The skin is the largest organ in the human body, and approximately a third of the total number of cancer cases are represented by skin cancers. Melanoma is the deadliest form of skin cancer, which is responsible for an overwhelming majority of skin cancer deaths. The number of melanoma deaths is expected to increase by 4.4% in 2023. Although the mortality is significant, when detected e arly, the 5-year survival rate for melanoma is over 99% (American Cancer Society, 2022). Currently, the most accurate way to diagnose melanoma is a biopsy. This is a penetrative surgical procedure that involves higher costs but also incorporates risks of developing various infectious diseases (Lakhtakia et al., 2009). Thus, the usual clinical practice of melanoma diagnosis is visual inspection using Dermoscopy by dermatologists or specially trained clinicians. This approach presents challenges, primarily due to its resource-intensive nature in terms of time and cost. This method's accuracy of melanoma diagnosis is approximately

We thank the reviewers for their time and valuable feedback. Below, we clarify a number of important points raised by the reviewers. Reviewers raise concern on multi-modal embeddings. We will highlight this limitation in Sec. R3 suggests that "the authors can adapt the FOL queries to other We argue the differences in tasks and setups below.

Recent advancements in Large Language Models (LLMs) and their increased accessibility have made it easier than ever for students to automatically generate texts, posing new challenges for educational institutions. To enforce norms of academic integrity and ensure students' learning, learning analytics methods to automatically detect LLM-generated text appear increasingly appealing. This paper benchmarks the performance of different state-of-the-art detectors in educational contexts, introducing a novel dataset, called Generative Essay Detection in Education (GEDE), containing over 900 student-written essays and over 12,500 LLM-generated essays from various domains. To capture the diversity of LLM usage practices in generating text, we propose the concept of contribution levels, representing students' contribution to a given assignment. These levels range from purely human-written texts, to slightly LLM-improved versions, to fully LLM-generated texts, and finally to active attacks on the detector by "humanizing" generated texts. We show that most detectors struggle to accurately classify texts of intermediate student contribution levels, like LLM-improved human-written texts. Detectors are particularly likely to produce false positives, which is problematic in educational settings where false suspicions can severely impact students' lives. Our dataset, code, and additional supplementary materials are publicly available at https://github.com/lukasgehring/Assessing-LLM-Text-Detection-in-Educational-Contexts.

Reasoning models have achieved remarkable performance on tasks like math and logical reasoning thanks to their ability to search during reasoning. However, they still suffer from overthinking, often performing unnecessary reasoning steps even after reaching the correct answer. This raises the question: can models evaluate the correctness of their intermediate answers during reasoning? In this work, we study whether reasoning models encode information about answer correctness through probing the model's hidden states. The resulting probe can verify intermediate answers with high accuracy and produces highly calibrated scores. Additionally, we find models' hidden states encode correctness of future answers, enabling early prediction of the correctness before the intermediate answer is fully formulated. We then use the probe as a verifier to decide whether to exit reasoning at intermediate answers during inference, reducing the number of inference tokens by 24\% without compromising performance. These findings confirm that reasoning models do encode a notion of correctness yet fail to exploit it, revealing substantial untapped potential to enhance their efficiency.

False arrhythmia alarms in intensive care units (ICUs) are a significant challenge, contributing to alarm fatigue and potentially compromising patient safety. Ventricular tachycardia (VT) alarms are particularly difficult to detect accurately due to their complex nature. This paper presents a machine learning approach to reduce false VT alarms using the VTaC dataset, a benchmark dataset of annotated VT alarms from ICU monitors. We extract time-domain and frequency-domain features from waveform data, preprocess the data, and train deep learning models to classify true and false VT alarms. Our results demonstrate high performance, with ROC-AUC scores exceeding 0.96 across various training configurations. This work highlights the potential of machine learning to improve the accuracy of VT alarm detection in clinical settings.

