Breakthroughs, discoveries, and DIY tips sent every weekday. It's a really big deal when fossilized feces survive the ravages of time. These hardened pieces of excrement open up a window into what animals ate thousands of years ago and even what may have made them sick . Humans are not exempt from this, with dried human feces indicating we have always loved cheese and beer and that our microbiome has evolved over thousands of years. DNA recovered from 1,000-year-old dried feces indicates that intestinal infections from pinworm or Shingella may have plagued ancient people living in present day northern Mexico's Rio Zape Valley.

Environment Animals Wildlife Bats Why do bats spread so many diseases? Survival of the fittest doesn't always mean smartest, fastest, or strongest. Breakthroughs, discoveries, and DIY tips sent every weekday. There are way more bats than you might think. Second only to rodents, bats make up around a fifth of all mammals, with over 1,500 species of winged nightflyers .

Antimicrobial resistance (AMR) is projected to cause up to 10 million deaths annually by 2050, underscoring the urgent need for new antibiotics. Here we present ApexAmphion, a deep-learning framework for de novo design of antibiotics that couples a 6.4-billion-parameter protein language model with reinforcement learning. The model is first fine-tuned on curated peptide data to capture antimicrobial sequence regularities, then optimised with proximal policy optimization against a composite reward that combines predictions from a learned minimum inhibitory concentration (MIC) classifier with differentiable physicochemical objectives. In vitro evaluation of 100 designed peptides showed low MIC values (nanomolar range in some cases) for all candidates (100% hit rate). Moreover, 99 our of 100 compounds exhibited broad-spectrum antimicrobial activity against at least two clinically relevant bacteria. The lead molecules killed bacteria primarily by potently targeting the cytoplasmic membrane. By unifying generation, scoring and multi-objective optimization with deep reinforcement learning in a single pipeline, our approach rapidly produces diverse, potent candidates, offering a scalable route to peptide antibiotics and a platform for iterative steering toward potency and developability within hours.

Antimicrobial resistance (AMR) is escalating and outpacing current antibiotic development. Thus, discovering antibiotics effective against emerging pathogens is becoming increasingly critical. However, existing approaches cannot rapidly identify effective molecules against novel pathogens or emerging drug-resistant strains. Here, we introduce ApexOracle, an artificial intelligence (AI) model that both predicts the antibacterial potency of existing compounds and designs de novo molecules active against strains it has never encountered. Departing from models that rely solely on molecular features, ApexOracle incorporates pathogen-specific context through the integration of molecular features captured via a foundational discrete diffusion language model and a dual-embedding framework that combines genomic- and literature-derived strain representations. Across diverse bacterial species and chemical modalities, ApexOracle consistently outperformed state-of-the-art approaches in activity prediction and demonstrated reliable transferability to novel pathogens with little or no antimicrobial data. Its unified representation-generation architecture further enables the in silico creation of "new-to-nature" molecules with high predicted efficacy against priority threats. By pairing rapid activity prediction with targeted molecular generation, ApexOracle offers a scalable strategy for countering AMR and preparing for future infectious-disease outbreaks.

Fox News senior national correspondent Rich Edson has the latest on a Chinese pair charged with smuggling a'devastating' pathogen to the U.S. on'The Story.' By all appearances, the world is edging perilously close to the brink of a catastrophic global conflict. In just the past few days, five deeply troubling developments have emerged -- each significant on its own -- but taken together, they form a pattern too urgent to dismiss. Viewed in context, these events expose a rapidly deteriorating international order, where diplomacy is failing, deterrence is weakening, and the risk of multi-theater war is rising sharply. First, Ukraine's audacious drone strike deep inside Russian territory -- reportedly destroying or damaging a significant share of Russia's strategic bomber fleet -- bears the hallmarks of Western involvement.

Anyone who has tried to keep porch plants or a home garden alive through seasonal changes knows it's a task easier said than done. Abrupt temperature changes--like cold snaps--and prolonged periods of drought can stress plants, disrupting their normal biochemistry. If not addressed quickly enough, those stresses can eventually kill the plant. Disappointed growers often only see the tell-tale signs (like shriveling or browning leaves) after it's too late. But a new plant-wearable device developed by researchers at the American Chemical Society could offer an early warning system. The wearable, detailed this week in the journal ACS Sensors, comes in the form of an electromagnetic sensor attached directly to plant leaves.

