Environment Animals Wildlife Whales Hawaii's short-finned pilot whales eat over 77,000 squid a year Breakthroughs, discoveries, and DIY tips sent every weekday. The black marine mammals with bulbous heads primarily feed on the cephalopods and some small amounts of fish. But just how much squid do they eat? New estimates suggest that individual Hawaiian short-finned pilot whales eat between 82 and 202 squid per day. The findings are detailed in a study published today in the and could help local conservation efforts.

Breakthroughs, discoveries, and DIY tips sent every weekday. Oceanographers on an excursion in the Southern Ocean captured a chance, unprecedented encounter with a sizable deep-sea squid. While piloting a remotely operated submersible 7,000 feet below the ocean surface from aboard the Schmidt Ocean Institute's research vessel Falkor (too), experts glimpsed a three-foot-long Gonatus antarcticus specimen. But according to National Geographic's announcement, the team wasn't even supposed to be in that location when they stumbled across the elusive cephalopod. "The ice blocks were moving so fast, it would put all the ships in danger, so we had to rearrange everything," said Manuel Novillo, a researcher at the Instituto de Diversidad y Ecología Animal.

Relational databases are central to modern data management, yet most data exists in unstructured forms like text documents. To bridge this gap, we leverage large language models (LLMs) to automatically synthesize a relational database by generating its schema and populating its tables from raw text. We introduce SQUiD, a novel neurosymbolic framework that decomposes this task into four stages, each with specialized techniques. Our experiments show that SQUiD consistently outperforms baselines across diverse datasets.

Drug development is a critical but notoriously resource- and time-consuming process. In this manuscript, we develop a novel generative artificial intelligence (genAI) method DiffSMol to facilitate drug development. DiffSmol generates 3D binding molecules based on the shapes of known ligands. DiffSMol encapsulates geometric details of ligand shapes within pre-trained, expressive shape embeddings and then generates new binding molecules through a diffusion model. DiffSMol further modifies the generated 3D structures iteratively via shape guidance to better resemble the ligand shapes. It also tailors the generated molecules toward optimal binding affinities under the guidance of protein pockets. Here, we show that DiffSMol outperforms the state-of-the-art methods on benchmark datasets. When generating binding molecules resembling ligand shapes, DiffSMol with shape guidance achieves a success rate 61.4%, substantially outperforming the best baseline (11.2%), meanwhile producing molecules with novel molecular graph structures. DiffSMol with pocket guidance also outperforms the best baseline in binding affinities by 13.2%, and even by 17.7% when combined with shape guidance. Case studies for two critical drug targets demonstrate very favorable physicochemical and pharmacokinetic properties of the generated molecules, thus, the potential of DiffSMol in developing promising drug candidates.

Ligand-based drug design aims to identify novel drug candidates of similar shapes with known active molecules. In this paper, we formulated an in silico shape-conditioned molecule generation problem to generate 3D molecule structures conditioned on the shape of a given molecule. To address this problem, we developed a translation-and rotation-equivariant shape-guided generative model ShapeMol . ShapeMol consists of an equivariant shape encoder that maps molecular surface shapes into latent embeddings, and an equivariant diffusion model that generates 3D molecules based on these embeddings. Experimental results show that ShapeMol can generate novel, diverse, drug-like molecules that retain 3D molecular shapes similar to the given shape condition. These results demonstrate the potential of ShapeMol in designing drug candidates of desired 3D shapes binding to protein target pockets.

Much of text-to-speech research relies on human evaluation, which incurs heavy costs and slows down the development process. The problem is particularly acute in heavily multilingual applications, where recruiting and polling judges can take weeks. We introduce SQuId (Speech Quality Identification), a multilingual naturalness prediction model trained on over a million ratings and tested in 65 locales-the largest effort of this type to date. The main insight is that training one model on many locales consistently outperforms mono-locale baselines. We present our task, the model, and show that it outperforms a competitive baseline based on w2v-BERT and VoiceMOS by 50.0%. We then demonstrate the effectiveness of cross-locale transfer during fine-tuning and highlight its effect on zero-shot locales, i.e., locales for which there is no fine-tuning data. Through a series of analyses, we highlight the role of non-linguistic effects such as sound artifacts in cross-locale transfer. Finally, we present the effect of our design decision, e.g., model size, pre-training diversity, and language rebalancing with several ablation experiments.

