morphology
Leveraging an ECG Beat Diffusion Model for Morphological Reconstruction from Indirect Signals
Electrocardiogram (ECG) signals provide essential information about the heart's condition and are widely used for diagnosing cardiovascular diseases. The morphology of a single heartbeat over the available leads is a primary biosignal for monitoring cardiac conditions. However, analyzing heartbeat morphology can be challenging due to noise and artifacts, missing leads, and a lack of annotated data.Generative models, such as denoising diffusion generative models (DDMs), have proven successful in generating complex data. We introduce $\texttt{BeatDiff}$, a light-weight DDM tailored for the morphology of multiple leads heartbeats.We then show that many important ECG downstream tasks can be formulated as conditional generation methods in a Bayesian inverse problem framework using $\texttt{BeatDiff}$ as priors. We propose $\texttt{EM-BeatDiff}$, an Expectation-Maximization algorithm, to solve this conditional generation tasks without fine-tuning. We illustrate our results with several tasks, such as removal of ECG noise and artifacts (baseline wander, electrode motion), reconstruction of a 12-lead ECG from a single lead (useful for ECG reconstruction of smartwatch experiments), and unsupervised explainable anomaly detection. Numerical experiments show that the combination of $\texttt{BeatDiff}$ and $\texttt{EM-BeatDiff}$ outperforms SOTA methods for the problems considered in this work.
Learning to Control Self-Assembling Morphologies: A Study of Generalization via Modularity
Contemporary sensorimotor learning approaches typically start with an existing complex agent (e.g., a robotic arm), which they learn to control. In contrast, this paper investigates a modular co-evolution strategy: a collection of primitive agents learns to dynamically self-assemble into composite bodies while also learning to coordinate their behavior to control these bodies. Each primitive agent consists of a limb with a motor attached at one end. Limbs may choose to link up to form collectives. When a limb initiates a link-up action and there is another limb nearby, the latter is magnetically connected to the'parent' limb's motor.
Beyond the Failures: Rethinking Foundation Models in Pathology
Despite their successes in vision and language, foundation models have stumbled in pathology, revealing low accuracy, instability, and heavy computational demands. These shortcomings stem not from tuning problems but from deeper conceptual mismatches: dense embeddings cannot represent the combinatorial richness of tissue, and current architectures inherit flaws in self-supervision, patch design, and noise-fragile pretraining. Biological complexity and limited domain innovation further widen the gap. The evidence is clear--pathology requires models explicitly designed for biological images rather than adaptations of large-scale natural-image methods whose assumptions do not hold for tissue.
- Health & Medicine > Therapeutic Area > Oncology (0.46)
- Health & Medicine > Diagnostic Medicine > Imaging (0.46)
Knowledge Diversion for Efficient Morphology Control and Policy Transfer
Feng, Fu, Shi, Ruixiao, Xie, Yucheng, Shen, Jianlu, Wang, Jing, Geng, Xin
Universal morphology control aims to learn a universal policy that generalizes across heterogeneous agent morphologies, with Transformer-based controllers emerging as a popular choice. However, such architectures incur substantial computational costs, resulting in high deployment overhead, and existing methods exhibit limited cross-task generalization, necessitating training from scratch for each new task. To this end, we propose \textbf{DivMorph}, a modular training paradigm that leverages knowledge diversion to learn decomposable controllers. DivMorph factorizes randomly initialized Transformer weights into factor units via SVD prior to training and employs dynamic soft gating to modulate these units based on task and morphology embeddings, separating them into shared \textit{learngenes} and morphology- and task-specific \textit{tailors}, thereby achieving knowledge disentanglement. By selectively activating relevant components, DivMorph enables scalable and efficient policy deployment while supporting effective policy transfer to novel tasks. Extensive experiments demonstrate that DivMorph achieves state-of-the-art performance, achieving a 3$\times$ improvement in sample efficiency over direct finetuning for cross-task transfer and a 17$\times$ reduction in model size for single-agent deployment.
AraLingBench A Human-Annotated Benchmark for Evaluating Arabic Linguistic Capabilities of Large Language Models
Zbeeb, Mohammad, Hammoud, Hasan Abed Al Kader, Mukalled, Sina, Rizk, Nadine, Karnib, Fatima, Lakkis, Issam, Mohanna, Ammar, Ghanem, Bernard
The benchmark spans five core categories: grammar, morphology, spelling, reading comprehension, and syntax, through 150 expert-designed multiple choice questions that directly assess structural language understanding. Evaluating 35 Arabic and bilingual LLMs reveals that current models demonstrate strong surface level proficiency but struggle with deeper grammatical and syntactic reasoning. AraLingBench highlights a persistent gap between high scores on knowledge-based benchmarks and true linguistic mastery, showing that many models succeed through memorization or pattern recognition rather than authentic comprehension. By isolating and measuring fundamental linguistic skills, AraLingBench provides a diagnostic framework for developing Arabic LLMs. The full evaluation code is publicly available on GitHub.
- Europe > Austria > Vienna (0.14)
- Asia > Middle East > UAE > Abu Dhabi Emirate > Abu Dhabi (0.14)
- Asia > Middle East > Lebanon > Beirut Governorate > Beirut (0.05)
- (10 more...)
