Can Tech Get Rid of Bad Trips? In this episode of, we talk about some of the latest drug trends and all the ways drugs are changing as they continue to be intertwined with tech. Whether it's teenagers reviving the Benadryl TikTok challenge or people signing up for an out-of-body experience program previously used by the CIA, some of us are chasing unconventional trips--bad trips, essentially. But these trends are happening at a time when AI companies are also looking to create a "cleaner" trip for users, and others are using AI chatbots to therapeutically guide their psychedelic trips. Host Michael Calore sits down with staff writer Boone Ashworth and senior editor Manisha Krishnan to discuss these trends--and the promises and limitations of relying on tech to avoid bad trips. Young People Are Tripping on Benadryl--and It's Always a Bad Time The CIA Used This Psychic Meditation Program. It's Never Been More Popular Please help us improve by filling out our listener survey . Write to us at uncannyvalley@wired.com . You can always listen to this week's podcast through the audio player on this page, but if you want to subscribe for free to get every episode, here's how: If you're on an iPhone or iPad, open the app called Podcasts, or just tap this link . Hey, Mike, how are you? This is your first appearance on, is it not? It's really nice to be back in the studio.

-- The ability to predict drug overdose risk from a patient's medical records is crucial for timely intervention and prevention. Traditional machine learning models have shown promise in analyzing longitudinal medical records for this task. However, recent advancements in large language models (LLMs) offer an opportunity to enhance prediction performance by leveraging their ability to process long textual data and their inherent prior knowledge across diverse tasks. In this study, we assess the effectiveness of Open AI's GPT -4o LLM in predicting drug overdose events using patients' longitudinal insurance claims records. We evaluate its performance in both fine-tuned and zero-shot settings, comparing them to strong traditional machine learning methods as baselines. Our results show that LLMs not only outperform traditional models in certain settings but can also predict overdose risk in a zero-shot setting without task-specific training. Drug overdose (OD) is a major public health crisis in the United States, leading to a substantial number of emergency medical interventions and fatalities each year. According to the Centers for Disease Control and Prevention (CDC), drug overdoses claimed approximately 107,941 [1] lives in the U.S. in 2022, highlighting the urgent need for effective prevention and intervention strategies. Besides fatal outcomes and lost quality of life for patients, the misuse of prescription medications, illicit drugs, and polysubstance abuse has placed an immense burden on healthcare systems, emergency responders, and policymakers. Identifying individuals at risk early can facilitate timely interventions, such as targeted clinical assessments, behavioral support, and prescription monitoring, thereby reducing the likelihood of fatal outcomes. Md Sultan Al Nahian is with the Institute for Biomedical Informatics, University of Kentucky, Lexington, KY 40536 USA. Chris Delcher and Daniel Harris are with the Department of Pharmacy Practice and Science, University of Kentucky, Lexington, KY 40536 USA. Peter Akpunonu is with the Department of Emergency Medicine, University of Kentucky, Lexington, KY 40536 USA.

The opioid overdose epidemic remains a critical public health crisis, particularly in the United States, leading to significant mortality and societal costs. Social media platforms like Reddit provide vast amounts of unstructured data that offer insights into public perceptions, discussions, and experiences related to opioid use. This study leverages Natural Language Processing (NLP), specifically Opioid Named Entity Recognition (ONER-2025), to extract actionable information from these platforms. Our research makes four key contributions. First, we created a unique, manually annotated dataset sourced from Reddit, where users share self-reported experiences of opioid use via different administration routes. This dataset contains 331,285 tokens and includes eight major opioid entity categories. Second, we detail our annotation process and guidelines while discussing the challenges of labeling the ONER-2025 dataset. Third, we analyze key linguistic challenges, including slang, ambiguity, fragmented sentences, and emotionally charged language, in opioid discussions. Fourth, we propose a real-time monitoring system to process streaming data from social media, healthcare records, and emergency services to identify overdose events. Using 5-fold cross-validation in 11 experiments, our system integrates machine learning, deep learning, and transformer-based language models with advanced contextual embeddings to enhance understanding. Our transformer-based models (bert-base-NER and roberta-base) achieved 97% accuracy and F1-score, outperforming baselines by 10.23% (RF=0.88).

This paper introduces JiraiBench, the first bilingual benchmark for evaluating large language models' effectiveness in detecting self-destructive content across Chinese and Japanese social media communities. Focusing on the transnational "Jirai" (landmine) online subculture that encompasses multiple forms of self-destructive behaviors including drug overdose, eating disorders, and self-harm, we present a comprehensive evaluation framework incorporating both linguistic and cultural dimensions. Our dataset comprises 10,419 Chinese posts and 5,000 Japanese posts with multidimensional annotation along three behavioral categories, achieving substantial inter-annotator agreement. Experimental evaluations across four state-of-the-art models reveal significant performance variations based on instructional language, with Japanese prompts unexpectedly outperforming Chinese prompts when processing Chinese content. This emergent cross-cultural transfer suggests that cultural proximity can sometimes outweigh linguistic similarity in detection tasks. Cross-lingual transfer experiments with fine-tuned models further demonstrate the potential for knowledge transfer between these language systems without explicit target language training. These findings highlight the need for culturally-informed approaches to multilingual content moderation and provide empirical evidence for the importance of cultural context in developing more effective detection systems for vulnerable online communities.

