Deep learning-based myocardial scar segmentation from late gadolinium enhancement (LGE) cardiac MRI has shown great potential for accurate and timely diagnosis and treatment planning for structural cardiac diseases. However, the limited availability and variability of LGE images with high-quality scar labels restrict the development of robust segmentation models. To address this, we introduce CLAIM: \textbf{C}linically-Guided \textbf{L}GE \textbf{A}ugmentation for Real\textbf{i}stic and Diverse \textbf{M}yocardial Scar Synthesis and Segmentation framework, a framework for anatomically grounded scar generation and segmentation. At its core is the SMILE module (Scar Mask generation guided by cLinical knowledgE), which conditions a diffusion-based generator on the clinically adopted AHA 17-segment model to synthesize images with anatomically consistent and spatially diverse scar patterns. In addition, CLAIM employs a joint training strategy in which the scar segmentation network is optimized alongside the generator, aiming to enhance both the realism of synthesized scars and the accuracy of the scar segmentation performance. Experimental results show that CLAIM produces anatomically coherent scar patterns and achieves higher Dice similarity with real scar distributions compared to baseline models. Our approach enables controllable and realistic myocardial scar synthesis and has demonstrated utility for downstream medical imaging task. Code is available at https://github.com/farheenjabeen/CLAIM-Scar-Synthesis.

Over the years, ComBAT has become the standard method for harmonizing MRI-derived measurements, with its ability to compensate for site-related additive and multiplicative biases while preserving biological variability. However, ComBAT relies on a set of assumptions that, when violated, can result in flawed harmonization. In this paper, we thoroughly review ComBAT's mathematical foundation, outlining these assumptions, and exploring their implications for the demographic composition necessary for optimal results. Through a series of experiments involving a slightly modified version of ComBAT called Pairwise-ComBAT tailored for normative modeling applications, we assess the impact of various population characteristics, including population size, age distribution, the absence of certain covariates, and the magnitude of additive and multiplicative factors. Based on these experiments, we present five essential recommendations that should be carefully considered to enhance consistency and supporting reproducibility, two essential factors for open science, collaborative research, and real-life clinical deployment.

The effect of error correction oftenappears in ensembles of neural networks: it is known that, in most cases, an ensemble can improve the effectiveness of the base network [2]. The creation of an ensemble of models is widely used in modern machine learning as the last step of the working pipeline. However, it is difficult to predict which mistakes the ensemble can eliminate from the basic model and which can not. This problem of possible mistakes of the trained model remains relevant because the representation of the data learned by the neural network is difficult to interpret [3]. The reliability of a neural network is directly connected to the quality of the internal data representation that it has built.

In this article we focus on detecting hypoxia (or oxygen deprivation), a very serious condition that can arise from different pathologies and can lead to lifelong disability and death. We present a novel approach to hypoxia detection based on recordings of the uterine pressure and fetal heart rate, which are obtained using standard labor monitoring devices. The key idea is to learn models of the fetal response to signals from its environment. Then, we use the parameters of these models as attributes in a binary classification problem. A running count of pathological classifications over several time periods is taken to provide the current label for the fetus.

Labor monitoring is crucial in modern health care, as it can be used to detect (and help avoid) significant problems with the fetus. In this article we focus on detecting hypoxia (or oxygen deprivation), a very serious condition that can arise from different pathologies and can lead to life-long disability and death. We present a novel approach to hypoxia detection based on recordings of the uterine pressure and fetal heart rate, which are obtained using standard labor monitoring devices. Then, we use the parameters of these models as attributes in a binary classification problem.

Labor monitoring is crucial in modern health care, as it can be used to detect (and help avoid) significant problems with the fetus. In this article we focus on detecting hypoxia (or oxygen deprivation), a very serious condition that can arise from different pathologies and can lead to life-long disability and death. We present a novel approach to hypoxia detection based on recordings of the uterine pressure and fetal heart rate, which are obtained using standard labor monitoring devices. The key idea is to learn models of the fetal response to signals from its environment. Then, we use the parameters of these models as attributes in a binary classification problem. A running count of pathological classifications over several time periods is taken to provide the current label for the fetus. We use a unique database of real clinical recordings, both from normal and pathological cases. Our approach classifies correctly more than half the pathological cases, 1.5 hours before delivery. These are cases that were missed by clinicians; early detection of this type would have allowed the physician to perform a Caesarean section, possibly avoiding the negative outcome.

Labor monitoring is crucial in modern health care, as it can be used to detect (and help avoid) significant problems with the fetus. In this paper we focus on hypoxia (or oxygen deprivation), a very serious condition that can arise from different pathologies and can lead to life-long disability and death. We present a novel approach to hypoxia detection based on recordings of the uterine pressure and fetal heart rate, which are routinely monitored during labor. The key idea is to learn models of the fetal response to signals from its environment, using time series data recorded during labor. Then, we use the parameters of these models as attributes in a binary classification problem. A majority vote over several periods is taken to provide the current label for the fetus. We use a unique database of real clinical recordings, both from normal and pathological cases. Our approach classifies correctly more than half the pathological cases, 1.5 hours before delivery. These are cases that were missed by clinicians; early detection of this type would have allowed the physician to perform a Caesarean section, possibly avoiding the negative outcome