Inner-product operators, often referred to as kernels in statistical learning, de- fine a mapping from some input space into a feature space. The focus of this paper is the construction of biologically-motivated kernels for cortical ac- tivities. The kernels we derive, termed Spikernels, map spike count sequences into an abstract vector space in which we can perform various prediction tasks. We discuss in detail the derivation of Spikernels and describe an efficient al- gorithm for computing their value on any two sequences of neural population spike counts. We demonstrate the merits of our modeling approach using the Spikernel and various standard kernels for the task of predicting hand move- ment velocities from cortical recordings.

We devise and experiment with a dynamical kernel-based system for tracking hand movements from neural activity. The state of the system corresponds to the hand location, velocity, and acceleration, while the system's input are the instantaneous spike rates. The system's state dynamics is defined as a combination of a linear mapping from the previous estimated state and a kernel-based mapping tailored for modeling neural activities. In contrast to generative models, the activity-to-state mapping is learned using discriminative methods by minimizing a noise-robust loss function. We use this approach to predict hand trajectories on the basis of neural activity in motor cortex of behaving monkeys and find that the proposed approach is more accurate than both a static approach based on support vector regression and the Kalman filter.

We devise and experiment with a dynamical kernel-based system for tracking hand movements from neural activity. The state of the system corresponds to the hand location, velocity, and acceleration, while the system's input are the instantaneous spike rates. The system's state dynamics is defined as a combination of a linear mapping from the previous estimated state and a kernel-based mapping tailored for modeling neural activities. In contrast to generative models, the activity-to-state mapping is learned using discriminative methods by minimizing a noise-robust loss function. We use this approach to predict hand trajectories on the basis of neural activity in motor cortex of behaving monkeys and find that the proposed approach is more accurate than both a static approach based on support vector regression and the Kalman filter.

We devise and experiment with a dynamical kernel-based system for tracking hand movements from neural activity. The state of the system corresponds to the hand location, velocity, and acceleration, while the system's input are the instantaneous spike rates. The system's state dynamics isdefined as a combination of a linear mapping from the previous estimated state and a kernel-based mapping tailored for modeling neural activities. In contrast to generative models, the activity-to-state mapping is learned using discriminative methods by minimizing a noise-robust loss function. We use this approach to predict hand trajectories on the basis of neural activity in motor cortex of behaving monkeys and find that the proposed approach is more accurate than both a static approach based on support vector regression and the Kalman filter.

Inner-product operators, often referred to as kernels in statistical learning, define a mapping from some input space into a feature space. The focus of this paper is the construction of biologically-motivated kernels for cortical activities. The kernels we derive, termed Spikernels, map spike count sequences into an abstract vector space in which we can perform various prediction tasks. We discuss in detail the derivation of Spikernels and describe an efficient algorithm for computing their value on any two sequences of neural population spike counts. We demonstrate the merits of our modeling approach using the Spikernel and various standard kernels for the task of predicting hand movement velocities from cortical recordings. In all of our experiments all the kernels we tested outperform the standard scalar product used in regression with the Spikernel consistently achieving the best performance.

Inner-product operators, often referred to as kernels in statistical learning, define a mapping from some input space into a feature space. The focus of this paper is the construction of biologically-motivated kernels for cortical activities. The kernels we derive, termed Spikernels, map spike count sequences into an abstract vector space in which we can perform various prediction tasks. We discuss in detail the derivation of Spikernels and describe an efficient algorithm for computing their value on any two sequences of neural population spike counts. We demonstrate the merits of our modeling approach using the Spikernel and various standard kernels for the task of predicting hand movement velocities from cortical recordings. In all of our experiments all the kernels we tested outperform the standard scalar product used in regression with the Spikernel consistently achieving the best performance.

Inner-product operators, often referred to as kernels in statistical learning, define amapping from some input space into a feature space. The focus of this paper is the construction of biologically-motivated kernels for cortical activities. Thekernels we derive, termed Spikernels, map spike count sequences into an abstract vector space in which we can perform various prediction tasks. We discuss in detail the derivation of Spikernels and describe an efficient algorithm forcomputing their value on any two sequences of neural population spike counts. We demonstrate the merits of our modeling approach using the Spikernel and various standard kernels for the task of predicting hand movement velocitiesfrom cortical recordings. In all of our experiments all the kernels we tested outperform the standard scalar product used in regression with the Spikernel consistently achieving the best performance.