Cardiologists often struggle to assess heart attack risk. New startups using AI could help. For all the modern marvels of cardiology, we struggle to predict who will have a heart attack. Many people never get screened at all. Now, startups like Bunkerhill Health, Nanox.AI, and HeartLung Technologies are applying AI algorithms to screen millions of CT scans for early signs of heart disease. This technology could be a breakthrough for public health, applying an old tool to uncover patients whose high risk for a heart attack is hiding in plain sight.

--Dermatological care via telemedicine often lacks the rich context of in-person visits. Clinicians must make diagnoses based on a handful of images and brief descriptions, without the benefit of physical exams, second opinions, or reference materials. While many medical AI systems attempt to bridge these gaps with domain-specific fine-tuning, this work hypothesized that mimicking clinical reasoning processes could offer a more effective path forward. This study tested seven vision-language models on medical visual question answering across six configurations: baseline models, fine-tuned variants, and both augmented with either reasoning layers that combine multiple model perspectives, analogous to peer consultation, or retrieval-augmented generation that incorporates medical literature at inference time, serving a role similar to reference-checking. While fine-tuning degraded performance in four of seven models with an average 30% decrease, baseline models collapsed on test data. Clinical-inspired architectures, meanwhile, achieved up to 70% accuracy, maintaining performance on unseen data while generating explainable, literature-grounded outputs critical for clinical adoption. These findings demonstrate that medical AI succeeds by reconstructing the collaborative and evidence-based practices fundamental to clinical diagnosis. Fine-tuning large models on medical data, the standard approach to medical AI, assumes domain exposure produces clinical competence [1]. Y et dermatology models show 15% performance drops in real-world settings [2], and catastrophic forgetting causes models to generate outputs exclusively from their training data [3]. This brittleness suggests a fundamental mismatch between current approaches and clinical reasoning. Additionally, physician groups achieve 85.6% diagnostic accuracy versus 62.5% for individuals [4], as collaboration reduces cognitive load and bias [5]. However, logistical constraints force physicians to work alone, a problem telemedicine intensifies by eliminating physical exams, peer consultation, and immediate reference access [6].

Quantifying the distribution and morphology of tau protein structures in brain tissues is key to diagnosing Alzheimer's Disease (AD) and its subtypes. Recently, deep learning (DL) models such as UNet have been successfully used for automatic segmentation of histopathological whole slide images (WSI) of biological tissues. In this study, we propose a DL-based methodology for semantic segmentation of tau lesions (i.e., neuritic plaques) in WSI of postmortem patients with AD. The state of the art in semantic segmentation of neuritic plaques in human WSI is very limited. Our study proposes a baseline able to generate a significant advantage for morphological analysis of these tauopathies for further stratification of AD patients. Essential discussions concerning biomarkers (ALZ50 versus AT8 tau antibodies), the imaging modality (different slide scanner resolutions), and the challenge of weak annotations are addressed within this seminal study. The analysis of the impact of context in plaque segmentation is important to understand the role of the micro-environment for reliable tau protein segmentation. In addition, by integrating visual interpretability, we are able to explain how the network focuses on a region of interest (ROI), giving additional insights to pathologists.

Stranded dolphins have been discovered with brain changes associated with Alzheimer's disease in humans. Researchers from the University of Glasgow studied the brains of 22 odontocetes - toothed whales - thathad died in coastal waters off Scotland. One bottlenose dolphin, one white-beaked dolphin and two long-finned pilot whales had accumulated amyloid-beta plaques, which is a hallmark of dementia. The researchers say these ill creatures could have led their otherwise healthy group, or pod, into shallow waters by mistake after getting confused or lost. Whales, dolphins and porpoises are regularly found stranded in shallow waters or beaches around the UK coastline, and often in pods.

Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap thickness, which provides an opportunity to assess plaque vulnerability. We developed an automated method that can detect lipidous plaque and assess fibrous cap thickness in IVOCT images. This study analyzed a total of 4,360 IVOCT image frames of 77 lesions among 41 patients. To improve segmentation performance, preprocessing included lumen segmentation, pixel-shifting, and noise filtering on the raw polar (r, theta) IVOCT images. We used the DeepLab-v3 plus deep learning model to classify lipidous plaque pixels. After lipid detection, we automatically detected the outer border of the fibrous cap using a special dynamic programming algorithm and assessed the cap thickness. Our method provided excellent discriminability of lipid plaque with a sensitivity of 85.8% and A-line Dice coefficient of 0.837. By comparing lipid angle measurements between two analysts following editing of our automated software, we found good agreement by Bland-Altman analysis (difference 6.7+/-17 degree; mean 196 degree). Our method accurately detected the fibrous cap from the detected lipid plaque. Automated analysis required a significant modification for only 5.5% frames. Furthermore, our method showed a good agreement of fibrous cap thickness between two analysts with Bland-Altman analysis (4.2+/-14.6 micron; mean 175 micron), indicating little bias between users and good reproducibility of the measurement. We developed a fully automated method for fibrous cap quantification in IVOCT images, resulting in good agreement with determinations by analysts. The method has great potential to enable highly automated, repeatable, and comprehensive evaluations of TCFAs.

Segmenting dental plaque from images of medical reagent staining provides valuable information for diagnosis and the determination of follow-up treatment plan. However, accurate dental plaque segmentation is a challenging task that requires identifying teeth and dental plaque subjected to semantic-blur regions (i.e., confused boundaries in border regions between teeth and dental plaque) and complex variations of instance shapes, which are not fully addressed by existing methods. Therefore, we propose a semantic decomposition network (SDNet) that introduces two single-task branches to separately address the segmentation of teeth and dental plaque and designs additional constraints to learn category-specific features for each branch, thus facilitating the semantic decomposition and improving the performance of dental plaque segmentation. Specifically, SDNet learns two separate segmentation branches for teeth and dental plaque in a divide-and-conquer manner to decouple the entangled relation between them. Each branch that specifies a category tends to yield accurate segmentation. To help these two branches better focus on category-specific features, two constraint modules are further proposed: 1) contrastive constraint module (CCM) to learn discriminative feature representations by maximizing the distance between different category representations, so as to reduce the negative impact of semantic-blur regions on feature extraction; 2) structural constraint module (SCM) to provide complete structural information for dental plaque of various shapes by the supervision of an boundary-aware geometric constraint. Besides, we construct a large-scale open-source Stained Dental Plaque Segmentation dataset (SDPSeg), which provides high-quality annotations for teeth and dental plaque. Experimental results on SDPSeg datasets show SDNet achieves state-of-the-art performance.

We have long known that smoking, high cholesterol, diabetes and hypertension are risk factors for heart disease, but many people develop a silent build-up of plaque in their arteries and suffer subsequent heart attack without any of these risk factors,

The generous gift supports collaborative, multi-disciplinary research underway in the University of Sydney's Digital Sciences Initiative. The founders of global tech company Appen, Julia and Chris Vonwiller, will fund a $1 million acceleration of the University's Digital Sciences Initiative (DSI). The gift will support renowned researcher Professor Gemma Figtree's collaboration with the DSI in her quest to achieve the'holy grail' of cardiac disease research – the discovery of blood-based biomarkers that indicate the earliest signs of heart disease. Coronary heart disease is the leading cause of death worldwide, killing an estimated 7.2 million people each year. In Australia, it is also the leading cause of disease burden as well as death, affecting more than 580,000 people in 2017-18.

In this interview, we speak to Dr. Damini Dey from Cedars-Sinai Health System about their latest research that involved using artificial intelligence to predict heart attacks. My name is Dr. Damini Dey. I am a scientist and professor working with quantitative cardiovascular imaging at Cedars-Sinai Health System in Los Angeles. We have been working with artificial intelligence (AI) to improve the prediction of cardiovascular events, such as heart attacks, and efficient and automated measurement of imaging biomarkers. We have been working on this task for a number of years.

What if you could predict a heart attack? Los Angeles' Cedars-Sinai Medical Center announced this week the development of a tool that uses artificial intelligence to measure artery health and detect future cardiac risks in seemingly healthy patients as far as five years in advance. Heart attacks are often caused by plaque deposits in arteries, the muscular-walled tubes that carry oxygenated blood throughout the body. These deposits constrict blood flow and raise the risk of potential heart problems. While doctors can use CTA scans to create 3D images of a patient's arteries and measure the density and composition of such plaque, it can be a complicated and time-consuming process.