Supervised Pix2Pix and unsupervised Cycle-consistency are two modes that dominate the field of medical image-to-image translation. However, neither modes are ideal. The Pix2Pix mode has excellent performance. But it requires paired and well pixel-wise aligned images, which may not always be achievable due to respiratory motion or anatomy change between times that paired images are acquired. The Cycle-consistency mode is less stringent with training data and works well on unpaired or misaligned images.

Supervised Pix2Pix and unsupervised Cycle-consistency are two modes that dominate the field of medical image-to-image translation. However, neither modes are ideal. The Pix2Pix mode has excellent performance. But it requires paired and well pixel-wise aligned images, which may not always be achievable due to respiratory motion or anatomy change between times that paired images are acquired. The Cycle-consistency mode is less stringent with training data and works well on unpaired or misaligned images.

We propose a framework for generating samples from a probability distribution that differs from the probability distribution of the training set. We use an adversarial process that simultaneously trains three networks, a generator and two discriminators. We refer to this new model as regularized generative adversarial network (RegGAN). We evaluate RegGAN on a synthetic dataset composed of gray scale images and we further show that it can be used to learn some pre-specified notions in topology (basic topology properties). The work is motivated by practical problems encountered while using generative methods in the art world.