Magnetic Resonance Imaging (MRI) is a powerful medical imaging modality that offers diagnostic information without harmful ionizing radiation.

Magnetic Resonance Imaging (MRI) is a powerful medical imaging modality that offers diagnostic information without harmful ionizing radiation. Measurements are collected in multiple shots, or readouts, and in each shot, data along a smooth trajectory is sampled.Conventional MRI data acquisition relies on sampling k-space row-by-row in short intervals, which is slow and inefficient. More efficient, non-Cartesian sampling trajectories (e.g., Spirals) use longer data readout intervals, but are more susceptible to magnetic field inhomogeneities, leading to off-resonance artifacts. Spiral trajectories cause off-resonance blurring in the image, and the mathematics of this blurring resembles that of optical blurring, where magnetic field variation corresponds to depth and readout duration to aperture size. Off-resonance blurring is a system issue with a physics-based, accurate forward model.

Recent studies have shown that deep learning (DL) models can skillfully predict the El Ni\~no-Southern Oscillation (ENSO) forecasts over 1.5 years ahead. However, concerns regarding the reliability of predictions made by DL methods persist, including potential overfitting issues and lack of interpretability. Here, we propose ResoNet, a DL model that combines convolutional neural network (CNN) and Transformer architectures. This hybrid architecture design enables our model to adequately capture local SSTA as well as long-range inter-basin interactions across oceans. We show that ResoNet can robustly predict ESNO at lead times between 19 and 26 months, thus outperforming existing approaches in terms of the forecast horizon. According to an explainability method applied to ResoNet predictions of El Ni\~no and La Ni\~na events from 1- to 18-month lead, we find that it predicts the Ni\~no3.4 index based on multiple physically reasonable mechanisms, such as the Recharge Oscillator concept, Seasonal Footprint Mechanism, and Indian Ocean capacitor effect. Moreover, we demonstrate that for the first time, the asymmetry between El Ni\~no and La Ni\~na development can be captured by ResoNet. Our results could help alleviate skepticism about applying DL models for ENSO prediction and encourage more attempts to discover and predict climate phenomena using AI methods.