neurotransmitter
Cortisol could impact your dog's behavior
Environment Animals Pets Dogs Cortisol could impact your dog's behavior Just like in humans, stress and mood hormones might play a role in your pet's temperament. Breakthroughs, discoveries, and DIY tips sent six days a week. For dogs, good training and responsible ownership impact their behavior, but their life experiences and genetics can also affect temperament. Hormones may also play a role and could offer a new way to assess our canine companions. In a small study published today in the journal more well-behaved dogs generally had lower levels of cortisol--an important stress hormone--and higher levels of serotonin, a neurotransmitter associated with happiness.
Mind the Quote: Enabling Quotation-Aware Dialogue in LLMs via Plug-and-Play Modules
Zhang, Yueqi, Yuan, Peiwen, Feng, Shaoxiong, Li, Yiwei, Wang, Xinglin, Shi, Jiayi, Tan, Chuyi, Pan, Boyuan, Hu, Yao, Li, Kan
Human-AI conversation frequently relies on quoting earlier text-"check it with the formula I just highlighted"-yet today's large language models (LLMs) lack an explicit mechanism for locating and exploiting such spans. We formalise the challenge as span-conditioned generation, decomposing each turn into the dialogue history, a set of token-offset quotation spans, and an intent utterance. Building on this abstraction, we introduce a quotation-centric data pipeline that automatically synthesises task-specific dialogues, verifies answer correctness through multi-stage consistency checks, and yields both a heterogeneous training corpus and the first benchmark covering five representative scenarios. To meet the benchmark's zero-overhead and parameter-efficiency requirements, we propose QuAda, a lightweight training-based method that attaches two bottleneck projections to every attention head, dynamically amplifying or suppressing attention to quoted spans at inference time while leaving the prompt unchanged and updating < 2.8% of backbone weights. Experiments across models show that QuAda is suitable for all scenarios and generalises to unseen topics, offering an effective, plug-and-play solution for quotation-aware dialogue.
- Africa > Middle East > Egypt (0.46)
- Asia > Middle East > Israel (0.28)
- Law (1.00)
- Health & Medicine > Therapeutic Area > Neurology (1.00)
- Government > Regional Government (1.00)
- (6 more...)
Messing with mouse brains during sex leads to unexpected discovery
Sex comprises an intricate tangle of impulses and interactions between partners. Neuroscientists have learned a great deal about the neural mechanisms underlying sex, but questions about the processes that control the sequence of events during sex remain unanswered. While past research has identified the regions of the brain that control how mice initiate sex, other steps of copulation are still mysteries. A team of researchers in China and Japan have investigated which brain regions and neurotransmitters are responsible for different phases during sex. A paper published March 19 in the journal Neuron describes what exactly goes on in a mouse brain during sex.
- North America > United States > New York (0.05)
- Asia > Japan > Honshū > Kantō > Ibaraki Prefecture > Tsukuba (0.05)
- Asia > China > Shaanxi Province > Xi'an (0.05)
A Synaptical Story of Persistent Activity with Graded Lifetime in a Neural System
Yuanyuan Mi, Luozheng Li, Dahui Wang, Si Wu
Persistent activity refers to the phenomenon that cortical neurons keep firing even after the stimulus triggering the initial neuronal responses is moved. Persistent activity is widely believed to be the substrate for a neural system retaining a memory trace of the stimulus information. In a conventional view, persistent activity is regarded as an attractor of the network dynamics, but it faces a challenge of how to be closed properly. Here, in contrast to the view of attractor, we consider that the stimulus information is encoded in a marginally unstable state of the network which decays very slowly and exhibits persistent firing for a prolonged duration. We propose a simple yet effective mechanism to achieve this goal, which utilizes the property of short-term plasticity (STP) of neuronal synapses. STP has two forms, short-term depression (STD) and short-term facilitation (STF), which have opposite effects on retaining neuronal responses. We find that by properly combining STF and STD, a neural system can hold persistent activity of graded lifetime, and that persistent activity fades away naturally without relying on an external drive. The implications of these results on neural information representation are discussed.
- Asia > China > Beijing > Beijing (0.05)
- North America > United States > New York (0.04)
- Europe > United Kingdom > England > Cambridgeshire > Cambridge (0.04)
- Asia > China > Jiangsu Province (0.04)
Mapping the shifting gaze of 'fishlets'
They have Wolverine-like regeneration abilities–and can almost entirely regrow their spinal cords after damage. They also give scientists insight into some of the animal brain's most primal states. While working with week-old zebrafish larvae, a team of scientists decoded how the connections made by a network of neurons in the brainstem guide where the fish looks. They also created a simplified artificial circuit that can predict visual movement and activity in the animal's brain. This discovery sheds light on how the brain handles short-term memory and could lead to some new ways to treat eye movement disorders in humans.
