We apply a variety of machine learning methods to the study of Seiberg duality within 4d $\mathcal{N}=1$ quantum field theories arising on the worldvolumes of D3-branes probing toric Calabi-Yau 3-folds. Such theories admit an elegant description in terms of bipartite tessellations of the torus known as brane tilings or dimer models. An intricate network of infrared dualities interconnects the space of such theories and partitions it into universality classes, the prediction and classification of which is a problem that naturally lends itself to a machine learning investigation. In this paper, we address a preliminary set of such enquiries. We begin by training a fully connected neural network to identify classes of Seiberg dual theories realised on $\mathbb{Z}_m\times\mathbb{Z}_n$ orbifolds of the conifold and achieve $R^2=0.988$. Then, we evaluate various notions of robustness of our methods against perturbations of the space of theories under investigation, and discuss these results in terms of the nature of the neural network's learning. Finally, we employ a more sophisticated residual architecture to classify the toric phase space of the $Y^{6,0}$ theories, and to predict the individual gauged linear $\sigma$-model multiplicities in toric diagrams thereof. In spite of the non-trivial nature of this task, we achieve remarkably accurate results; namely, upon fixing a choice of Kasteleyn matrix representative, the regressor achieves a mean absolute error of $0.021$. We also discuss how the performance is affected by relaxing these assumptions.

We initiate the study of applications of machine learning to Seiberg duality, focusing on the case of quiver gauge theories, a problem also of interest in mathematics in the context of cluster algebras. Within the general theme of Seiberg duality, we define and explore a variety of interesting questions, broadly divided into the binary determination of whether a pair of theories picked from a series of duality classes are dual to each other, as well as the multi-class determination of the duality class to which a given theory belongs. We study how the performance of machine learning depends on several variables, including number of classes and mutation type (finite or infinite). In addition, we evaluate the relative advantages of Naive Bayes classifiers versus Convolutional Neural Networks. Finally, we also investigate how the results are affected by the inclusion of additional data, such as ranks of gauge/flavor groups and certain variables motivated by the existence of underlying Diophantine equations. In all questions considered, high accuracy and confidence can be achieved.