Low-Rank Adaptation (LoRA) is one of the most widely used techniques for fine-tuning large language models (LLMs). By introducing a small number of trainable low-rank weight matrices, LoRA substantially reduces the number of parameters that need to be updated, offering significant advantages in memory consumption and computational efficiency compared to full fine-tuning. However, we observed that LoRA does not consistently provide speed improvements across all model architectures and training setups. Motivated by this inconsistency, we conduct a comprehensive analysis of LoRA's performance and investigate the underlying factors limiting its speedup. Based on our findings, we propose several methods for more efficient fine-tuning of LLMs. We empirically evaluate these methods and compare them to LoRA, demonstrating that our approach achieves comparable or superior performance while delivering more consistent training speed improvements. Our work offers valuable insights and practical guidelines for practitioners seeking to optimize LLM fine-tuning under resource constraints.

Prior parameter-efficient fine-tuning (PEFT) algorithms reduce memory usage and computational costs of fine-tuning large neural network models by training only a few additional adapter parameters, rather than the entire model. However, the reduction in computational costs due to PEFT does not necessarily translate to a reduction in training time; although the computational costs of the adapter layers are much smaller than the pretrained layers, it is well known that those two types of layers are processed sequentially on GPUs, resulting in significant latency overhead. LoRA and its variants merge low-rank adapter matrices with pretrained weights during inference to avoid latency overhead, but during training, the pretrained weights remain frozen while the adapter matrices are continuously updated, preventing such merging. To mitigate this issue, we propose Partial Connection Adaptation (PaCA), which fine-tunes randomly selected partial connections within the pretrained weights instead of introducing adapter layers in the model. PaCA not only enhances training speed by eliminating the time overhead due to the sequential processing of the adapter and pretrained layers but also reduces activation memory since only partial activations, rather than full activations, need to be stored for gradient computation. Compared to LoRA, PaCA reduces training time by 22% and total memory usage by 16%, while maintaining comparable accuracy across various fine-tuning scenarios, such as fine-tuning on the MMLU dataset and instruction tuning on the Oasst1 dataset. PaCA can also be combined with quantization, enabling the fine-tuning of large models such as LLaMA3.1-70B. In addition, PaCA enables training with 23% longer sequence and improves throughput by 16% on both NVIDIA A100 GPU and INTEL Gaudi2 HPU compared to LoRA. The code is available at https://github.com/WooSunghyeon/paca.

Background: Recently, numerous foundation models pretrained on extensive data have demonstrated efficacy in disease prediction using Electronic Health Records (EHRs). However, there remains some unanswered questions on how to best utilize such models especially with very small fine-tuning cohorts. Methods: We utilized Med-BERT, an EHR-specific foundation model, and reformulated the disease binary prediction task into a token prediction task and a next visit mask token prediction task to align with Med-BERT's pretraining task format in order to improve the accuracy of pancreatic cancer (PaCa) prediction in both few-shot and fully supervised settings. Results: The reformulation of the task into a token prediction task, referred to as Med-BERT-Sum, demonstrates slightly superior performance in both few-shot scenarios and larger data samples. Furthermore, reformulating the prediction task as a Next Visit Mask Token Prediction task (Med-BERT-Mask) significantly outperforms the conventional Binary Classification (BC) prediction task (Med-BERT-BC) by 3% to 7% in few-shot scenarios with data sizes ranging from 10 to 500 samples. These findings highlight that aligning the downstream task with Med-BERT's pretraining objectives substantially enhances the model's predictive capabilities, thereby improving its effectiveness in predicting both rare and common diseases. Conclusion: Reformatting disease prediction tasks to align with the pretraining of foundation models enhances prediction accuracy, leading to earlier detection and timely intervention. This approach improves treatment effectiveness, survival rates, and overall patient outcomes for PaCa and potentially other cancers.

Recent advances in large language models (LLMs) have accelerated the development of conversational agents capable of generating human-like responses. Since psychiatric assessments typically involve complex conversational interactions between psychiatrists and patients, there is growing interest in developing LLM-based psychiatric assessment conversational agents (PACAs) that aim to simulate the role of psychiatrists in clinical evaluations. However, standardized methods for benchmarking the clinical appropriateness of PACAs' interaction with patients still remain underexplored. Here, we propose PSYCHE, a novel framework designed to enable the 1) clinically relevant, 2) ethically safe, 3) cost-efficient, and 4) quantitative evaluation of PACAs. This is achieved by simulating psychiatric patients based on a multi-faceted psychiatric construct that defines the simulated patients' profiles, histories, and behaviors, which PACAs are expected to assess. We validate the effectiveness of PSYCHE through a study with 10 board-certified psychiatrists, supported by an in-depth analysis of the simulated patient utterances.

Scene rearrangement, like table tidying, is a challenging task in robotic manipulation due to the complexity of predicting diverse object arrangements. Web-scale trained generative models such as Stable Diffusion can aid by generating natural scenes as goals. To facilitate robot execution, object-level representations must be extracted to match the real scenes with the generated goals and to calculate object pose transformations. Current methods typically use a multi-step design that involves separate models for generation, segmentation, and feature encoding, which can lead to a low success rate due to error accumulation. Furthermore, they lack control over the viewing perspectives of the generated goals, restricting the tasks to 3-DoF settings. In this paper, we propose PACA, a zero-shot pipeline for scene rearrangement that leverages perspective-aware cross-attention representation derived from Stable Diffusion. Specifically, we develop a representation that integrates generation, segmentation, and feature encoding into a single step to produce object-level representations. Additionally, we introduce perspective control, thus enabling the matching of 6-DoF camera views and extending past approaches that were limited to 3-DoF top-down views. The efficacy of our method is demonstrated through its zero-shot performance in real robot experiments across various scenes, achieving an average matching accuracy and execution success rate of 87% and 67%, respectively.