rhythms or "arrhythmias").

These devices are implanted and perform three types of actions: l.monitor the heart 2.to pace the heart 3.to apply high energy/high voltage electric shock 1bey sense the electrical activity of the heart through leads attached to the heart tissue. Two types of sensing are commooly used: Single Chamber: Lead attached to the Right Ventricular Apex (RVA) Dual Chamber: An additional lead is attached to the High Right Atrium (HRA). The actions performed by defibrillators are based on the outcome of a classification procedure based on the heart rhythms of different heart diseases (abnormal rhythms or "arrhythmias").

Thesedevices are implanted and perform three types of actions: l.monitor the heart 2.to pace the heart 3.to apply high energy/high voltage electric shock 1bey sense the electrical activity of the heart through leads attached to the heart tissue. Two types of sensing are commooly used: Single Chamber: Lead attached to the Right Ventricular Apex (RVA) Dual Chamber: An additional lead is attached to the High Right Atrium (HRA). The actions performed by defibrillators are based on the outcome of a classification procedure based on the heart rhythms of different heart diseases (abnormal rhythms or "arrhythmias").