Remarkable strides in computational pathology have been made in the task-agnostic foundation model that advances the performance of a wide array of downstream clinical tasks. Despite the promising performance, there are still several challenges. First, prior works have resorted to either vision-only or vision-captions data, disregarding invaluable pathology reports and gene expression profiles which respectively offer distinct knowledge for versatile clinical applications. Second, the current progress in pathology FMs predominantly concentrates on the patch level, where the restricted context of patch-level pretraining fails to capture whole-slide patterns. Here we curated the largest multimodal dataset consisting of H\&E diagnostic whole slide images and their associated pathology reports and RNA-Seq data, resulting in 26,169 slide-level modality pairs from 10,275 patients across 32 cancer types. To leverage these data for CPath, we propose a novel whole-slide pretraining paradigm which injects multimodal knowledge at the whole-slide context into the pathology FM, called Multimodal Self-TAught PRetraining (mSTAR). The proposed paradigm revolutionizes the workflow of pretraining for CPath, which enables the pathology FM to acquire the whole-slide context. To our knowledge, this is the first attempt to incorporate multimodal knowledge at the slide level for enhancing pathology FMs, expanding the modelling context from unimodal to multimodal knowledge and from patch-level to slide-level. To systematically evaluate the capabilities of mSTAR, extensive experiments including slide-level unimodal and multimodal applications, are conducted across 7 diverse types of tasks on 43 subtasks, resulting in the largest spectrum of downstream tasks. The average performance in various slide-level applications consistently demonstrates significant performance enhancements for mSTAR compared to SOTA FMs.

Knowledge graphs (KGs) are widely acknowledged as incomplete, and new entities are constantly emerging in the real world. Inductive KG reasoning aims to predict missing facts for these new entities. Among existing models, graph neural networks (GNNs) based ones have shown promising performance for this task. However, they are still challenged by inefficient message propagation due to the distance and scalability issues. In this paper, we propose a new inductive KG reasoning model, MStar, by leveraging conditional message passing neural networks (C-MPNNs). Our key insight is to select multiple query-specific starting entities to expand the scope of progressive propagation. To propagate query-related messages to a farther area within limited steps, we subsequently design a highway layer to propagate information toward these selected starting entities. Moreover, we introduce a training strategy called LinkVerify to mitigate the impact of noisy training samples. Experimental results validate that MStar achieves superior performance compared with state-of-the-art models, especially for distant entities.