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Detecting Data Deviations in Electronic Health Records

Neural Information Processing Systems

Data deviations in electronic health records (EHR) refer to discrepancies between recorded entries and a patient's actual physiological state, indicating a decline in EHR data fidelity. Such deviations can result from pre-analytical variability, documentation errors, or unvalidated data sources. Effectively detecting data deviations is clinically valuable for identifying erroneous records, excluding them from downstream clinical workflows, and informing corrective actions. Despite its importance and practical relevance, this problem remains largely underexplored in existing research. To bridge this gap, we propose a bi-level knowledge distillation approach centered on a task-agnostic formulation of EHR data fidelity as an intrinsic measure of data reliability. Our approach performs layered knowledge distillation in two levels: from a computation-intensive, task-specific data Shapley oracle to a neural oracle for individual tasks, and then to a unified EHR data fidelity predictor. This design enables the integration of task-specific insights into a holistic assessment of a patient's EHR data fidelity from a multi-task perspective. By tracking the outputs of this learned predictor, we detect potential data deviations in EHR data.


Neural Tangent Knowledge Distillation for Optical Convolutional Networks

arXiv.org Artificial Intelligence

Hybrid Optical Neural Networks (ONNs, typically consisting of an optical frontend and a digital backend) offer an energy-efficient alternative to fully digital deep networks for real-time, power-constrained systems. However, their adoption is limited by two main challenges: the accuracy gap compared to large-scale networks during training, and discrepancies between simulated and fabricated systems that further degrade accuracy. While previous work has proposed end-to-end optimizations for specific datasets (e.g., MNIST) and optical systems, these approaches typically lack generalization across tasks and hardware designs. To address these limitations, we propose a task-agnostic and hardware-agnostic pipeline that supports image classification and segmentation across diverse optical systems. To assist optical system design before training, we estimate achievable model accuracy based on user-specified constraints such as physical size and the dataset. For training, we introduce Neural Tangent Knowledge Distillation (NTKD), which aligns optical models with electronic teacher networks, thereby narrowing the accuracy gap. After fabrication, NTKD also guides fine-tuning of the digital backend to compensate for implementation errors. Experiments on multiple datasets (e.g., MNIST, CIFAR, Carvana Masking) and hardware configurations show that our pipeline consistently improves ONN performance and enables practical deployment in both pre-fabrication simulations and physical implementations.


Thermodynamics-Inspired Computing with Oscillatory Neural Networks for Inverse Matrix Computation

arXiv.org Artificial Intelligence

We describe a thermodynamic-inspired computing paradigm based on oscillatory neural networks (ONNs). While ONNs have been widely studied as Ising machines for tackling complex combinatorial optimization problems, this work investigates their feasibility in solving linear algebra problems, specifically the inverse matrix. Grounded in thermodynamic principles, we analytically demonstrate that the linear approximation of the coupled Kuramoto oscillator model leads to the inverse matrix solution. Numerical simulations validate the theoretical framework, and we examine the parameter regimes that computation has the highest accuracy.


Model-free front-to-end training of a large high performance laser neural network

arXiv.org Artificial Intelligence

Artificial neural networks (ANNs), have become ubiquitous and revolutionized many applications ranging from computer vision to medical diagnoses. However, they offer a fundamentally connectionist and distributed approach to computing, in stark contrast to classical computers that use the von Neumann architecture. This distinction has sparked renewed interest in developing unconventional hardware to support more efficient implementations of ANNs, rather than merely emulating them on traditional systems. Photonics stands out as a particularly promising platform, providing scalability, high speed, energy efficiency, and the ability for parallel information processing. However, fully realized autonomous optical neural networks (ONNs) with in-situ learning capabilities are still rare. In this work, we demonstrate a fully autonomous and parallel ONN using a multimode vertical cavity surface emitting laser (VCSEL) using off-the-shelf components. Our ONN is highly efficient and is scalable both in network size and inference bandwidth towards the GHz range. High performance hardware-compatible optimization algorithms are necessary in order to minimize reliance on external von Neumann computers to fully exploit the potential of ONNs. As such we present and extensively study several algorithms which are broadly compatible with a wide range of systems. We then apply these algorithms to optimize our ONN, and benchmark them using the MNIST dataset. We show that our ONN can achieve high accuracy and convergence efficiency, even under limited hardware resources. Crucially, we compare these different algorithms in terms of scaling and optimization efficiency in term of convergence time which is crucial when working with limited external resources. Our work provides some guidance for the design of future ONNs as well as a simple and flexible way to train them.


The Spatial Complexity of Optical Computing and How to Reduce It

arXiv.org Artificial Intelligence

Similar to algorithms, which consume time and memory to run, hardware requires resources to function. For devices processing physical waves, implementing operations needs sufficient "space," as dictated by wave physics. How much space is needed to perform a certain function is a fundamental question in optics, with recent research addressing it for given mathematical operations, but not for more general computing tasks, e.g., classification. Inspired by computational complexity theory, we study the "spatial complexity" of optical computing systems in terms of scaling laws - specifically, how their physical dimensions must scale as the dimension of the mathematical operation increases - and propose a new paradigm for designing optical computing systems: space-efficient neuromorphic optics, based on structural sparsity constraints and neural pruning methods motivated by wave physics (notably, the concept of "overlapping nonlocality"). On two mainstream platforms, free-space optics and on-chip integrated photonics, our methods demonstrate substantial size reductions (to 1%-10% the size of conventional designs) with minimal compromise on performance. Our theoretical and computational results reveal a trend of diminishing returns on accuracy as structure dimensions increase, providing a new perspective for interpreting and approaching the ultimate limits of optical computing - a balanced trade-off between device size and accuracy.


