We include all our annotations and extracted landmarks. This ensures that we uphold the highest standards of ethical data usage. In Table A1, we summarize the severity label distribution in Y ouTubePD. We also summarize the demographic distribution in Y ouTubePD, split between PD-positive and healthy control (HC), or PD-negative, subjects. This decision is based on the clinician's suggestion, since an accurate UPDRS facial expression rating would require more This strategy also allows for a finer classification.

The healthcare and AI communities have witnessed a growing interest in the development of AI-assisted systems for automated diagnosis of Parkinson's Disease

Predicting Parkinson's Disease (PD) progression is crucial, and voice biomarkers offer a non-invasive method for tracking symptom severity (UPDRS scores) through telemonitoring. Analyzing this longitudinal data is challenging due to within-subject correlations and complex, nonlinear patient-specific progression patterns. This study benchmarks LMMs against two advanced hybrid approaches: the Generalized Neural Network Mixed Model (GNMM) (Mandel 2021), which embeds a neural network within a GLMM structure, and the Neural Mixed Effects (NME) model (Wortwein 2023), allowing nonlinear subject-specific parameters throughout the network. Using the Oxford Parkinson's telemonitoring voice dataset, we evaluate these models' performance in predicting Total UPDRS to offer practical guidance for PD research and clinical applications.

The healthcare and AI communities have witnessed a growing interest in the development of AI-assisted systems for automated diagnosis of Parkinson's Disease (PD), one of the most prevalent neurodegenerative disorders. However, the progress in this area has been significantly impeded by the absence of a unified, publicly available benchmark, which prevents comprehensive evaluation of existing PD analysis methods and the development of advanced models. This work overcomes these challenges by introducing YouTubePD -- the first publicly available multimodal benchmark designed for PD analysis. We crowd-source existing videos featured with PD from YouTube, exploit multimodal information including in-the-wild videos, audio data, and facial landmarks across 200+ subject videos, and provide dense and diverse annotations from clinical expert. Based on our benchmark, we propose three challenging and complementary tasks encompassing both discriminative and generative tasks, along with a comprehensive set of corresponding baselines. Experimental evaluation showcases the potential of modern deep learning and computer vision techniques, in particular the generalizability of the models developed on YouTubePD to real-world clinical settings, while revealing their limitations. We hope our work paves the way for future research in this direction.

We introduce a unified benchmarking framework focused on evaluating EEG-based foundation models in clinical applications. The benchmark spans 11 well-defined diagnostic tasks across 14 publicly available EEG datasets, including epilepsy, schizophrenia, Parkinson's disease, OCD, and mild traumatic brain injury. It features minimal preprocessing, standardized evaluation protocols, and enables side-by-side comparisons of classical baselines and modern foundation models. Our results show that while foundation models achieve strong performance in certain settings, simpler models often remain competitive, particularly under clinical distribution shifts. To facilitate reproducibility and adoption, we release all prepared data and code in an accessible and extensible format.

AI-assisted gait analysis holds promise for improving Parkinson's Disease (PD) care, but current clinical dashboards lack transparency and offer no meaningful way for clinicians to interrogate or contest AI decisions. To address this issue, we present Motion2Meaning, a clinician-centered framework that advances Contestable AI through a tightly integrated interface designed for interpretability, oversight, and procedural recourse. Our approach leverages vertical Ground Reaction Force (vGRF) time-series data from wearable sensors as an objective biomarker of PD motor states. The system comprises three key components: a Gait Data Visualization Interface (GDVI), a one-dimensional Convolutional Neural Network (1D-CNN) that predicts Hoehn & Yahr severity stages, and a Contestable Interpretation Interface (CII) that combines our novel Cross-Modal Explanation Discrepancy (XMED) safeguard with a contestable Large Language Model (LLM). Our 1D-CNN achieves 89.0% F1-score on the public PhysioNet gait dataset. XMED successfully identifies model unreliability by detecting a five-fold increase in explanation discrepancies in incorrect predictions (7.45%) compared to correct ones (1.56%), while our LLM-powered interface enables clinicians to validate correct predictions and successfully contest a portion of the model's errors. A human-centered evaluation of this contestable interface reveals a crucial trade-off between the LLM's factual grounding and its readability and responsiveness to clinical feedback. This work demonstrates the feasibility of combining wearable sensor analysis with Explainable AI (XAI) and contestable LLMs to create a transparent, auditable system for PD gait interpretation that maintains clinical oversight while leveraging advanced AI capabilities. Our implementation is publicly available at: https://github.com/hungdothanh/motion2meaning.

