Environment Conservation Ocean Florida can't decide if its official saltwater mammal is a dolphin or a porpoise They are not the same animal. Dolphins (right) are more common in Florida, while porpoises (left) are spotted much less frequently. Breakthroughs, discoveries, and DIY tips sent six days a week. States have a surprising number of official symbols . While most people would expect them to have an official motto, seal, and flag, there can also be a state beverage, muffin, soil, fossil, and poem, to name a few.

The rapidly emerging field of deep learning-based computational pathology has demonstrated promise in developing objective prognostic models from histology whole slide images. However, most prognostic models are either based on histology or genomics alone and do not address how histology and genomics can be integrated to develop joint image-omic prognostic models. Additionally identifying explainable morphological and molecular descriptors from these models that govern such prognosis is of interest. We used multimodal deep learning to integrate gigapixel whole slide pathology images, RNA-seq abundance, copy number variation, and mutation data from 5,720 patients across 14 major cancer types. Our interpretable, weakly-supervised, multimodal deep learning algorithm is able to fuse these heterogeneous modalities for predicting outcomes and discover prognostic features from these modalities that corroborate with poor and favorable outcomes via multimodal interpretability. We compared our model with unimodal deep learning models trained on histology slides and molecular profiles alone, and demonstrate performance increase in risk stratification on 9 out of 14 cancers. In addition, we analyze morphologic and molecular markers responsible for prognostic predictions across all cancer types. All analyzed data, including morphological and molecular correlates of patient prognosis across the 14 cancer types at a disease and patient level are presented in an interactive open-access database (http://pancancer.mahmoodlab.org) to allow for further exploration and prognostic biomarker discovery. To validate that these model explanations are prognostic, we further analyzed high attention morphological regions in WSIs, which indicates that tumor-infiltrating lymphocyte presence corroborates with favorable cancer prognosis on 9 out of 14 cancer types studied.

Each new year brings a frisson of excitement among book lovers as they anticipate the happy hours ahead absorbed in a library's worth of fresh reads. And 2019 looks to be bumper year. To whet your appetite we've picked a selection of fiction titles from a range of established and new authors. The list is by no means exhaustive. It may not even end up tempting you.

Two captive harbour porpoises called Freja and Sif have helped to reveal that porpoises --and probably all cetaceans -- consciously adjust their heart rate to suit the length of a planned dive. By doing this, the animals optimise the rate at which they consume oxygen beforehand to match the intended depth and length of their dive. "Until now, we knew that the heart rates of porpoises and cetaceans in general correlate with different dive factors, such as dive duration, depth and exercise," says Siri Elmegaard of Aarhus University in Denmark, who led the research. "Now we can conclude that harbour porpoises have cognitive control of their heart rate." The discovery might also provide another explanation for how exposure to loud noise from shipping, sonar or subsea exploration harms cetaceans and possibly triggers strandings.