Training Large-Scale Optical Neural Networks with Two-Pass Forward Propagation

arXiv.org Artificial Intelligence

This paper addresses the limitations in Optical Neural Networks (ONNs) related to training efficiency, nonlinear function implementation, and large input data processing. We introduce Two-Pass Forward Propagation, a novel training method that avoids specific nonlinear activation functions by modulating and re-entering error with random noise. Additionally, we propose a new way to implement convolutional neural networks using simple neural networks in integrated optical systems. Theoretical foundations and numerical results demonstrate significant improvements in training speed, energy efficiency, and scalability, advancing the potential of optical computing for complex data tasks.


Training neural networks with end-to-end optical backpropagation

arXiv.org Artificial Intelligence

Optics is an exciting route for the next generation of computing hardware for machine learning, promising several orders of magnitude enhancement in both computational speed and energy efficiency. However, to reach the full capacity of an optical neural network it is necessary that the computing not only for the inference, but also for the training be implemented optically. The primary algorithm for training a neural network is backpropagation, in which the calculation is performed in the order opposite to the information flow for inference. While straightforward in a digital computer, optical implementation of backpropagation has so far remained elusive, particularly because of the conflicting requirements for the optical element that implements the nonlinear activation function. In this work, we address this challenge for the first time with a surprisingly simple and generic scheme. Saturable absorbers are employed for the role of the activation units, and the required properties are achieved through a pump-probe process, in which the forward propagating signal acts as the pump and backward as the probe. Our approach is adaptable to various analog platforms, materials, and network structures, and it demonstrates the possibility of constructing neural networks entirely reliant on analog optical processes for both training and inference tasks.


Hybrid training of optical neural networks

#artificialintelligence

Optical neural networks are emerging as a promising type of machine learning hardware capable of energy-efficient, parallel computation. Today's optical neural networks are mainly developed to perform optical inference after in silico training on digital simulators. However, various physical imperfections that cannot be accurately modeled may lead to the notorious "reality gap" between the digital simulator and the physical system. To address this challenge, we demonstrate hybrid training of optical neural networks where the weight matrix is trained with neuron activation functions computed optically via forward propagation through the network. We examine the efficacy of hybrid training with three different networks: an optical linear classifier, a hybrid opto-electronic network, and a complex-valued optical network. We perform a study comparative to in silico training, and our results show that hybrid training is robust against different kinds of static noise. Our platform-agnostic hybrid training scheme can be applied to a wide variety of optical neural networks, and this work paves the way towards advanced all-optical training in machine intelligence. Published by Optica Publishing Group under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Machine learning powered by artificial neural networks has reshaped the landscape in many different areas over the last decade.


Exploiting Heterogeneity in Operational Neural Networks by Synaptic Plasticity

arXiv.org Machine Learning

The recently proposed network model, Operational Neural Networks (ONNs), can generalize the conventional Convolutional Neural Networks (CNNs) that are homogenous only with a linear neuron model. As a heterogenous network model, ONNs are based on a generalized neuron model that can encapsulate any set of non-linear operators to boost diversity and to learn highly complex and multi-modal functions or spaces with minimal network complexity and training data. However, the default search method to find optimal operators in ONNs, the so-called Greedy Iterative Search (GIS) method, usually takes several training sessions to find a single operator set per layer. This is not only computationally demanding, also the network heterogeneity is limited since the same set of operators will then be used for all neurons in each layer. To address this deficiency and exploit a superior level of heterogeneity, in this study the focus is drawn on searching the best-possible operator set(s) for the hidden neurons of the network based on the Synaptic Plasticity paradigm that poses the essential learning theory in biological neurons. During training, each operator set in the library can be evaluated by their synaptic plasticity level, ranked from the worst to the best, and an elite ONN can then be configured using the top ranked operator sets found at each hidden layer. Experimental results over highly challenging problems demonstrate that the elite ONNs even with few neurons and layers can achieve a superior learning performance than GIS-based ONNs and as a result the performance gap over the CNNs further widens.


Operation-aware Neural Networks for User Response Prediction

arXiv.org Machine Learning

User response prediction makes a crucial contribution to the rapid development of online advertising system and recommendation system. The importance of learning feature interactions has been emphasized by many works. Many deep models are proposed to automatically learn high-order feature interactions. Since most features in advertising system and recommendation system are high-dimensional sparse features, deep models usually learn a low-dimensional distributed representation for each feature in the bottom layer. Besides traditional fully-connected architectures, some new operations, such as convolutional operations and product operations, are proposed to learn feature interactions better. In these models, the representation is shared among different operations. However, the best representation for different operations may be different. In this paper, we propose a new neural model named Operation-aware Neural Networks (ONN) which learns different representations for different operations. Our experimental results on two large-scale real-world ad click/conversion datasets demonstrate that ONN consistently outperforms the state-of-the-art models in both offline-training environment and online-training environment.