Explainable Deep Learning Framework for SERS Bio-quantification
Zaki, Jihan K., Tomasik, Jakub, McCune, Jade A., Bahn, Sabine, Liò, Pietro, Scherman, Oren A.
Surface-enhanced Raman spectroscopy (SERS) is a potential fast and inexpensive method of analyte quantification, which can be combined with deep learning to discover biomarker-disease relationships. This study aims to address present challenges of SERS through a novel SERS bio-quantification framework, including spectral processing, analyte quantification, and model explainability. To this end,serotonin quantification in urine media was assessed as a model task with 682 SERS spectra measured in a micromolar range using cucurbit[8]uril chemical spacers. A denoising autoencoder was utilized for spectral enhancement, and convolutional neural networks (CNN) and vision transformers were utilized for biomarker quantification. Lastly, a novel context representative interpretable model explanations (CRIME) method was developed to suit the current needs of SERS mixture analysis explainability. Serotonin quantification was most efficient in denoised spectra analysed using a convolutional neural network with a three-parameter logistic output layer (mean absolute error = 0.15 {\mu}M, mean percentage error = 4.67%). Subsequently, the CRIME method revealed the CNN model to present six prediction contexts, of which three were associated with serotonin. The proposed framework could unlock a novel, untargeted hypothesis generating method of biomarker discovery considering the rapid and inexpensive nature of SERS measurements, and the potential to identify biomarkers from CRIME contexts.
- Europe > United Kingdom > England > Cambridgeshire > Cambridge (0.05)
- North America > Mexico > Puebla (0.04)
- Europe > United Kingdom > England > Oxfordshire > Oxford (0.04)
- (2 more...)
- Health & Medicine > Therapeutic Area > Psychiatry/Psychology (1.00)
- Health & Medicine > Pharmaceuticals & Biotechnology (1.00)
- Health & Medicine > Therapeutic Area > Oncology (0.93)
Pay attention! 12 ways to improve your focus and concentration span
That was the average length of time an adult could focus on a screen for in 2021, according to research by Gloria Mark, a professor of informatics at the University of California. Twenty years ago, in 2004, that number stood at two-and-a-half minutes. Our attention spans – how long we're able to concentrate without being distracted – are shrinking. Our focus – how intensely we can think about things – is suffering too. The causes: technology that's designed to demand our attention; endless tools for procrastination at our fingertips; rising stress and anxiety disorders; and poor sleep quality.
- Health & Medicine > Therapeutic Area > Psychiatry/Psychology > Mental Health (1.00)
- Health & Medicine > Therapeutic Area > Neurology (1.00)
- Health & Medicine > Consumer Health (1.00)
Scientists mapped every neuron of an adult animal's brain for the first time
Brains are bewilderingly complicated systems of connections between neurons. Mapping those connections is an important step in understanding how brains work. Scientists have recently completed the most ambitious effort yet to construct such a map: a complete document of every neuron and every connection in the brain of an adult fruit fly. The research represents the first such map for an animal that can walk and see, and the first complete map of the brain of an adult animal. It traces each and every one of the 139,255 neurons in the brain of Drosophila melanogaster, along with the 50 million connections between them, and is by far the largest and most detailed ever produced.
- North America > United States > New York (0.05)
- Europe > United Kingdom > England > Cambridgeshire > Cambridge (0.05)
A Synaptical Story of Persistent Activity with Graded Lifetime in a Neural System
Persistent activity refers to the phenomenon that cortical neurons keep firing even after the stimulus triggering the initial neuronal responses is moved. Persistent activity is widely believed to be the substrate for a neural system retaining a memory trace of the stimulus information. In a conventional view, persistent activity is regarded as an attractor of the network dynamics, but it faces a challenge of how to be closed properly. Here, in contrast to the view of attractor, we consider that the stimulus information is encoded in a marginally unstable state of the network which decays very slowly and exhibits persistent firing for a prolonged duration. We propose a simple yet effective mechanism to achieve this goal, which utilizes the property of short-term plasticity (STP) of neuronal synapses. STP has two forms, short-term depression (STD) and short-term facilitation (STF), which have opposite effects on retaining neuronal responses. We find that by properly combining STF and STD, a neural system can hold persistent activity of graded lifetime, and that persistent activity fades away naturally without relying on an external drive. The implications of these results on neural information representation are discussed.
- Asia > China > Beijing > Beijing (0.05)
- North America > United States > New York (0.04)
- Europe > United Kingdom > England > Cambridgeshire > Cambridge (0.04)
- Asia > China > Jiangsu Province (0.04)
Navigating 2024 with strategies tailored for those suffering from anxiety, depression, ADHD
Fox News Flash top headlines are here. Check out what's clicking on Foxnews.com. The journey toward improved mental health by setting thoughtful and achievable goals can be a powerful strategy. Whether grappling with anxiety, depression, ADHD or other conditions, establishing personalized goals fosters a sense of direction, accomplishment and empowerment. Explore specific goals tailored to each condition, promoting overall mental well-being.