Many decision in clinical science and epidemiology -- estimating probability of technical success for a clinical trial, assessing comparative effectiveness of two therapies, imputing a placebo effect onto natural history data -- rely on combining sources of information about a clinical cohort that comes from different kinds of studies. Specifically we contrast patient-level sources that provide granular pictures of individual disease course (clinical trial, registries, or electronic health records) with aggregate sources such as published clinical trial results and the TFLs (tables figures and listings). One strategy for combining aggregate with patient-level data sources is to bring each into a common format for a unified analysis. If one wants to maintain the analytic flexibility of patient-level data, then a natural solution is to convert the aggregate data information into a simulated patient-level dataset that recapitulate those aggregate statistics. This is an under-determined inverse problem in that there are many such datasets, and it cannot be well specified without further constraints. FRESH(Fusion of Recent Evidence with Subject Histories) provides a well-defined method for solving this problem, and therefore providing maximal analytic flexibility.

In order to accurately identify the performance status of mobile devices and finely adjust the user experience, a real-time performance perception evaluation method based on TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) combined with entropy weighting method and time series model construction was studied. After collecting the performance characteristics of various mobile devices, the device performance profile was fitted by using PCA (principal component analysis) dimensionality reduction and feature engineering methods such as descriptive time series analysis. The ability of performance features and profiles to describe the real-time performance status of devices was understood and studied by applying the TOPSIS method and multi-level weighting processing. A time series model was constructed for the feature set under objective weighting, and multiple sensitivity (real-time, short-term, long-term) performance status perception results were provided to obtain real-time performance evaluation data and long-term stable performance prediction data. Finally, by configuring dynamic AB experiments and overlaying fine-grained power reduction strategies, the usability of the method was verified, and the accuracy of device performance status identification and prediction was compared with the performance of the profile features including dimensionality reduction time series modeling, TOPSIS method and entropy weighting method, subjective weighting, HMA method. The results show that accurate real-time performance perception results can greatly enhance business value, and this research has application effectiveness and certain forward-looking significance.