Matched filters are widely used to localise signal patterns due to their high efficiency and interpretability. However, their effectiveness deteriorates for low signal-to-noise ratio (SNR) signals, such as those recorded on edge devices, where prominent noise patterns can closely resemble the target within the limited length of the filter. One example is the ear-electrocardiogram (ear-ECG), where the cardiac signal is attenuated and heavily corrupted by artefacts. To address this, we propose the Sequential Matched Filter (SMF), a paradigm that replaces the conventional single matched filter with a sequence of filters designed by a Reinforcement Learning agent. By formulating filter design as a sequential decision-making process, SMF adaptively design signal-specific filter sequences that remain fully interpretable by revealing key patterns driving the decision-making. The proposed SMF framework has strong potential for reliable and interpretable clinical decision support, as demonstrated by its state-of-the-art R-peak detection and physiological state classification performance on two challenging real-world ECG datasets. The proposed formulation can also be extended to a broad range of applications that require accurate pattern localisation from noise-corrupted signals.

Electrocardiograms (ECGs) are essential for monitoring cardiac health, allowing clinicians to analyze heart rate variability (HRV), detect abnormal rhythms, and diagnose cardiovascular diseases. However, ECG signals, especially those from wearable devices, are often affected by noise artifacts caused by motion, muscle activity, or device-related interference. These artifacts distort R-peaks and the characteristic QRS complex, making HRV analysis unreliable and increasing the risk of misdiagnosis. Despite this, the few existing studies on ECG noise detection have primarily focused on a single dataset, limiting the understanding of how well noise detection models generalize across different datasets. In this paper, we investigate the generalizability of noise detection in ECG using a novel HRV-based approach through cross-dataset experiments on four datasets. Our results show that machine learning achieves an average accuracy of over 90\% and an AUPRC of more than 0.9. These findings suggest that regardless of the ECG data source or the type of noise, the proposed method maintains high accuracy even on unseen datasets, demonstrating the feasibility of generalizability.

Cardiovascular diseases are best diagnosed using multiple modalities that assess both the heart's electrical and mechanical functions. While effective, imaging techniques like echocardiography and nuclear imaging are costly and not widely accessible. More affordable technologies, such as simultaneous electrocardiography (ECG) and phonocardiography (PCG), may provide valuable insights into electromechanical coupling and could be useful for prescreening in low-resource settings. Using physical stress test data from the EPHNOGRAM ECG-PCG dataset, collected from 23 healthy male subjects (age: 25.4+/-1.9 yrs), we investigated electromechanical intervals (RR, QT, systolic, and diastolic) and their interactions during exercise, along with hysteresis between cardiac electrical activity and mechanical responses. Time delay analysis revealed distinct temporal relationships between QT, systolic, and diastolic intervals, with RR as the primary driver. The diastolic interval showed near-synchrony with RR, while QT responded to RR interval changes with an average delay of 10.5s, and the systolic interval responded more slowly, with an average delay of 28.3s. We examined QT-RR, systolic-RR, and diastolic-RR hysteresis, finding narrower loops for diastolic RR and wider loops for systolic RR. Significant correlations (average:0.75) were found between heart rate changes and hysteresis loop areas, suggesting the equivalent circular area diameter as a promising biomarker for cardiac function under exercise stress. Deep learning models, including Long Short-Term Memory and Convolutional Neural Networks, estimated the QT, systolic, and diastolic intervals from RR data, confirming the nonlinear relationship between RR and other intervals. Findings highlight a significant cardiac memory effect, linking ECG and PCG morphology and timing to heart rate history.

Recent developments in Large Language Models (LLMs) have demonstrated their remarkable capabilities across a range of tasks. Questions, however, persist about the nature of LLMs and their potential to integrate common-sense human knowledge when performing tasks involving information about the real physical world. This paper delves into these questions by exploring how LLMs can be extended to interact with and reason about the physical world through IoT sensors and actuators, a concept that we term "Penetrative AI". The paper explores such an extension at two levels of LLMs' ability to penetrate into the physical world via the processing of sensory signals. Our preliminary findings indicate that LLMs, with ChatGPT being the representative example in our exploration, have considerable and unique proficiency in employing the embedded world knowledge for interpreting IoT sensor data and reasoning over them about tasks in the physical realm. Not only this opens up new applications for LLMs beyond traditional text-based tasks, Figure 1: Overview of Penetrative AI. but also enables new ways of incorporating human knowledge in cyber-physical systems.

Deep neural networks have become increasingly popular for analyzing ECG data because of their ability to accurately identify cardiac conditions and hidden clinical factors. However, the lack of transparency due to the black box nature of these models is a common concern. To address this issue, explainable AI (XAI) methods can be employed. In this study, we present a comprehensive analysis of post-hoc XAI methods, investigating the local (attributions per sample) and global (based on domain expert concepts) perspectives. We have established a set of sanity checks to identify sensible attribution methods, and we provide quantitative evidence in accordance with expert rules. This dataset-wide analysis goes beyond anecdotal evidence by aggregating data across patient subgroups. Furthermore, we demonstrate how these XAI techniques can be utilized for knowledge discovery, such as identifying subtypes of myocardial infarction. We believe that these proposed methods can serve as building blocks for a complementary assessment of the internal validity during a certification process, as well as for knowledge discovery in the field of ECG analysis.

