With the increasing size of large language models, layer pruning has gained increased attention as a hardware-friendly approach for model compression. However, existing layer pruning methods struggle to simultaneously address key practical deployment challenges, including performance degradation, high training costs, and limited acceleration. To overcome these limitations, we propose \name, a task-\underline{E}ffective, training-\underline{E}conomical and inference-\underline{E}fficient layer pruning framework. \namespace introduces two key innovations: (1) a differentiable mask optimization method using a Gumbel-TopK sampler, enabling efficient and precise pruning mask search; and (2) an entropy-aware adaptive knowledge distillation strategy that enhances task performance. Extensive experiments over diverse model architectures and benchmarks demonstrate the superiority of our method over state-of-the-art approaches. Notably, \namespace achieves 96\% accuracy, a mere 0.8\% drop from the original model (96.8\%) on MATH-500 when pruning 25\% layers of Qwen3-32B, outperforming existing SOTA (95\%), with a 1.33$\times$ inference speedup by consuming merely 0.5B tokens (0.5\% of the post-training data volume).

Large Language Models (LLMs) have exhibited remarkable proficiency across a wide array of NLP tasks. However, the escalation in model size also engenders substantial deployment costs. While few efforts have explored model pruning techniques to reduce the size of LLMs, they mainly center on general or task-specific weights. This leads to suboptimal performance due to lacking specificity on the target domain or generality on different tasks when applied to domain-specific challenges. This work introduces an innovative unstructured dual-pruning methodology, D-Pruner, for domain-specific compression on LLM. It extracts a compressed, domain-specific, and task-agnostic LLM by identifying LLM weights that are pivotal for general capabilities, like linguistic capability and multi-task solving, and domain-specific knowledge. More specifically, we first assess general weight importance by quantifying the error incurred upon their removal with the help of an open-domain calibration dataset. Then, we utilize this general weight importance to refine the training loss, so that it preserves generality when fitting into a specific domain. Moreover, by efficiently approximating weight importance with the refined training loss on a domain-specific calibration dataset, we obtain a pruned model emphasizing generality and specificity. Our comprehensive experiments across various tasks in healthcare and legal domains show the effectiveness of D-Pruner in domain-specific compression. Our code is available at https://github.com/psunlpgroup/D-Pruner.