- Research Report (0.51)
- Questionnaire & Opinion Survey (0.34)
Morphologically-Informed Tokenizers for Languages with Non-Concatenative Morphology: A case study of Yoloxóchtil Mixtec ASR
This paper investigates the impact of using morphologically-informed tokenizers to aid and streamline the interlinear gloss annotation of an audio corpus of Yoloxóchitl Mixtec (YM) using a combination of ASR and text-based sequence-to-sequence tools, with the goal of improving efficiency while reducing the workload of a human annotator. We present two novel tokenization schemes that separate words in a nonlinear manner, preserving information about tonal morphology as much as possible. One of these approaches, a Segment and Melody tokenizer, simply extracts the tones without predicting segmentation. The other, a Sequence of Processes tokenizer, predicts segmentation for the words, which could allow an end-to-end ASR system to produce segmented and unsegmented transcriptions in a single pass. We find that these novel tokenizers are competitive with BPE and Unigram models, and the Segment-and-Melody model outperforms traditional tokenizers in terms of word error rate but does not reach the same character error rate. In addition, we analyze tokenizers on morphological and information-theoretic metrics to find predictive correlations with downstream performance. Our results suggest that nonlinear tokenizers designed specifically for the non-concatenative morphology of a language are competitive with conventional BPE and Unigram models for ASR. Further research will be necessary to determine the applicability of these tokenizers in downstream processing tasks.
- Europe > Middle East > Republic of Türkiye > Istanbul Province > Istanbul (0.04)
- Europe > Germany > Saxony > Leipzig (0.04)
- Asia > Middle East > Republic of Türkiye > Istanbul Province > Istanbul (0.04)
- (8 more...)
- Information Technology > Artificial Intelligence > Representation & Reasoning (1.00)
- Information Technology > Artificial Intelligence > Natural Language (1.00)
- Information Technology > Artificial Intelligence > Speech > Speech Recognition (0.93)
- Information Technology > Artificial Intelligence > Machine Learning > Performance Analysis > Accuracy (0.68)
H-Zero: Cross-Humanoid Locomotion Pretraining Enables Few-shot Novel Embodiment Transfer
Lin, Yunfeng, Liu, Minghuan, Xue, Yufei, Zhou, Ming, Yu, Yong, Pang, Jiangmiao, Zhang, Weinan
The rapid advancement of humanoid robotics has intensified the need for robust and adaptable controllers to enable stable and efficient locomotion across diverse platforms. However, developing such controllers remains a significant challenge because existing solutions are tailored to specific robot designs, requiring extensive tuning of reward functions, physical parameters, and training hyperparameters for each embodiment. To address this challenge, we introduce H-Zero, a cross-humanoid locomotion pretraining pipeline that learns a generalizable humanoid base policy. We show that pretraining on a limited set of embodiments enables zero-shot and few-shot transfer to novel humanoid robots with minimal fine-tuning. Evaluations show that the pretrained policy maintains up to 81% of the full episode duration on unseen robots in simulation while enabling few-shot transfer to unseen humanoids and upright quadrupeds within 30 minutes of fine-tuning.
- Asia > China > Shanghai > Shanghai (0.04)
- Europe > United Kingdom > England > Greater London > London (0.04)
- Information Technology > Artificial Intelligence > Robots > Locomotion (0.69)
- Information Technology > Artificial Intelligence > Machine Learning > Neural Networks (0.68)
- Information Technology > Artificial Intelligence > Machine Learning > Learning Graphical Models > Undirected Networks > Markov Models (0.46)
Translating Cultural Choreography from Humanoid Forms to Robotic Arm
Chen, Chelsea-Xi, Zhang, Zhe, Zhou, Aven-Le
Robotic arm choreography often reproduces trajectories while missing cultural semantics. This study examines whether symbolic posture transfer with joint space compatible notation can preserve semantic fidelity on a six-degree-of-freedom arm and remain portable across morphologies. We implement ROPERA, a three-stage pipeline for encoding culturally codified postures, composing symbolic sequences, and decoding to servo commands. A scene from Kunqu opera, \textit{The Peony Pavilion}, serves as the material for evaluation. The procedure includes corpus-based posture selection, symbolic scoring, direct joint angle execution, and a visual layer with light painting and costume-informed colors. Results indicate reproducible execution with intended timing and cultural legibility reported by experts and audiences. The study points to non-anthropocentric cultural preservation and portable authoring workflows. Future work will design dance-informed transition profiles, extend the notation to locomotion with haptic, musical, and spatial cues, and test portability across platforms.
- Asia > China > Shaanxi Province > Xi'an (0.05)
- Asia > China > Shanghai > Shanghai (0.04)
- North America > Canada > Nova Scotia > Halifax Regional Municipality > Halifax (0.04)
- (3 more...)
TRIDENT: A Trimodal Cascade Generative Framework for Drug and RNA-Conditioned Cellular Morphology Synthesis
Peng, Rui, Liu, Ziru, Ye, Lingyuan, Lu, Yuxing, Shi, Boxin, Wang, Jinzhuo
Accurately modeling the relationship between perturbations, transcriptional responses, and phenotypic changes is essential for building an AI Virtual Cell (AIVC). However, existing methods typically constrained to modeling direct associations, such as Perturbation $\rightarrow$ RNA or Perturbation $\rightarrow$ Morphology, overlook the crucial causal link from RNA to morphology. To bridge this gap, we propose TRIDENT, a cascade generative framework that synthesizes realistic cellular morphology by conditioning on both the perturbation and the corresponding gene expression profile. To train and evaluate this task, we construct MorphoGene, a new dataset pairing L1000 gene expression with Cell Painting images for 98 compounds. TRIDENT significantly outperforms state-of-the-art approaches, achieving up to 7-fold improvement with strong generalization to unseen compounds. In a case study on docetaxel, we validate that RNA-guided synthesis accurately produces the corresponding phenotype. An ablation study further confirms that this RNA conditioning is essential for the model's high fidelity. By explicitly modeling transcriptome-phenome mapping, TRIDENT provides a powerful in silico tool and moves us closer to a predictive virtual cell.
- Health & Medicine > Pharmaceuticals & Biotechnology (1.00)
- Health & Medicine > Therapeutic Area > Oncology (0.68)