Foodborne gastrointestinal (GI) illness is a common cause of ill health in the UK. However, many cases do not interact with the healthcare system, posing significant challenges for traditional surveillance methods. The growth of publicly available online restaurant reviews and advancements in large language models (LLMs) present potential opportunities to extend disease surveillance by identifying public reports of GI illness. In this study, we introduce a novel annotation schema, developed with experts in GI illness, applied to the Yelp Open Dataset of reviews. Our annotations extend beyond binary disease detection, to include detailed extraction of information on symptoms and foods. We evaluate the performance of open-weight LLMs across these three tasks: GI illness detection, symptom extraction, and food extraction. We compare this performance to RoBERTa-based classification models fine-tuned specifically for these tasks. Our results show that using prompt-based approaches, LLMs achieve micro-F1 scores of over 90% for all three of our tasks. Using prompting alone, we achieve micro-F1 scores that exceed those of smaller fine-tuned models. We further demonstrate the robustness of LLMs in GI illness detection across three bias-focused experiments. Our results suggest that publicly available review text and LLMs offer substantial potential for public health surveillance of GI illness by enabling highly effective extraction of key information. While LLMs appear to exhibit minimal bias in processing, the inherent limitations of restaurant review data highlight the need for cautious interpretation of results.

Antibiotic Resistance (AR) is a critical global health challenge that necessitates the development of cost-effective, efficient, and accurate diagnostic tools. Given the genetic basis of AR, techniques such as Polymerase Chain Reaction (PCR) that target specific resistance genes offer a promising approach for predictive diagnostics using a limited set of key genes. This study introduces GenoARM, a novel framework that integrates reinforcement learning (RL) with transformer-based models to optimize the selection of PCR gene tests and improve AR predictions, leveraging observed metadata for improved accuracy. In our evaluation, we developed several high-performing baselines and compared them using publicly available datasets derived from real-world bacterial samples representing multiple clinically relevant pathogens. The results show that all evaluated methods achieve strong and reliable performance when metadata is not utilized. When metadata is introduced and the number of selected genes increases, GenoARM demonstrates superior performance due to its capacity to approximate rewards for unseen and sparse combinations. Overall, our framework represents a major advancement in optimizing diagnostic tools for AR in clinical settings.

Host-response-based diagnostics can improve the accuracy of diagnosing bacterial and viral infections, thereby reducing inappropriate antibiotic prescriptions. However, the existing cohorts with limited sample size and coarse infections types are unable to support the exploration of an accurate and generalizable diagnostic model. Here, we curate the largest infection host-response transcriptome data, including 11,247 samples across 89 blood transcriptome datasets from 13 countries and 21 platforms. We build a diagnostic model for pathogen prediction starting from a pan-infection model as foundation (AUC = 0.97) based on the pan-infection dataset. Then, we utilize knowledge distillation to efficiently transfer the insights from this "teacher" model to four lightweight pathogen "student" models, i.e., staphylococcal infection (AUC = 0.99), streptococcal infection (AUC = 0.94), HIV infection (AUC = 0.93), and RSV infection (AUC = 0.94), as well as a sepsis "student" model (AUC = 0.99). The proposed knowledge distillation framework not only facilitates the diagnosis of pathogens using pan-infection data, but also enables an across-disease study from pan-infection to sepsis. Moreover, the framework enables high-degree lightweight design of diagnostic models, which is expected to be adaptively deployed in clinical settings.

As a result of rapidly accelerating AI capabilities, over the past year, national governments and multinational bodies have announced efforts to address safety, security and ethics issues related to AI models. One high priority among these efforts is the mitigation of misuse of AI models. Many biologists have for decades sought to reduce the risks of scientific research that could lead, through accident or misuse, to high-consequence disease outbreaks. Scientists have carefully considered what types of life sciences research have the potential for both benefit and risk (dual-use), especially as scientific advances have accelerated our ability to engineer organisms and create novel variants of pathogens. Here we describe how previous experience and study by scientists and policy professionals of dual-use capabilities in the life sciences can inform risk evaluations of AI models with biological capabilities. We argue that AI model evaluations should prioritize addressing high-consequence risks (those that could cause large-scale harm to the public, such as pandemics), and that these risks should be evaluated prior to model deployment so as to allow potential biosafety and/or biosecurity measures. Scientists' experience with identifying and mitigating dual-use biological risks can help inform new approaches to evaluating biological AI models. Identifying which AI capabilities post the greatest biosecurity and biosafety concerns is necessary in order to establish targeted AI safety evaluation methods, secure these tools against accident and misuse, and avoid impeding immense potential benefits.