Diffusion models generate samples by iteratively querying learned score estimates. A rapidly growing literature focuses on accelerating sampling by minimizing the number of score evaluations, yet the information-theoretic limits of such acceleration remain unclear. In this work, we establish the first score query lower bounds for diffusion sampling. We prove that for $d$-dimensional distributions, given access to score estimates with polynomial accuracy $\varepsilon=d^{-O(1)}$ (in any $L^p$ sense), any sampling algorithm requires $\widetildeΩ(\sqrt{d})$ adaptive score queries. In particular, our proof shows that any sampler must search over $\widetildeΩ(\sqrt{d})$ distinct noise levels, providing a formal explanation for why multiscale noise schedules are necessary in practice.

We develop a diffusion-based sampler for target distributions known up to a normalising constant. To this end, we rely on the well-known diffusion path that smoothly interpolates between a (simple) base distribution and the target distribution, widely used in diffusion models. Our approach is based on a practical implementation of diffusion-annealed Langevin Monte Carlo, which approximates the diffusion path with convergence guarantees. We tackle the score estimation problem by developing an efficient sequential Monte Carlo sampler that evolves auxiliary variables from conditional distributions along the path, which provides principled score estimates for time-varying distributions. We further develop novel control variate schedules that minimise the variance of these score estimates. Finally, we provide theoretical guarantees and empirically demonstrate the effectiveness of our method on several synthetic and real-world datasets.

Score-based generative modeling (SGM) is a highly successful approach for learning a probability distribution from data and generating further samples. We prove the first polynomial convergence guarantees for the core mechanic behind SGM: drawing samples from a probability density $p$ given a score estimate (an estimate of $\nabla \ln p$) that is accurate in $L^2(p)$. Compared to previous works, we do not incur error that grows exponentially in time or that suffers from a curse of dimensionality. Our guarantee works for any smooth distribution and depends polynomially on its log-Sobolev constant. Using our guarantee, we give a theoretical analysis of score-based generative modeling, which transforms white-noise input into samples from a learned data distribution given score estimates at different noise scales. Our analysis gives theoretical grounding to the observation that an annealed procedure is required in practice to generate good samples, as our proof depends essentially on using annealing to obtain a warm start at each step. Moreover, we show that a predictor-corrector algorithm gives better convergence than using either portion alone.

Assessing published academic journal articles is a common task for evaluations of departments and individuals. Whilst it is sometimes supported by citation data, Large Language Models (LLMs) may give more useful indications of article quality. Evidence of this capability exists for two of the largest LLM families, ChatGPT and Gemini, and the medium sized LLM Gemma3 27b, but it is unclear whether smaller LLMs and reasoning models have similar abilities. This is important because larger models may be slow and impractical in some situations, and reasoning models may perform differently. Four relevant questions are addressed with Gemma3 variants, Llama4 Scout, Qwen3, Magistral Small and DeepSeek R1, on a dataset of 2,780 medical, health and life science papers in 6 fields, with two different gold standards, one novel. The results suggest that smaller (open weights) and reasoning LLMs have similar performance to ChatGPT 4o-mini and Gemini 2.0 Flash, but that 1b parameters may often, and 4b sometimes, be too few. Moreover, averaging scores from multiple identical queries seems to be a universally successful strategy, and few-shot prompts (four examples) tended to help but the evidence was equivocal. Reasoning models did not have a clear advantage. Overall, the results show, for the first time, that smaller LLMs >4b, including reasoning models, have a substantial capability to score journal articles for research quality, especially if score averaging is used.

Simulation-based inference (SBI) has become a widely used framework in applied sciences for estimating the parameters of stochastic models that best explain experimental observations. A central question in this setting is how to effectively combine multiple observations in order to improve parameter inference and obtain sharper posterior distributions. Recent advances in score-based diffusion methods address this problem by constructing a compositional score, obtained by aggregating individual posterior scores within the diffusion process. While it is natural to suspect that the accumulation of individual errors may significantly degrade sampling quality as the number of observations grows, this important theoretical issue has so far remained unexplored. In this paper, we study the compositional score produced by the GAUSS algorithm of Linhart et al. (2024) and establish an upper bound on its mean squared error in terms of both the individual score errors and the number of observations. We illustrate our theoretical findings on a Gaussian example, where all analytical expressions can be derived in a closed form.

Score-based generative modeling (SGM) is a highly successful approach for learning a probability distribution from data and generating further samples. We prove the first polynomial convergence guarantees for the core mechanic behind SGM: drawing samples from a probability density p given a score estimate (an estimate of abla \ln p) that is accurate in L 2(p) . Compared to previous works, we do not incur error that grows exponentially in time or that suffers from a curse of dimensionality. Our guarantee works for any smooth distribution and depends polynomially on its log-Sobolev constant. Using our guarantee, we give a theoretical analysis of score-based generative modeling, which transforms white-noise input into samples from a learned data distribution given score estimates at different noise scales.