Over the last several decades, computational neuroscience researchers have proposed a variety of "biologically plausible" models of synaptic plasticity that seek to provide normative accounts of a variety of learning processes in the brain--these models aim to explain how modifications of

Humans and other animals are capable of improving their learning performance as they solve related tasks from a given problem domain, to the point of being able to learn from extremely limited data. While synaptic plasticity is generically thought to underlie learning in the brain, the precise neural and synaptic mechanisms by which learning processes improve through experience are not well understood. Here, we present a general-purpose, biologically-plausible meta-learning rule which estimates gradients with respect to the parameters of an underlying learning algorithm by simply running it twice. Our rule may be understood as a generalization of contrastive Hebbian learning to meta-learning and notably, it neither requires computing second derivatives nor going backwards in time, two characteristic features of previous gradient-based methods that are hard to conceive in physical neural circuits. We demonstrate the generality of our rule by applying it to two distinct models: a complex synapse with internal states which consolidate task-shared information, and a dual-system architecture in which a primary network is rapidly modulated by another one to learn the specifics of each task. For both models, our meta-learning rule matches or outperforms reference algorithms on a wide range of benchmark problems, while only using information presumed to be locally available at neurons and synapses. We corroborate these findings with a theoretical analysis of the gradient estimation error incurred by our rule.

Attractor networks require neuronal connections to be highly structured in order to maintain attractor states that represent information, while excitation and inhibition balanced networks (E-INNs) require neuronal connections to be random and sparse to generate irregular neuronal firings. Despite being regarded as canonical models of neural circuits, both types of networks are usually studied in isolation, and it remains unclear how they coexist in the brain, given their very different structural demands. In this study, we investigate the compatibility of continuous attractor neural networks (CANNs) and E-INNs. In line with recent experimental data, we find that a neural circuit can exhibit both the traits of CANNs and E-INNs if the neuronal synapses consist of two sets: one set is strong and fast for irregular firing, and the other set is weak and slow for attractor dynamics. Our results from simulations and theoretical analysis reveal that the network also exhibits enhanced performance compared to the case of using only one set of synapses, with accelerated convergence of attractor states and retained E-I balanced condition for localized input. We also apply the network model to solve a real-world tracking problem and demonstrate that it can track fast-moving objects well. We hope that this study provides insight into how structured neural computations are realized by irregular firings of neurons.

Many networks in the brain are sparsely connected, and the brain eliminates synapses during development and learning. How could the brain decide which synapses to prune? In a recurrent network, determining the importance of a synapse between two neurons is a difficult computational problem, depending on the role that both neurons play and on all possible pathways of information flow between them. Noise is ubiquitous in neural systems, and often considered an irritant to be overcome. Here we suggest that noise could play a functional role in synaptic pruning, allowing the brain to probe network structure and determine which synapses are redundant. We construct a simple, local, unsupervised plasticity rule that either strengthens or prunes synapses using only synaptic weight and the noise-driven covariance of the neighboring neurons. For a subset of linear and rectified-linear networks, we prove that this rule preserves the spectrum of the original matrix and hence preserves network dynamics even when the fraction of pruned synapses asymptotically approaches 1. The plasticity rule is biologically-plausible and may suggest a new role for noise in neural computation.

Weight quantization in spiking neural networks (SNNs) could further reduce energy consumption. However, quantizing weights without sacrificing accuracy remains challenging. In this study, inspired by astrocyte-mediated synaptic modulation in the biological nervous systems, we propose Temporal-adaptive Weight Quantization (TaWQ), which incorporates weight quantization with temporal dynamics to adaptively allocate ultra-low-bit weights along the temporal dimension. Extensive experiments on static (e.g., ImageNet) and neuromorphic (e.g., CIFAR10-DVS) datasets demonstrate that our TaWQ maintains high energy efficiency (4.12M, 0.63mJ) while incurring a negligible quantization loss of only 0.22% on ImageNet.

Recent progress in diffusion-based generative models has enabled high-quality image synthesis conditioned on diverse modalities. Extending such models to brain signals could deepen our understanding of human perception and mental representations. However,electroencephalography (EEG) presents major challenges for image generation due to high noise, low spatial resolution, and strong inter-subject variability. Existing approaches,such as DreamDiffusion, BrainVis, and GWIT, primarily adapt EEG features to pre-trained Stable Diffusion models using complex alignment or classification pipelines, often resulting in large parameter counts and limited interpretability. We introduce SYNAPSE, a two-stage framework that bridges EEG signal representation learning and high-fidelity image synthesis. In Stage1, a CLIP-aligned EEG autoencoder learns a semantically structured latent representation by combining signal reconstruction and cross-modal alignment objectives. In Stage2, the pretrained encoder is frozen and integrated with a lightweight adaptation of Stable Diffusion, enabling efficient conditioning on EEG features with minimal trainable parameters. Our method achieves a semantically coherent latent space and state-of-the-art perceptual fidelity on the CVPR40 dataset, outperforming prior EEG-to-image models in both reconstruction efficiency and image quality. Quantitative and qualitative analyses demonstrate that SYNAPSE generalizes effectively across subjects, preserving visual semantics even when class-level agreement is reduced. These results suggest that reconstructing what the brain perceives, rather than what it classifies, is key to faithful EEG-based image generation.

However, even if a plant has negligible transmission delays, it may still have sizable inertial latencies. For example, if we apply a force to a visco-elastic plant, its peak velocity will be achieved after a certain delay; i.e. the velocity itself will lag the force.

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Multiplicative stochasticity such as Dropout improves the robustness and gener-alizability of deep neural networks.

In a typical deep-learning network, some signals flow along a forward path through multiple layers of processing units from the input layer to the output, while other signals flow back from the output layer along a feedback path . Forward-path signals perform inference (e.g. they try to infer what objects are