As the first diagnostic imaging modality of avascular necrosis of the femoral head (AVNFH), accurately staging AVNFH from a plain radiograph is critical and challenging for orthopedists. Thus, we propose a deep learning-based AVNFH diagnosis system (AVN-net). The proposed AVN-net reads plain radiographs of the pelvis, conducts diagnosis, and visualizes results automatically. Deep convolutional neural networks are trained to provide an end-to-end diagnosis solution, covering femoral head detection, exam-view/sides identification, AVNFH diagnosis, and key clinical note generation subtasks. AVN-net is able to obtain state-of-the-art testing AUC of 0.95 (95% CI: 0.92-0.98) in AVNFH detection and significantly greater F1 scores (p<0.01) than less-to-moderately experienced orthopedists in all diagnostic tests. Furthermore, two real-world pilot studies were conducted for diagnosis support and education assistance, respectively, to assess the utility of AVN-net. The experimental results are promising. With the AVN-net diagnosis as a reference, the diagnostic accuracy and consistency of all orthopedists considerably improved while requiring only 1/4 of the time. Students self-studying the AVNFH diagnosis using AVN-net can learn better and faster than the control group. To the best of our knowledge, this study is the first research on the prospective use of a deep learning-based diagnosis system for AVNFH by conducting two pilot studies representing real-world application scenarios. We have demonstrated that the proposed AVN-net achieves expert-level AVNFH diagnosis performance, provides efficient support in clinical decision-making, and effectively passes clinical experience to students.

Artificial intelligence will utterly transform medicine. But one doctor says if done right, AI could put the "care" back in health care. You can get messages right from our hosts (and more opportunities to engage with the show) sent directly to your inbox with the On Point newsletter. "You should have your internist prescribe anti-depression medications," my orthopedist told me. My wife and I looked at each other, bug-eyed, in total disbelief.