StrokeRehab, as a new action-recognition benchmark that includes elemental short-duration actions labeled at a high temporal resolution.

Action segmentation: Action segmentation is the problem of segmenting an input stream of data, labeling each frame according to the action that is being carried out. B.1 Trained only on healthy subjects B.2 Trained only healthy subjects and stroke-impaired patients Table 5: Results on StrokeRehab Healthy controls and stroke impaired patients. Table 3 in the main paper showed the results of model generalization when the raw2seq model is trained and tested on various combination of subject cohorts. The TPR is the ratio between the correctly-identified actions and the total ground-truth actions. We provide additional analysis as follows.

Photon scattering has traditionally limited the ability of near-infrared spectroscopy (NIRS) to extract accurate, layer-specific information from the brain. This limitation restricts its clinical utility for precise neurological monitoring. To address this, we introduce an AI-driven, high-density NIRS system optimized to provide real-time, layer-specific oxygenation data from the brain cortex, specifically targeting acute neuro-emergencies. Our system integrates high-density NIRS reflectance data with a neural network trained on MRI-based synthetic datasets. This approach achieves robust cortical oxygenation accuracy across diverse anatomical variations. In simulations, our AI-assisted NIRS demonstrated a strong correlation (R2=0.913) with actual cortical oxygenation, markedly outperforming conventional methods (R2=0.469). Furthermore, biomimetic phantom experiments confirmed its superior anatomical reliability (R2=0.986) compared to standard commercial devices (R2=0.823). In clinical validation with healthy subjects and ischemic stroke patients, the system distinguished between the two groups with an AUC of 0.943. This highlights its potential as an accessible, high-accuracy diagnostic tool for emergency and point-of-care settings. These results underscore the system's capability to advance neuro-monitoring precision through AI, enabling timely, data-driven decisions in critical care environments.

Rehabilitation therapy for stroke patients faces a supply shortage despite the increasing demand. To address this issue, remote monitoring systems that reduce the burden on medical staff are emerging as a viable alternative. A key component of these remote monitoring systems is Human Action Recognition (HAR) technology, which classifies actions. However, existing HAR studies have primarily focused on non-disable individuals, making them unsuitable for recognizing the actions of stroke patients. HAR research for stroke has largely concentrated on classifying relatively simple actions using machine learning rather than deep learning. In this study, we designed a system to monitor the actions of stroke patients, focusing on domiciliary upper limb Activities of Daily Living (ADL). Our system utilizes IMU (Inertial Measurement Unit) sensors and an RGB-D camera, which are the most common modalities in HAR. We directly collected a dataset through this system, investigated an appropriate preprocess and proposed a deep learning model suitable for processing multimodal data. We analyzed the collected dataset and found that the action data of stroke patients is less clustering than that of non-disabled individuals. Simultaneously, we found that the proposed model learns similar tendencies for each label in data with features that are difficult to clustering. This study suggests the possibility of expanding the deep learning model, which has learned the action features of stroke patients, to not only simple action recognition but also feedback such as assessment contributing to domiciliary rehabilitation in future research. The code presented in this study is available at https://github.com/ye-Kim/MMeViT.

Mechanical thrombectomy has become the standard of care in patients with stroke due to large vessel occlusion (LVO). However, only 50% of successfully treated patients show a favorable outcome. We developed and evaluated interpretable deep learning models to predict functional outcomes in terms of the modified Rankin Scale score alongside individualized treatment effects (ITEs) using data of 449 LVO stroke patients from a randomized clinical trial. Besides clinical variables, we considered non-contrast CT (NCCT) and angiography (CTA) scans which were integrated using novel foundation models to make use of advanced imaging information. Clinical variables had a good predictive power for binary functional outcome prediction (AUC of 0.719 [0.666, 0.774]) which could slightly be improved when adding CTA imaging (AUC of 0.737 [0.687, 0.795]). Adding NCCT scans or a combination of NCCT and CTA scans to clinical features yielded no improvement. The most important clinical predictor for functional outcome was pre-stroke disability. While estimated ITEs were well calibrated to the average treatment effect, discriminatory ability was limited indicated by a C-for-Benefit statistic of around 0.55 in all models. In summary, the models allowed us to jointly integrate CT imaging and clinical features while achieving state-of-the-art prediction performance and ITE estimates. Yet, further research is needed to particularly improve ITE estimation.

Gait asymmetry is a significant clinical characteristic of hemiplegic gait that most stroke survivors suffer, leading to limited mobility and long-term negative impacts on their quality of life. Although a variety of exoskeleton controls have been developed for robot-assisted gait rehabilitation, little attention has been paid to correcting the gait asymmetry of stroke patients following the assist-as-need (AAN) principle, and it is still challenging to properly share control between the exoskeleton and stroke patients with partial motor control. In view of this, this article proposes an AAN hip exoskeleton control with human-in-the-loop optimization to correct gait asymmetry in stroke patients. To realize the AAN concept, an objective function was designed for real-time evaluation of the subject's gait performance and active participation, which considers the variability of natural human movement and guides the online tuning of control parameters on a subject-specific basis. In this way, patients were stimulated to contribute as much as possible to movement, thus maximizing the efficiency and outcomes of post-stroke gait rehabilitation. Finally, an experimental study was conducted to verify the feasibility and effectiveness of the proposed AAN control on healthy subjects with artificial gait impairment. For the first time, the common hypothesis that AAN controls can improve human active participation was validated from the biomechanics viewpoint.

Explainability remains a significant problem for AI models in medical imaging, making it challenging for clinicians to trust AI-driven predictions. We introduce 3D ReX, the first causality-based post-hoc explainability tool for 3D models. 3D ReX uses the theory of actual causality to generate responsibility maps which highlight the regions most crucial to the model's decision. We test 3D ReX on a stroke detection model, providing insight into the spatial distribution of features relevant to stroke.

Wearable silent speech systems hold significant potential for restoring communication in patients with speech impairments. However, seamless, coherent speech remains elusive, and clinical efficacy is still unproven. Here, we present an AI-driven intelligent throat (IT) system that integrates throat muscle vibrations and carotid pulse signal sensors with large language model (LLM) processing to enable fluent, emotionally expressive communication. The system utilizes ultrasensitive textile strain sensors to capture high-quality signals from the neck area and supports token-level processing for real-time, continuous speech decoding, enabling seamless, delay-free communication. In tests with five stroke patients with dysarthria, IT's LLM agents intelligently corrected token errors and enriched sentence-level emotional and logical coherence, achieving low error rates (4.2% word error rate, 2.9% sentence error rate) and a 55% increase in user satisfaction. This work establishes a portable, intuitive communication platform for patients with dysarthria with the potential to be applied broadly across different neurological conditions and in multi-language support systems. This impairment drastically restricts effective communication, lowers quality of life, substantially impedes the rehabilitation process, and can even lead to severe psychological issues [1, 2, 3, 4]. Augmentative and alternative communication (AAC) technologies have been developed to address these challenges, including letter-by-letter spelling systems utilizing head or eye tracking [5, 6, 7, 8] and neuroprosthetics powered by brain-computer interface (BCI) devices [9, 10, 11, 12].