Add a small icon before the "Welcome to our ice cream parlor!" text using the URL https://cdn-556

Neural Information Processing Systems http://nips.cc/

We genuinely appreciate all three reviewers' (#1,#2,#3,#4) valuable suggestions to strengthen our paper. More details are referred to Reviewer #3's Q2. We sincerely appreciate your suggestion and will revise the caption in figure 4 for better readability. Reply: It is a great observation. Thus, IL appears to be a main contributor for L2O generalizing across different optimizees.

Feature attribution is the dominant paradigm for explaining deep neural networks. However, most existing methods only loosely reflect the model's prediction-making process, thereby merely white-painting the black box. We argue that explanatory alignment is a key aspect of trustworthiness in prediction tasks: explanations must be directly linked to predictions, rather than serving as post-hoc rationalizations. We present model readability as a design principle enabling alignment, and PiNets as a modeling framework to pursue it in a deep learning context. PiNets are pseudo-linear networks that produce instance-wise linear predictions in an arbitrary feature space, making them linearly readable. We illustrate their use on image classification and segmentation tasks, demonstrating how PiNets produce explanations that are faithful across multiple criteria in addition to alignment.

Abstract--General-purpose large language models (LLMs) have demonstrated remarkable generative and reasoning capabilities but remain limited in healthcare and caregiving applications due to two key deficiencies: factual unreliability and a lack of empathetic communication. These shortcomings pose significant risks in sensitive contexts where users, particularly nonprofessionals and caregivers, seek medically relevant guidance or emotional reassurance. T o address these challenges, we introduce a Direct Preference Optimization (DPO)-based alignment framework designed to improve factual correctness, semantic coherence, and human-centric qualities such as empathy, politeness, and simplicity in caregiver-patient dialogues. Our approach fine-tunes domain-adapted Large Language Models (LLMs) using pairwise preference data, where preferred responses reflect supportive and accessible communication styles while rejected ones represent prescriptive or overly technical tones. Empirical evaluations across multiple open and proprietary LLMs show that our DPO-tuned models achieve higher semantic alignment, improved factual accuracy, and stronger human-centric evaluation scores compared to baseline and commercial alternatives such as Google's medical dialogue systems. These improvements demonstrate that preference-based alignment offers a scalable and transparent pathway toward developing trustworthy, empathetic, and clinically informed AI assistants for caregiver and healthcare communication. Caring for individuals with chronic or neuro-degenerative conditions such as Alzheimer's disease and dementia requires not only clinical coordination but also constant emotional resilience. Family caregivers and care partners often become the primary interpreters of medical information, navigating complex treatment decisions, behavioral changes, and communication challenges on a daily basis. LLMs have rapidly become integrated into everyday life. They can explain complex ideas in plain language, adjust to a user's tone, and offer a sense of understanding that static websites cannot. For caregivers seeking clear, kind, and quick answers, these systems can feel like an always-available companion in moments of doubt or stress.

Automatic medical text simplification plays a key role in improving health literacy by making complex biomedical research accessible to diverse readers. However, most existing resources assume a single generic audience, overlooking the wide variation in medical literacy and information needs across user groups. To address this limitation, we introduce PERCS (Persona-guided Controllable Summarization), a dataset of biomedical abstracts paired with summaries tailored to four personas: Laypersons, Premedical Students, Non-medical Researchers, and Medical Experts. These personas represent different levels of medical literacy and information needs, emphasizing the need for targeted, audience-specific summarization. Each summary in PERCS was reviewed by physicians for factual accuracy and persona alignment using a detailed error taxonomy. Technical validation shows clear differences in readability, vocabulary, and content depth across personas. Along with describing the dataset, we benchmark four large language models on PERCS using automatic evaluation metrics that assess comprehensiveness, readability, and faithfulness, establishing baseline results for future research. The dataset, annotation guidelines, and evaluation materials are publicly available to support research on persona-specific communication and controllable biomedical summarization.