Objective: Gaussian Processes (GP)-based filters, which have been effectively used for various applications including electrocardiogram (ECG) filtering can be computationally demanding and the choice of their hyperparameters is typically ad hoc. Methods: We develop a data-driven GP filter to address both issues, using the notion of the ECG phase domain -- a time-warped representation of the ECG beats onto a fixed number of samples and aligned R-peaks, which is assumed to follow a Gaussian distribution. Under this assumption, the computation of the sample mean and covariance matrix is simplified, enabling an efficient implementation of the GP filter in a data-driven manner, with no ad hoc hyperparameters. The proposed filter is evaluated and compared with a state-of-the-art wavelet-based filter, on the PhysioNet QT Database. The performance is evaluated by measuring the signal-to-noise ratio (SNR) improvement of the filter at SNR levels ranging from -5 to 30dB, in 5dB steps, using additive noise. For a clinical evaluation, the error between the estimated QT-intervals of the original and filtered signals is measured and compared with the benchmark filter. Results: It is shown that the proposed GP filter outperforms the benchmark filter for all the tested noise levels. It also outperforms the state-of-the-art filter in terms of QT-interval estimation error bias and variance. Conclusion: The proposed GP filter is a versatile technique for preprocessing the ECG in clinical and research applications, is applicable to ECG of arbitrary lengths and sampling frequencies, and provides confidence intervals for its performance.

Abstract--We describe how some problems (interpretability, lack of object-orientedness) of modern deep networks potentially could be solved by adapting a biologically plausible saccadic mechanism of perception. A sketch of such a saccadic vision model is proposed. Proof of concept experimental results are provided to support the proposed approach. One of the most human-readable representations of a visual Deep convolutional networks are often used today in applied scene is the semantic scene graph: if it is present, the task problems as one of the basic components of learning systems. of generating the text describing the scene is trivial [7]. The On some tasks, for example, the task of modeling faces, it is nodes of such a graph are usually nouns that name objects possible to achieve representations with good interpretability on the stage. The node can be assigned its coordinates on the [2].

In recent years, physiological signal based authentication has shown great promises,for its inherent robustness against forgery. Electrocardiogram (ECG) signal, being the most widely studied biosignal, has also received the highest level of attention in this regard. It has been proven with numerous studies that by analyzing ECG signals from different persons, it is possible to identify them, with acceptable accuracy. In this work, we present, EDITH, a deep learning-based framework for ECG biometrics authentication system. Moreover, we hypothesize and demonstrate that Siamese architectures can be used over typical distance metrics for improved performance. We have evaluated EDITH using 4 commonly used datasets and outperformed the prior works using less number of beats. EDITH performs competitively using just a single heartbeat (96-99.75% accuracy) and can be further enhanced by fusing multiple beats (100% accuracy from 3 to 6 beats). Furthermore, the proposed Siamese architecture manages to reduce the identity verification Equal Error Rate (EER) to 1.29%. A limited case study of EDITH with real-world experimental data also suggests its potential as a practical authentication system.

The high rate of false alarms in intensive care units (ICUs) is one of the top challenges of using medical technology in hospitals. These false alarms are often caused by patients' movements, detachment of monitoring sensors, or different sources of noise and interference that impact the collected signals from different monitoring devices. In this paper, we propose a novel set of high-level features based on unsupervised feature learning technique in order to effectively capture the characteristics of different arrhythmia in electrocardiogram (ECG) signal and differentiate them from irregularity in signals due to different sources of signal disturbances. This unsupervised feature learning technique, first extracts a set of low-level features from all existing heart cycles of a patient, and then clusters these segments for each individual patient to provide a set of prominent high-level features. The objective of the clustering phase is to enable the classification method to differentiate between the high-level features extracted from normal and abnormal cycles (i.e., either due to arrhythmia or different sources of distortions in signal) in order to put more attention to the features extracted from abnormal portion of the signal that contribute to the alarm. The performance of this method is evaluated using the 2015 PhysioNet/Computing in Cardiology Challenge dataset for reducing false arrhythmia alarms in the ICUs. As confirmed by the experimental results, the proposed method offers a considerable performance in terms of accuracy, sensitivity and specificity of alarm detection only using a few high-level features that are extracted from one single lead ECG signal.

The artificial neural network shows powerful ability of inference, but it is still criticized for lack of interpretability and prerequisite needs of big dataset. This paper proposes the Rule-embedded Neural Network (ReNN) to overcome the shortages. ReNN first makes local-based inferences to detect local patterns, and then uses rules based on domain knowledge about the local patterns to generate rule-modulated map. After that, ReNN makes global-based inferences that synthesizes the local patterns and the rule-modulated map. To solve the optimization problem caused by rules, we use a two-stage optimization strategy to train the ReNN model. By introducing rules into ReNN, we can strengthen traditional neural networks with long-term dependencies which are difficult to learn with limited empirical dataset, thus improving inference accuracy. The complexity of neural networks can be reduced since long-term dependencies are not modeled with neural connections, and thus the amount of data needed to optimize the neural networks can be reduced. Besides, inferences from ReNN can be analyzed with both local patterns and rules, and thus have better interpretability. In this paper, ReNN has been validated with a time-series detection problem.