Shape-based virtual screening is widely employed in ligand-based drug design to search chemical libraries for molecules with similar 3D shapes yet novel 2D chemical structures compared to known ligands. 3D deep generative models have the potential to automate this exploration of shape-conditioned 3D chemical space; however, no existing models can reliably generate valid drug-like molecules in conformations that adopt a specific shape such as a known binding pose. We introduce a new multimodal 3D generative model that enables shape-conditioned 3D molecular design by equivariantly encoding molecular shape and variationally encoding chemical identity. We ensure local geometric and chemical validity of generated molecules by using autoregressive fragment-based generation with heuristic bonding geometries, allowing the model to prioritize the scoring of rotatable bonds to best align the growing conformational structure to the target shape. We evaluate our 3D generative model in tasks relevant to drug design including shape-conditioned generation of chemically diverse molecular structures and shape-constrained molecular property optimization, demonstrating its utility over virtual screening of enumerated libraries.

A rare giant squid was discovered dead on a beach in Cape Town, South Africa, months after another washed up six miles away. Twitter user Tim Dee, who found the strange-looking sea creature on Scarborough Beach on Tuesday, shared photos and videos online that show the colorful squid's gigantic eye. 'Giant squid species wrecked on Scarborough beach this morning,' he wrote. Twitter user Tim Dee, who found the strange-looking sea creature (above) on Scarborough Beach on Tuesday, shared photos and videos online that show the colorful squid's gigantic eye Dee's video shows a marine biologist pulling back flesh to reveal the squid's huge beak that it uses for hunting and fishing. The sea creature, which looks like something Salvador Dali would have painted, is also known for having a very large eye - usually up to 11 inches in diameter with a 3.5 inch pupil.

CES might look a little different this year, but that hasn't stopped Lenovo from doing what it does best: using the industry to event to launch many, many new products. In addition to the usual laptops, the company is showing off a new smart clock, the Smart Clock Essential with Alexa. Aside from a minimalist cloth design that clearly borrows from last year's Smart Clock 2, the new Essential improves on the old by adding a pogo docking pin at the bottom and, well, support for Amazon Alexa. The original Essential clock only worked with Google Assistant, and while I was hoping this new device could handle both, the new Essential with Alexa truly is Alexa-only, while the original remains available as a Google smart clock. As an object that's meant to sit on your bedside table, there really isn't much to the new Essential. The fabric comes in either a muted "Clay Red" or pale "Misty Blue," with the entire front face given over to the 4-inch LED display.

OceanX, a team of marine biologists, media and filmmakers, embarked on a quest in 2020 to explore the depths of the Red Sea where they not only found a giant shipwreck, but a massive creature that appeared to be larger than a human. While investigating the'Pella,' which sank in November 2011, at a depth of 2,800 feet, the group spotted what they thought could be'The Giant Squid.' 'I will never forget what happened next for as long as I live,' said OceanX science program lead Mattie Rodrigue in a video taken of the discovery. 'All of a sudden, as we're looking at the bow of the shipwreck, this massive creature comes into view, takes a look at the ROV [remotely operated vehicle] and curls its entire body around the bow of the wreck.' It was not until September 2021 did the team learn that the mysterious creature was'the giant form' of the purpleback flying squid, which typically grow up to two feet long. The OceanX team traveled to the Red Sea aboard the OceanXplorer, a research vessel with a 40-ton crane to launch submersibles, towed sonar arrays and other heavy equipment down into the depths.