Identifying and understanding the co-occurrence of multiple long-term conditions (MLTC) in individuals with intellectual disabilities (ID) is vital for effective healthcare management. These individuals often face earlier onset and higher prevalence of MLTCs, yet specific co-occurrence patterns remain unexplored. This study applies an unsupervised approach to characterise MLTC clusters based on shared disease trajectories using electronic health records (EHRs) from 13069 individuals with ID in Wales (2000-2021). Disease associations and temporal directionality were assessed, followed by spectral clustering to group shared trajectories. The population consisted of 52.3% males and 47.7% females, with an average of 4.5 conditions per patient. Males under 45 formed a single cluster dominated by neurological conditions (32.4%), while males above 45 had three clusters, the largest characterised circulatory (51.8%). Females under 45 formed one cluster with digestive conditions (24.6%) as most prevalent, while those aged 45 and older showed two clusters: one dominated by circulatory (34.1%), and the other by digestive (25.9%) and musculoskeletal (21.9%) system conditions. Mental illness, epilepsy, and reflux were common across groups. These clusters offer insights into disease progression in individuals with ID, informing targeted interventions and personalised healthcare strategies.

Interdisciplinary studies often require researchers to explore literature in diverse branches of knowledge. Yet, navigating through the highly scattered knowledge from unfamiliar disciplines poses a significant challenge. In this paper, we introduce DiscipLink, a novel interactive system that facilitates collaboration between researchers and large language models (LLMs) in interdisciplinary information seeking (IIS). Based on users' topics of interest, DiscipLink initiates exploratory questions from the perspectives of possible relevant fields of study, and users can further tailor these questions. DiscipLink then supports users in searching and screening papers under selected questions by automatically expanding queries with disciplinary-specific terminologies, extracting themes from retrieved papers, and highlighting the connections between papers and questions. Our evaluation, comprising a within-subject comparative experiment and an open-ended exploratory study, reveals that DiscipLink can effectively support researchers in breaking down disciplinary boundaries and integrating scattered knowledge in diverse fields. The findings underscore the potential of LLM-powered tools in fostering information-seeking practices and bolstering interdisciplinary research.

Numerical models of electromyographic (EMG) signals have provided a huge contribution to our fundamental understanding of human neurophysiology and remain a central pillar of motor neuroscience and the development of human-machine interfaces. However, whilst modern biophysical simulations based on finite element methods are highly accurate, they are extremely computationally expensive and thus are generally limited to modelling static systems such as isometrically contracting limbs. As a solution to this problem, we propose a transfer learning approach, in which a conditional generative model is trained to mimic the output of an advanced numerical model. To this end, we present BioMime, a conditional generative neural network trained adversarially to generate motor unit activation potential waveforms under a wide variety of volume conductor parameters. We demonstrate the ability of such a model to predictively interpolate between a much smaller number of numerical model's outputs with a high accuracy. Consequently, the computational load is dramatically reduced, which allows the rapid simulation of EMG signals during truly dynamic and naturalistic movements.

The recent increase in the availability of system condition monitoring data has lead to increases in the use of data-driven approaches for fault diagnostics. The accuracy of the fault detection and classification using these approaches is generally good when abundant labelled data on healthy and faulty system conditions exists and the diagnosis problem is formulated as a supervised learning task, i.e. supervised fault diagnosis. It is, however, relatively common in real situations that only a small fraction of the system condition monitoring data are labeled as healthy and the rest is unlabeled due to the uncertainty of the number and type of faults that may occur. In this case, supervised fault diagnosis performs poorly. Fault diagnosis with an unknown number and nature of faults is an open set learning problem where the knowledge of the faulty system is incomplete during training and the number and extent of the faults, of different types, can evolve during testing. In this paper, we propose to formulate the open set diagnostics problem as a semi-supervised learning problem and we demonstrate how it can be solved using a knowledge-induced learning approach with adaptive sampling variational autoencoders (KIL-AdaVAE) in combination with a one-class classifier. The fault detection and segmentation capability of the proposed method is demonstrated on a simulated case study using the Advanced Geared Turbofan 30000 (AGTF30) dynamical model under real flight conditions and induced faults of 17 fault types. The performance of the method is compared to the different learning strategies (supervised learning, supervised learning with embedding and semi-supervised learning) and deep learning algorithms. The results demonstrate that the proposed method is able to significantly outperform all other tested methods in terms of fault detection and fault segmentation.