While analysing rare blood cell aggregates remains challenging in automated h aematology, they could markedly advance label - free functional diagnostics. Conventional flow cytometers efficiently perform cell counting with leukocyte differentials but fail to identify aggregates with flagged results, requiring manual reviews. Quantitat ive phase imaging flow cytometry captures detailed aggregate morphologies, but clinical use is hampered by massive data storage and offline processing. Incorporating "hidden" biom arkers into routine haematology panels would significantly improve diagnostics with out flagged results. We present RT - HAD, a n end - to - end deep learning - based image and data processing framework for off - axis digital holographic microscopy (DHM), which combines physics - consistent holographic reconstruction and detection, represent ing each blood cell in a graph to recognize aggregates . RT - HAD processes >30 GB of image data on - the - fly with turnaround time of <1.5 min and error rate of 8.9% in platelet aggregate detection, which matches acceptable laboratory error rates of haematology biomarkers and solves the "big data" challenge for point - of - care diagnostics .

Human blood primarily comprises plasma, red blood cells, white blood cells, and platelets. It plays a vital role in transporting nutrients to different organs, where it stores essential health-related data about the human body. Blood cells are utilized to defend the body against diverse infections, including fungi, viruses, and bacteria. Hence, blood analysis can help physicians assess an individual's physiological condition. Blood cells have been sub-classified into eight groups: Neutrophils, eosinophils, basophils, lymphocytes, monocytes, immature granulocytes (promyelocytes, myelocytes, and metamyelocytes), erythroblasts, and platelets or thrombocytes on the basis of their nucleus, shape, and cytoplasm. Traditionally, pathologists and hematologists in laboratories have examined these blood cells using a microscope before manually classifying them. The manual approach is slower and more prone to human error. Therefore, it is essential to automate this process. In our paper, transfer learning with CNN pre-trained models. VGG16, VGG19, ResNet-50, ResNet-101, ResNet-152, InceptionV3, MobileNetV2, and DenseNet-20 applied to the PBC dataset's normal DIB. The overall accuracy achieved with these models lies between 91.375 and 94.72%. Hence, inspired by these pre-trained architectures, a model has been proposed to automatically classify the ten types of blood cells with increased accuracy. A novel CNN-based framework has been presented to improve accuracy. The proposed CNN model has been tested on the PBC dataset normal DIB. The outcomes of the experiments demonstrate that our CNN-based framework designed for blood cell classification attains an accuracy of 99.91% on the PBC dataset. Our proposed convolutional neural network model performs competitively when compared to earlier results reported in the literature.

As part of our SLAS Europe 2022 coverage, we speak to Professor Patricia Maguire from the University College Dublin about their AI_PREMie technology and how it can help to save mothers and babies lives. My name is Patricia Maguire, and I am a professor of biochemistry at University College, Dublin (UCD). Four years ago, I was appointed director of the UCD Institute for Discovery, a major university research institute in UCD, and our focus is cultivating interdisciplinary research. In that role, I first became excited by the possibilities of integrating AI into my research. I think there are two major obstacles to adopting AI in healthcare.

This article was published as a part of the Data Science Blogathon. You might be wandering in the vast domain of AI, and may have come across the word Exploratory Data Analysis, or EDA for short. Is it something important, if yes why? If you are looking for the answers to your question, you're in the right place. Also, I'll be showing a practical example of an EDA I did on my dataset recently, so stay tuned! Exploratory Data Analysis is the critical process of conducting initial investigations on data to discover patterns, spot anomalies, test hypotheses, and check assumptions with the help of summary statistics and graphical representations.

Cardio/cerebrovascular diseases (CVD) were the first cause of mortality worldwide in 2015, causing 31% of deaths according to World Health Organization [Organization, 2015]. Blood platelets play a key role in the occurrence of these cardio/cerebrovascular accidents in addition to complex process of blood coagulation, involving adhesion, aggregation and spreading on the vascular wall to stop a hemorrhage while avoiding the vessel occlusion. Although, in a recent biomedical evaluation study by Breet et al. [2010], the correlation between the clinical biological measures using platelet function tests and the occurrence of a cardiovascular event was found to be null for half of the techniques and rather modest for others, indicating the evident need for a more efficient tool or method to monitor patient platelet functionalities. This may be due to the fact that no current test allows the analysis of the different stages of platelet activation or the prediction of the in-vivo behavior of those platelets [Picker, 2011, Koltai et al., 2017]. In addition, the current clinical tests do not take into account the dynamic aspect of the process of platelet aggregation formation and the role that red blood cells can have in this process. To address these issues, Chopard et al. [2017b] provided a physical description of the adhesion and aggregation of platelets in the Impact-R device, by combining digital holography microscopy and mathematical modeling. They have developed a numerical model that quantitatively describes how platelets in a shear flow adhere and aggregate on a deposition surface. Further Dutta et al. [2018] showed how the five parameters of this model, specifying the deposition process and relevant for biomedical understanding of the phenomena, can be inferred from the blood sample collected from an individual using approximate Bayesian computation (ABC) [Lintusaari et al., 2017]. Our main claim here is that the values of some these parameters (eg.

Previous works on segmentation of SEM (scanning electron microscope) blood cell image ignore the semantic segmentation approach of whole-slide blood cell segmentation. In the proposed work, we address the problem of whole-slide blood cell segmentation using the semantic segmentation approach. We design a novel convolutional encoder-decoder framework along with VGG-16 as the pixel-level feature extraction model. -e proposed framework comprises 3 main steps: First, all the original images along with manually generated ground truth masks of each blood cell type are passed through the preprocessing stage. In the preprocessing stage, pixel-level labeling, RGB to grayscale conversion of masked image and pixel fusing, and unity mask generation are performed. After that, VGG16 is loaded into the system, which acts as a pretrained pixel-level feature extraction model. In the third step, the training process is initiated on the proposed model. We have evaluated our network performance on three evaluation metrics. We obtained outstanding results with respect to classwise, as well as global and mean accuracies. Our system achieved classwise accuracies of 97.45%, 93.34%, and 85.11% for RBCs, WBCs, and platelets, respectively, while global and mean accuracies remain 97.18% and 91.96%, respectively.

As more of our lives are reliant upon mobile electronics, there is an ever-growing risk of their delicate circuitry being damaged by knocks and bumps. But engineers have developed swarms of tiny autonomous molecular'robots' that can repair broken circuits that are too small for the human eye to see. The technology could help to extend the life of electronics, allowing expensive mobile phones, laptops and tablets to continue working for longer. The molecular'robots' are propelled along electronic circuits until they find an area that is damaged where they congregate to restore conductivity. The nanobots mimic the platelets found in blood, sensing a wound and aggregating at that spot to'heal' the damage.