Large language models (LLMs) have shown considerable success in a range of domain-specific tasks, especially after fine-tuning. However, fine-tuning with real-world data usually leads to privacy risks, particularly when the fine-tuning samples exist in the pre-training data. To avoid the shortcomings of real data, developers often employ methods to automatically generate synthetic data for fine-tuning, as data generated by traditional models are often far away from the real-world pertaining data. However, given the advanced capabilities of LLMs, the distinction between real data and LLM-generated data has become negligible, which may also lead to privacy risks like real data. In this paper, we present an empirical analysis of this underexplored issue by investigating a key question: "Does fine-tuning with LLM-generated data enhance privacy, or does it pose additional privacy risks?" Based on the structure of LLM's generated data, our research focuses on two primary approaches to fine-tuning with generated data: supervised fine-tuning with unstructured generated data and self-instruct tuning. The number of successful Personal Information Identifier (PII) extractions for Pythia after fine-tuning our generated data raised over $20\%$. Furthermore, the ROC-AUC score of membership inference attacks for Pythia-6.9b after self-instruct methods also achieves more than $40\%$ improvements on ROC-AUC score than base models. The results indicate the potential privacy risks in LLMs when fine-tuning with the generated data.

Hyperspectral sensing is a valuable tool for detecting anomalies and distinguishing between materials in a scene. Hyperspectral anomaly detection (HS-AD) helps characterize the captured scenes and separates them into anomaly and background classes. It is vital in agriculture, environment, and military applications such as RSTA (reconnaissance, surveillance, and target acquisition) missions. We previously designed an equal voting ensemble of hyperspectral unmixing and three unsupervised HS-AD algorithms. We later utilized a supervised classifier to determine the weights of a voting ensemble, creating a hybrid of heterogeneous unsupervised HS-AD algorithms with a supervised classifier in a model stacking, which improved detection accuracy. However, supervised classification methods usually fail to detect novel or unknown patterns that substantially deviate from those seen previously. In this work, we evaluate our technique and other supervised and unsupervised methods using general hyperspectral data to provide new insights.

Data sets with imbalanced class sizes, often where one class size is much smaller than that of others, occur extremely often in various applications, including those with biological foundations, such as drug discovery and disease diagnosis. Thus, it is extremely important to be able to identify data elements of classes of various sizes, as a failure to detect can result in heavy costs. However, many data classification algorithms do not perform well on imbalanced data sets as they often fail to detect elements belonging to underrepresented classes. In this paper, we propose the BTDT-MBO algorithm, incorporating Merriman-Bence-Osher (MBO) techniques and a bidirectional transformer, as well as distance correlation and decision threshold adjustments, for data classification problems on highly imbalanced molecular data sets, where the sizes of the classes vary greatly. The proposed method not only integrates adjustments in the classification threshold for the MBO algorithm in order to help deal with the class imbalance, but also uses a bidirectional transformer model based on an attention mechanism for self-supervised learning. Additionally, the method implements distance correlation as a weight function for the similarity graph-based framework on which the adjusted MBO algorithm operates. The proposed model is validated using six molecular data sets, and we also provide a thorough comparison to other competing algorithms. The computational experiments show that the proposed method performs better than competing techniques even when the class imbalance ratio is very high.

In this paper, we introduce a simple yet effective tabular data watermarking mechanism with statistical guarantees. We show theoretically that the proposed watermark can be effectively detected, while faithfully preserving the data fidelity, and also demonstrates appealing robustness against additive noise attack. The general idea is to achieve the watermarking through a strategic embedding based on simple data binning. Specifically, it divides the feature's value range into finely segmented intervals and embeds watermarks into selected ``green list" intervals. To detect the watermarks, we develop a principled statistical hypothesis-testing framework with minimal assumptions: it remains valid as long as the underlying data distribution has a continuous density function. The watermarking efficacy is demonstrated through rigorous theoretical analysis and empirical validation, highlighting its utility in enhancing the security of synthetic and real-world datasets.

Recent genome-wide association studies (GWAS) have uncovered the genetic basis of complex traits, but show an under-representation of non-European descent individuals, underscoring a critical gap in genetic research. Here, we assess whether we can improve disease prediction across diverse ancestries using multiomic data. We evaluate the performance of Group-LASSO INTERaction-NET (glinternet) and pretrained lasso in disease prediction focusing on diverse ancestries in the UK Biobank. Models were trained on data from White British and other ancestries and validated across a cohort of over 96,000 individuals for 8 diseases. Out of 96 models trained, we report 16 with statistically significant incremental predictive performance in terms of ROC-AUC scores (p-value < 0.05), found for diabetes, arthritis, gall stones, cystitis, asthma and osteoarthritis. For the interaction and pretrained models that outperformed the baseline, the PRS score was the primary driver behind prediction. Our findings indicate that both interaction terms and pre-training can enhance prediction accuracy but for a limited set of diseases and moderate improvements in accuracy.