Deep learning models have become increasingly large and complex, resulting in higher memory consumption and computational demands. Consequently, model loading times and initial inference latency have increased, posing significant challenges in mobile and latency-sensitive environments where frequent model loading and unloading are required, which directly impacts user experience. While Knowledge Distillation (KD) offers a solution by compressing large teacher models into smaller student ones, it often comes at the cost of reduced performance. To address this trade-off, we propose Progressive Weight Loading (PWL), a novel technique that enables fast initial inference by first deploying a lightweight student model, then incrementally replacing its layers with those of a pre-trained teacher model. To support seamless layer substitution, we introduce a training method that not only aligns intermediate feature representations between student and teacher layers, but also improves the overall output performance of the student model. Our experiments on VGG, ResNet, and ViT architectures demonstrate that models trained with PWL maintain competitive distillation performance and gradually improve accuracy as teacher layers are loaded--matching the final accuracy of the full teacher model without compromising initial inference speed. This makes PWL particularly suited for dynamic, resource-constrained deployments where both responsiveness and performance are critical.

In transmission X-ray microscopy (TXM) systems, the rotation of a scanned sample might be restricted to a limited angular range to avoid collision to other system parts or high attenuation at certain tilting angles. Image reconstruction from such limited angle data suffers from artifacts due to missing data. In this work, deep learning is applied to limited angle reconstruction in TXMs for the first time. With the challenge to obtain sufficient real data for training, training a deep neural network from synthetic data is investigated. Particularly, the U-Net, the state-of-the-art neural network in biomedical imaging, is trained from synthetic ellipsoid data and multi-category data to reduce artifacts in filtered back-projection (FBP) reconstruction images. The proposed method is evaluated on synthetic data and real scanned chlorella data in $100^\circ$ limited angle tomography. For synthetic test data, the U-Net significantly reduces root-mean-square error (RMSE) from $2.55 \times 10^{-3}$ {\mu}m$^{-1}$ in the FBP reconstruction to $1.21 \times 10^{-3}$ {\mu}m$^{-1}$ in the U-Net reconstruction, and also improves structural similarity (SSIM) index from 0.625 to 0.920. With penalized weighted least square denoising of measured projections, the RMSE and SSIM are further improved to $1.16 \times 10^{-3}$ {\mu}m$^{-1}$ and 0.932, respectively. For real test data, the proposed method remarkably improves the 3-D visualization of the subcellular structures in the chlorella cell, which indicates its important value for nano-scale imaging in biology, nanoscience and materials science.