The device made by Flow Neuroscience is approved by the FDA and could help people get off antidepressants--but it costs $2,200. An at-home wearable for the treatment of depression is now available by prescription in the US. With roughly one in six American adults taking an antidepressant medication, Swedish firm Flow Neuroscience is positioning its device as an alternative to traditional drugs. But at the current four-figure price tag, it might take a while for the futuristic-looking headset to catch on with patients. Worn on the forehead for 30 minutes a day and operated with an app, the device provides low-intensity electrical stimulation to the left frontal lobe of the brain, an area involved in regulating mood and emotions.

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Cleveland Clinic launched Zipline drone delivery for shelf-stable prescriptions near Beachwood, Ohio. Patients track orders via MyChart as drones lower meds by tether.

Scaling laws are typically fit using a family of models with a narrow range of frozen hyperparameter choices. In this work we study scaling laws using multiple architectural shapes and hyperparameter choices, highlighting their impact on resulting prescriptions. As a primary artifact of our research, we release the Gemstones: an open-source scaling law dataset, consisting of over 4000 checkpoints from transformers with up to 2 billion parameters and diverse architectural shapes; including ablations over learning rate and cooldown. Our checkpoints enable more complex studies of scaling, such as analyzing the relationship between width and depth. By examining our model suite, we find that the prescriptions of scaling laws can be highly sensitive to the experimental design process and the specific model checkpoints used during fitting.

Physical activity (PA) plays an important role in maintaining and improving health. Daily steps have been a key PA measure that is easily accessible with common wearable devices. However, methods are lacking to recommend a personalized optimal distribution of daily steps over a period of time for the best of certain health biomarkers. In this paper, we fill this void based on the data from the All of Us Research Program which includes months of step counts as well as repeated measurements of key health biomarkers. We develop a new offline reinforcement learning (RL) algorithm to learn personalized and optimal PA distributions associated with cardiometabolic risk, where the action is a function representing the daily step distribution over a period of time. Simulation studies demonstrate the advantage of the proposed approach over existing continuous-action RL methods. The learned optimal policy from the All of Us data generally suggests people take more daily steps and also follow a more consistent pattern of PA over time while offering tailored recommendations for subgroups in blood glucose level, body mass index, blood pressure, age, and sex.

Dense Associative Memory (DenseAM) is a promising family of AI architectures that is represented by a neural network performing temporal dynamics on an energy landscape. While hyperparameter transfer methods are well-studied for feed-forward networks, these methods have not been developed for settings in which weights are shared across layers and within the layer, which is common in DenseAMs. Additionally, DenseAMs utilize rapidly peaking activation functions that are rarely used in feed-forward architectures. The confluence of these aspects makes DenseAM a challenging framework for using existing methods for hyperparameter transfer. Our work initiates the development of hyperparameter transfer methods for this class of models. We derive explicit prescriptions for how the hyperparameters tuned on small models can be transferred to models trained at scale. We demonstrate excellent agreement between these theoretical findings and empirical results.

Although freely accessible, it is provided in individual files for each year, and is difficult to combine in order to analyze spatial or temporal trends.

A.1 Motivation For what purpose was the dataset created?

Wedemonstrate theproposed methodology onahypertension dataset,showingthatourprescribed treatment leadstoalarger reduction in the systolic blood pressure compared to a series of alternatives.