Scientists Thought Parkinson's Was in Our Genes. New ideas about chronic illness could revolutionize treatment, if we take the research seriously. Amy Lindberg spent 26 years in the Navy and she still walked like it--with intention, like her chin had someplace to be. But around 2017, her right foot stopped following orders. Lindberg and her husband Brad were five years into their retirement. After moving 10 times for Uncle Sam, they'd bought their dream house near the North Carolina coast. They had a backyard that spilled out onto wetlands. From the kitchen, you could see cranes hunting. They kept bees and played pickleball and watched their children grow. But now Lindberg's right foot was out of rhythm. She worked hard to ignore it, but she couldn't disregard the tremors.

Accurate and interpretable gait analysis plays a crucial role in the early detection of Parkinsons disease (PD),yet most existing approaches remain limited by single-modality inputs, low robustness, and a lack of clinical transparency. This paper presents an explainable multimodal framework that integrates RGB and Depth (RGB-D) data to recognize Parkinsonian gait patterns under realistic conditions. The proposed system employs dual YOLOv11-based encoders for modality-specific feature extraction, followed by a Multi-Scale Local-Global Extraction (MLGE) module and a Cross-Spatial Neck Fusion mechanism to enhance spatial-temporal representation. This design captures both fine-grained limb motion (e.g., reduced arm swing) and overall gait dynamics (e.g., short stride or turning difficulty), even in challenging scenarios such as low lighting or occlusion caused by clothing. To ensure interpretability, a frozen Large Language Model (LLM) is incorporated to translate fused visual embeddings and structured metadata into clinically meaningful textual explanations. Experimental evaluations on multimodal gait datasets demonstrate that the proposed RGB-D fusion framework achieves higher recognition accuracy, improved robustness to environmental variations, and clear visual-linguistic reasoning compared with single-input baselines. By combining multimodal feature learning with language-based interpretability, this study bridges the gap between visual recognition and clinical understanding, offering a novel vision-language paradigm for reliable and explainable Parkinsons disease gait analysis. Code:https://github.com/manaralnaasan/RGB-D_parkinson-LLM

Background: Impairment of visual spatial cognitive function is the most common early clinical manifestation of Alzheimer's Disease (AD). When the Montreal Cognitive Assessment (MoCA) uses the "0/1" binary method ("pass/fail") to evaluate the visual spatial cognitive ability represented by the Cube Copying Test(CCT), the elder with less formal education generally score 0 point, resulting in serious bias in the evaluation results. Therefore, this study proposes a fine evaluation method for CCT based on dynamic handwriting feature extraction of DH-SCSM-BLA. method : The Cogni-CareV3.0 software independently developed by our team was used to collect dynamic handwriting data of CCT. Then, the spatial and motion features of segmented dynamic handwriting were extracted, and feature matrix with unequal dimensions were normalized. Finally, a bidirectional long short-term memory network model combined with attention mechanism (BiLSTM-Attention) was adopted for classification. Result: The experimental results showed that: The proposed method has significant superiority compared to similar studies, with a classification accuracy of 86.69%. The distribution of cube drawing ability scores has significant regularity for three aspects such as MCI patients and healthy control group, age, and levels of education. It was also found that score for each cognitive task including cube drawing ability score is negatively correlated with age. Score for each cognitive task including cube drawing ability score, but positively correlated with levels of education significantly. Conclusion: This study provides a relatively objective and comprehensive evaluation method for early screening and personalized intervention of visual spatial cognitive impairment.