Despite this remarkable progress, there is a noticeable absence of datasets that combine electrocardiogram (ECG) data with question answering.

"It seems like this past week has been quite challenging for you," a disembodied voice tells me, before proceeding to ask a series of increasingly personal questions. "Have you been feeling down or depressed?" "Can you describe what this feeling has been like for you?" "Does the feeling lift at all when something good happens?" When I respond to each one, my chatbot interviewer thanks me for my honesty and empathises with any issues. By the end of the conversation, I will have also spoken about my sleep patterns, sex drive and appetite for food.

Ghislaine Maxwell's ultimate humiliation: Epstein's sex trafficker girlfriend poses in outrageous outfits and exposes herself in dozens of photos released from the billionaire paedophile's files Silent Trump flees growing storm over Epstein'cover-up' as he jets off for holidays without ANY comment How you can ease the agony of carpal tunnel syndrome. The'change of pace' sex move that sends ANY woman wild. Here's the precise moment to deploy it and what to do with your eyes. Corey Feldman walks back claim that Corey Haim'molested' him after late star's mother slammed his comments Emily in Paris cast left'aghast' and'walking on eggshells' as off-camera drama becomes overwhelming... and whispers swirl about a CURSE Truth about THIS photo of Karoline Leavitt's face... and why if she was non-binary and disabled, Vanity Fair would never have done this: KENNEDY After 27 years as a TV anchor I was suddenly pulled off screens. My boss's explanation was a brutal lesson in loyalty I was dead for 105 minutes and learned exactly how you get into heaven... then Jesus spoke six words into my mind and sent me back Jake Paul's jaw is broken in Anthony Joshua battering: YouTuber-turned-boxer rushes to hospital I was falsely accused of being the Brown University shooter... America's great divide laid bare as Wall Street splurges record bonuses on outrageously lavish homes while the rest of the country struggles Andrew's fury at anyone who doesn't bow and scrape.

The PRO-CTCAE is an NCI-developed patient-reported outcome system for capturing symptomatic adverse events in oncology trials. It comprises a large library drawn from the CTCAE vocabulary, and item selection for a given trial is typically guided by expected toxicity profiles from prior data. Selecting too many PRO-CTCAE items can burden patients and reduce compliance, while too few may miss important safety signals. We present an automated method to select a minimal yet comprehensive PRO-CTCAE subset based on historical safety data. Each candidate PRO-CTCAE symptom term is first mapped to its corresponding MedDRA Preferred Terms (PTs), which are then encoded into Safeterm, a high-dimensional semantic space capturing clinical and contextual diversity in MedDRA terminology. We score each candidate PRO item for relevance to the historical list of adverse event PTs and combine relevance and incidence into a utility function. Spectral analysis is then applied to the combined utility and diversity matrix to identify an orthogonal set of medical concepts that balances relevance and diversity. Symptoms are rank-ordered by importance, and a cut-off is suggested based on the explained information. The tool is implemented as part of the Safeterm trial-safety app. We evaluate its performance using simulations and oncology case studies in which PRO-CTCAE was employed. This automated approach can streamline PRO-CTCAE design by leveraging MedDRA semantics and historical data, providing an objective and reproducible method to balance signal coverage against patient burden.

Research links variations in the gene GRIN2A to a higher risk of developing schizophrenia and other forms of mental illness. A team of physicians specializing in genetics and neurology discovered that mental illnesses such as schizophrenia are closely linked to mutations in the GRIN2A gene. The scientists mantain that identifying this genetic risk factor opens up the possibility of designing preventive therapies in the future. The GRIN2A gene regulates communication between neurons by producing the GluN2A protein. When functioning optimally, it promotes the transmission of electrical signals between nerve cells and facilitates essential processes such as learning, memory, language, and brain development.

Demand for mental health support through AI chatbots is surging, though current systems present several limitations, like sycophancy or overvalidation, and reinforcement of maladaptive beliefs. A core obstacle to the creation of better systems is the scarcity of benchmarks that capture the complexity of real therapeutic interactions. Most existing benchmarks either only test clinical knowledge through multiple-choice questions or assess single responses in isolation. To bridge this gap, we present MindEval, a framework designed in collaboration with Ph.D-level Licensed Clinical Psychologists for automatically evaluating language models in realistic, multi-turn mental health therapy conversations. Through patient simulation and automatic evaluation with LLMs, our framework balances resistance to gaming with reproducibility via its fully automated, model-agnostic design. We begin by quantitatively validating the realism of our simulated patients against human-generated text and by demonstrating strong correlations between automatic and human expert judgments. Then, we evaluate 12 state-of-the-art LLMs and show that all models struggle, scoring below 4 out of 6, on average, with particular weaknesses in problematic AI-specific patterns of communication. Notably, reasoning capabilities and model scale do not guarantee better performance, and systems deteriorate with longer interactions or when supporting patients with severe symptoms. We release all code, prompts, and human evaluation data.

Generative AI systems may pose serious risks to individuals vulnerable to eating disorders. Existing safeguards tend to overlook subtle but clinically significant cues, leaving many risks unaddressed. To better understand the nature of these risks, we conducted semi-structured interviews with 15 clinicians, researchers, and advocates with expertise in eating disorders. Using abductive qualitative analysis, we developed an expert-guided taxonomy of generative AI risks across seven categories: (1) providing generalized health advice; (2) encouraging disordered behaviors; (3) supporting symptom concealment; (4) creating thinspiration; (5) reinforcing negative self-beliefs; (6) promoting excessive focus on the body; and (7) perpetuating narrow views about eating disorders. Our results demonstrate how certain user interactions with generative AI systems intersect with clinical features of eating disorders in ways that may intensify risk. We discuss implications of our work, including approaches for risk assessment, safeguard design, and participatory evaluation practices with domain experts.

What happens to your body during a panic attack? 'Just breathe' is more than just a nice saying. Up to one third of people experience at least one panic attack in their lifetimes. Breakthroughs, discoveries, and DIY tips sent every weekday. It happens all at once--your heartbeat becomes a jackhammer, your body closes in on you like a corset.

The fast growth of digital health systems has led to a need to better comprehend how they interpret and represent patient-reported symptoms. Chatbots have been used in healthcare to provide clinical support and enhance the user experience, making it possible to provide meaningful clinical patterns from text-based data through chatbots. The proposed research utilises several different natural language processing methods to study the occurrences of symptom descriptions in medicine as well as analyse the patterns that emerge through these conversations within medical bots. Through the use of the Medical Conversations to Disease Dataset which contains 960 multi-turn dialogues divided into 24 Clinical Conditions, a standardised representation of conversations between patient and bot is created for further analysis by computational means. The multi-method approach uses a variety of tools, including Latent Dirichlet Allocation (LDA) to identify latent symptom themes, K-Means to group symptom descriptions by similarity, Transformer-based Named Entity Recognition (NER) to extract medical concepts, and the Apriori algorithm to discover frequent symptom pairs. Findings from the analysis indicate a coherent structure of clinically relevant topics, moderate levels of clustering cohesiveness and several high confidence rates on the relationships between symptoms like fever headache and rash itchiness. The results support the notion that conversational medical data can be a valuable diagnostic signal for early symptom interpretation, assist in strengthening decision support and improve how users interact with tele-health technology. By demonstrating a method for converting unstructured free-flowing dialogue into actionable knowledge regarding symptoms this work provides an extensible framework to further enhance future performance, dependability and clinical utility of selecting medical chatbots.