The integration of multi-modal data, such as pathological images and genomic data, is essential for understanding cancer heterogeneity and complexity for personalized treatments, as well as for enhancing survival predictions. Despite the progress made in integrating pathology and genomic data, most existing methods cannot mine the complex inter-modality relations thoroughly. Additionally, identifying explainable features from these models that govern preclinical discovery and clinical prediction is crucial for cancer diagnosis, prognosis, and therapeutic response studies. We propose PONET- a novel biological pathway-informed pathology-genomic deep model that integrates pathological images and genomic data not only to improve survival prediction but also to identify genes and pathways that cause different survival rates in patients. Empirical results on six of The Cancer Genome Atlas (TCGA) datasets show that our proposed method achieves superior predictive performance and reveals meaningful biological interpretations. The proposed method establishes insight into how to train biologically informed deep networks on multimodal biomedical data which will have general applicability for understanding diseases and predicting response and resistance to treatment.

Conventional 3D human pose estimation relies on first detecting 2D body keypoints and then solving the 2D to 3D correspondence problem.Despite the promising results, this learning paradigm is highly dependent on the quality of the 2D keypoint detector, which is inevitably fragile to occlusions and out-of-image absences.In this paper,we propose a novel Pose Orientation Net (PONet) that is able to robustly estimate 3D pose by learning orientations only, hence bypassing the error-prone keypoint detector in the absence of image evidence. For images with partially invisible limbs, PONet estimates the 3D orientation of these limbs by taking advantage of the local image evidence to recover the 3D pose.Moreover, PONet is competent to infer full 3D poses even from images with completely invisible limbs, by exploiting the orientation correlation between visible limbs to complement the estimated poses,further improving the robustness of 3D pose estimation.We evaluate our method on multiple datasets, including Human3.6M, MPII, MPI-INF-3DHP, and 3DPW. Our method achieves results on par with state-of-the-art techniques in ideal settings, yet significantly eliminates the dependency on keypoint detectors and the corresponding computation burden. In highly challenging scenarios, such as truncation and erasing, our method performs very robustly and yields much superior results as compared to state of the art,demonstrating its potential for real-world applications.

Transformer-based models have achieved great success in various NLP, vision, and speech tasks. However, the core of Transformer, the self-attention mechanism, has a quadratic time and memory complexity with respect to the sequence length, which hinders applications of Transformer-based models to long sequences. Many approaches have been proposed to mitigate this problem, such as sparse attention mechanisms, low-rank matrix approximations and scalable kernels, and token mixing alternatives to self-attention. We propose a novel Pooling Network (PoNet) for token mixing in long sequences with linear complexity. We design multi-granularity pooling and pooling fusion to capture different levels of contextual information and combine their interactions with tokens. On the Long Range Arena benchmark, PoNet significantly outperforms Transformer and achieves competitive accuracy, while being only slightly slower than the fastest model, FNet, across all sequence lengths measured on GPUs. We also conduct systematic studies on the transfer learning capability of PoNet and observe that PoNet achieves 96.0% of the accuracy of BERT on the GLUE benchmark, outperforming FNet by 4.5% relative. Comprehensive ablation analysis demonstrates effectiveness of the designed multi-granularity pooling and pooling fusion for token mixing in long sequences and efficacy of the designed pre-training tasks for PoNet to learn transferable contextualized language representations.