Quantitative susceptibility maps from magnetic resonance images can provide both prognostic and diagnostic information in multiple sclerosis, a neurodegenerative disease characterized by the formation of lesions in white matter brain tissue. In particular, susceptibility maps provide adequate contrast to distinguish between "rim" lesions, surrounded by deposited paramagnetic iron, and "non-rim" lesion types. These paramagnetic rim lesions (PRLs) are an emerging biomarker in multiple sclerosis. Much effort has been devoted to both detection and segmentation of such lesions to monitor longitudinal change. As paramagnetic rim lesions are rare, addressing this problem requires confronting the class imbalance between rim and non-rim lesions. W e produce synthetic quantitative susceptibility maps of paramagnetic rim lesions and show that inclusion of such synthetic data improves classifier performance and provide a multi-channel extension to generate accompanying contrasts and probabilistic segmentation maps. W e exploit the projection capability of our trained generative network to demonstrate a novel denoising approach that allows us to train on ambiguous rim cases and substantially increase the minority class. W e show that both synthetic lesion synthesis and our proposed rim lesion label denoising method best approximate the unseen rim lesion distribution and improve detection in a clinically interpretable manner . W e release our code and generated data at https://github.com/agr78/PRLx-GAN

The Nearest Neighbor model is the $\textit{de facto}$ thermodynamic model of RNA secondary structure formation and is a cornerstone of RNA structure prediction and sequence design. The current functional form (Turner 2004) contains $\approx13,000$ underlying thermodynamic parameters, and fitting these to both experimental and structural data is computationally challenging. Here, we leverage recent advances in $\textit{differentiable folding}$, a method for directly computing gradients of the RNA folding algorithms, to devise an efficient, scalable, and flexible means of parameter optimization that uses known RNA structures and thermodynamic experiments. Our method yields a significantly improved parameter set that outperforms existing baselines on all metrics, including an increase in the average predicted probability of ground-truth sequence-structure pairs for a single RNA family by over 23 orders of magnitude. Our framework provides a path towards drastically improved RNA models, enabling the flexible incorporation of new experimental data, definition of novel loss terms, large training sets, and even treatment as a module in larger deep learning pipelines. We make available a new database, RNAometer, with experimentally-determined stabilities for small RNA model systems.

This document provides responses to the FDA's request for public comments (Docket No FDA 2023 N 4853) on the role of digital health technologies (DHTs) in detecting prediabetes and undiagnosed type 2 diabetes. It explores current DHT applications in prevention, detection, treatment and reversal of prediabetes, highlighting AI chatbots, online forums, wearables and mobile apps. The methods employed by DHTs to capture health signals like glucose, diet, symptoms and community insights are outlined. Key subpopulations that could benefit most from remote screening tools include rural residents, minority groups, high-risk individuals and those with limited healthcare access. Capturable high-impact risk factors encompass glycemic variability, cardiovascular parameters, respiratory health, blood biomarkers and patient reported symptoms. An array of non-invasive monitoring tools are discussed, although further research into their accuracy for diverse groups is warranted. Extensive health datasets providing immense opportunities for AI and ML based risk modeling are presented. Promising techniques leveraging EHRs, imaging, wearables and surveys to enhance screening through AI and ML algorithms are showcased. Analysis of social media and streaming data further allows disease prediction across populations. Ongoing innovation focused on inclusivity and accessibility is highlighted as pivotal in unlocking DHTs potential for transforming prediabetes and diabetes prevention and care.

Acute Kidney Injury (AKI), a sudden decline in kidney function, is associated with increased mortality, morbidity, length of stay, and hospital cost. Since AKI is sometimes preventable, there is great interest in prediction. Most existing studies consider all patients and therefore restrict to features available in the first hours of hospitalization. Here, the focus is instead on rehospitalized patients, a cohort in which rich longitudinal features from prior hospitalizations can be analyzed. Our objective is to provide a risk score directly at hospital re-entry. Gradient boosting, penalized logistic regression (with and without stability selection), and a recurrent neural network are trained on two years of adult inpatient EHR data (3,387 attributes for 34,505 patients who generated 90,013 training samples with 5,618 cases and 84,395 controls). Predictions are internally evaluated with 50 iterations of 5-fold grouped cross-validation with special emphasis on calibration, an analysis of which is performed at the patient as well as hospitalization level. Error is assessed with respect to diagnosis, race, age, gender, AKI identification method, and hospital utilization. In an additional experiment, the regularization penalty is severely increased to induce parsimony and interpretability. Predictors identified for rehospitalized patients are also reported with a special analysis of medications that might be modifiable risk factors. Insights from this study might be used to construct a predictive tool for AKI in rehospitalized patients. An accurate estimate of AKI risk at hospital entry might serve as a prior for an admitting provider or another predictive algorithm.

Research by members of the Department of Computer Science at Rutgers, and by their collaborators, is organized within the Laboratory for Computer Science research(LCSR). AI and AI-related applications are the major area of research within LCSR, with about forty people-faculty, staff and graduate students-currently involved in various aspects of AI research.