In single-cell perturbation prediction, a central task is to forecast the effects of perturbing a gene unseen in the training data. The efficacy of such predictions depends on two factors: (1) the similarity of the target gene to those covered in the training data, which informs model (epistemic) uncertainty, and (2) the quality of the corresponding training data, which reflects data (aleatoric) uncertainty. Both factors are critical for determining the reliability of a prediction, particularly as gene perturbation is an inherently stochastic biochemical process. In this paper, we propose PRESCRIBE (PREdicting Single-Cell Response wIth Bayesian Estimation), a multivariate deep evidential regression framework designed to measure both sources of uncertainty jointly. Our analysis demonstrates that PRESCRIBE effectively estimates a confidence score for each prediction, which strongly correlates with its empirical accuracy. This capability enables the filtering of untrustworthy results, and in our experiments, it achieves steady accuracy improvements of over 3% compared to comparable baselines.

Fast Fourier Transforms (FFT) are widely used to reduce memory and computational costs in deep learning. However, existing implementations, including standard FFT and real FFT (rFFT), cannot achieve true in-place computation.

We introduce Filter Like You Test (FLYT), an algorithm for curating large-scale vision-language datasets that learns the usefulness of each data point as a pretraining example. FLYT trains a scoring model that learns to weigh each example's features using gradient signals from downstream tasks training sets. Based on FLYT, we implement Mixing-FLYT (M-FLYT), which takes the per-example scores generated by different scoring methods as features, and learns to unify them into a single score. FLYT naturally produces a distribution over the training examples, which we leverage through Soft Cap Sampling (SCS), a strategy for obtaining a filtered pretraining dataset from per-example probabilities that samples examples while preventing over-representation through a repetition penalty. Using these methods, we achieve 40.1% ImageNet zero-shot accuracy on the DataComp medium scale filtering benchmark, a 2% absolute accuracy increase over all previous results and a 5.5% increase over results that--like us--use only public resources. Our approach also yields 37.7% on the average of 38 DataComp evaluation tasks, outperforming previous public-resource approaches by 0.4%.

Question: Do the main claims made in the abstract and introduction accurately reflect the3 paper's contributions and scope?4 Answer: [Yes]5 Justification: These claims are substantiated within the paper through detailed descriptions6 of the dataset's structure and the methodologies employed for each analysis task. The answer NA means that the abstract and introduction do not include the claims11 made in the paper.12 The abstract and/or introduction should clearly state the claims made, including the13 contributions made in the paper and important assumptions and limitations. ANo or14 NA answer to this question will not be perceived well by the reviewers.15 The claims made should match theoretical and experimental results, and reflect how16 much the results can be expected to generalize to other settings.17

In recent years, face-based deep-learning gaze estimation methods have achieved significant advancements. However, while face images provide supplementary information beneficial for gaze inference, the substantial extraneous information they contain also increases the risk of overfitting during model training and compromises generalization capability. To alleviate this problem, we propose the 3DPE-Gaze framework, explicitly modeling 3D facial priors for feature decoupling and generalized gaze estimation. The 3DPE-Gaze framework consists of two core modules: the 3DGeometric Prior Module (3DGP) incorporating the FLAME model to parameterize facial structures and gaze-irrelevant facial appearances while extracting gaze features; the Semantic Concept Alignment Module (SCAM) separates gaze-related and unrelated concepts through CLIP-guided contrastive learning. Finally, the 3DPE-Gaze framework combines 3D facial landmark as prior for generalized gaze estimation. Experimental results show that 3DPE-Gaze outperforms existing state-of-the-art methods on four major cross-domain tasks, with particularly outstanding performance in challenging scenarios such as lighting variations, extreme head poses, and glasses occlusion.

Scenario-based testing is essential for validating the performance of autonomous driving (AD) systems. However, such testing is limited by the scarcity of longtailed, safety-critical scenarios in existing datasets collected in the real world. To tackle the data issue, we propose the Adv-BMT framework, which augments realworld scenarios with diverse and realistic adversarial traffic interactions. The core component of Adv-BMT is a bidirectional motion transformer (BMT) model to perform inverse traffic motion predictions, which takes agent information in the last time step of the scenario as input, and reconstruct the traffic in the inverse of chronological order until the initial time step. The Adv-BMT framework is a twostaged pipeline: it first conducts adversarial initializations and then inverse motion predictions. Different from previous work, we do not need any collision data for pretraining, and are able to generate realistic and diverse collision interactions. Our experimental results validate the quality of generated collision scenarios by Adv-BMT: training in our augmented dataset would reduce episode collision rates by 20%. Demo and code are available at https://metadriverse.github.io/

Simpson's paradox poses a challenge in probabilistic inference and decisionmaking. Our study revisits the paradox by re-estimating its frequency with an unbiased data generation process and reaffirms that it is not an artifact of deficient data collection. Thus, it can lead to incorrect recommendations in fields as diverse as statistics, psychology, and artificial intelligence. We show that the paradox can be resolved by assuming a minimal -- though not necessarily observed -- common cause (or screening) variable for the involved random variables. In our approach, conditioning on this minimal common cause establishes the correct association between events, which coincides with the conditioning (i.e., fine-grained) option of the original Simpson paradox. This resolution applies to both discrete cases of binary variables and continuous settings modeled by Gaussian variables. For a non-minimal common cause, the resolution of the paradox is possible, but detailed knowledge of the common cause is required. Our findings extend traditional understandings of the paradox and offer practical guidance for resolving apparent contradictions in probabilistic inference, ultimately enhancing decision-making processes. This point is illustrated by several examples.

Bumble bees either become the larger and fertile queen or a smaller and sterile worker. More information Adding us as a Preferred Source in Google by using this link indicates that you would like to see more of our content in Google News results. Worker bees can alter the future of the colony's larvae. Breakthroughs, discoveries, and DIY tips sent six days a week. While every bumble bee colony has a queen, the process for becoming that queen bee may be a bit more democratic than monarchical.