Optimal allocation of scarce resources is a common problem for decision makers faced with choosing a limited number of locations for intervention. Spatiotemporal prediction models could make such decisions data-driven. A recent performance metric called fraction of best possible reach (BPR) measures the impact of using a model's recommended size K subset of sites compared to the best possible top-K in hindsight. We tackle two open problems related to BPR. First, we explore how to rank all sites numerically given a probabilistic model that predicts event counts jointly across sites. Ranking via the per-site mean is suboptimal for BPR. Instead, we offer a better ranking for BPR backed by decision theory. Second, we explore how to train a probabilistic model's parameters to maximize BPR. Discrete selection of K sites implies all-zero parameter gradients which prevent standard gradient training. We overcome this barrier via advances in perturbed optimizers. We further suggest a training objective that combines likelihood with a decision-aware BPR constraint to deliver high-quality top-K rankings as well as good forecasts for all sites. We demonstrate our approach on two where-to-intervene applications: mitigating opioid-related fatal overdoses for public health and monitoring endangered wildlife.

We present efforts in the fields of machine learning and time series forecasting to accurately predict counts of future opioid overdose incidents recorded by Emergency Medical Services (EMS) in the state of Kentucky. Forecasts are useful to state government agencies to properly prepare and distribute resources related to opioid overdoses effectively. Our approach uses county and district level aggregations of EMS opioid overdose encounters and forecasts future counts for each month. A variety of additional covariates were tested to determine their impact on the model's performance. Models with different levels of complexity were evaluated to optimize training time and accuracy. Our results show that when special precautions are taken to address data sparsity, useful predictions can be generated with limited error by utilizing yearly trends and covariance with additional data sources.

A Lancaster man was indicted Wednesday by a federal grand jury on charges stemming from his alleged use of a drone to deliver fentanyl and other narcotics to buyers, one of whom died of an overdose. Christopher Patrick "Crany" Laney, 34, has been charged with one count of distributing fentanyl resulting in death, four counts of operating an unregistered aircraft in furtherance of a felony narcotics crime, one count of possessing methamphetamine with intent to distribute, two counts of possessing fentanyl with intent to distribute, and one count of possessing firearms in furtherance of a drug trafficking crime, according to the grand jury indictment. Federal prosecutors alleged that on several occasions in December 2022 and January 2023, Laney used an unregistered drone to transport fentanyl and other narcotics from his home to a nearby church parking lot, where someone collected the drugs before distributing them to buyers. At least one of those people included a woman who died of an overdose in January 2023. The federal grand indictment also accuses Laney of being in possession of methamphetamine and fentanyl at his home, along with multiple firearms lacking serial numbers -- weapons that are referred to as "ghost guns."

Since 1999, the opioid epidemic has killed around 645,000 people in America--a number that would no doubt be even higher were it not for naloxone, an opioid antagonist that can effectively reverse the effects of an overdose. However, time is critical: if naloxone is not administered promptly, the victim's chances of survival diminish rapidly. In a paper published August 14 in Device, a team of researchers describe a device designed to detect the signs of an overdose and automatically deliver a dose of naloxone in as little as 10 seconds. The device–which researchers describe as a "robotic first responder"–is named the "implantable system for opioid safety" (iSOS). It's implanted under the user's skin, in the same way as a heart loop recorder.

Risk prediction has permeated many aspects of modern life, including health care. Algorithms developed using advanced statistical methods have been used to identify hospitalized adults at risk of clinical deterioration, reduce hospital readmission rates, and improve resource allocation and health care use. These methods have also been used to develop predictive models for overdose risk among specific patient populations. Most of these overdose-specific applications, however, have been limited to health care settings using health care utilization or insurance claims data. State and local governments are increasingly integrating health- and non-health-sector data for public health purposes, creating an opportunity to use these data to improve overdose risk prediction models.

For many people, the list of their most hotly anticipated video games will include "whatever Hideo Kojima is working on." If you're one of those folks, you may be interested to learn that a video showing the Death Stranding auteur's next title seems to have leaked ahead of a formal reveal from his studio, Kojima Productions. The video, which has been removed from Streamable for violating the platform's terms of service, shows a character who looks like Mama from Death Stranding. That character was played by Maid and Once Upon a Time in Hollywood actor Margaret Qualley. The character shown here navigates dark corridors with the help of a flashlight while an ominous figure follows them.