Semantic segmentation has achieved great success in ideal conditions. However, when facing extreme conditions (e.g., insufficient light, fierce camera motion), most existing methods suffer from significant information loss of RGB, severely damaging segmentation results. Several researches exploit the high-speed and high-dynamic event modality as a complement, but event and RGB are naturally heterogeneous, which leads to feature-level mismatch and inferior optimization of existing multi-modality methods. Different from these researches, we delve into the edge secret of both modalities for resilient fusion and propose a novel Edge-awareness Semantic Concordance framework to unify the multi-modality heterogeneous features with latent edge cues. In this framework, we first propose Edge-awareness Latent Re-coding, which obtains uncertainty indicators while realigning event-RGB features into unified semantic space guided by re-coded distribution, and transfers event-RGB distributions into re-coded features by utilizing a pre-established edge dictionary as clues. We then propose Re-coded Consolidation and Uncertainty Optimization, which utilize re-coded edge features and uncertainty indicators to solve the heterogeneous event-RGB fusion issues under extreme conditions. We establish two synthetic and one real-world event-RGB semantic segmentation datasets for extreme scenario comparisons. Experimental results show that our method outperforms the state-of-the-art by a 2.55% mIoU on our proposed DERS-XS, and possesses superior resilience under spatial occlusion. Our code and datasets are publicly available at https://github.com/iCVTEAM/ESC.

Crossmodal matching in single-cell omics is essential for explaining biological regulatory mechanisms and enhancing downstream analyses. However, current single-cell crossmodal models often suffer from three limitations: sparse modality signals, underutilization of biological attributes, and insufficient modeling of regulatory interactions. These challenges hinder generalization in data-scarce settings and restrict the ability to uncover fine-grained biologically meaningful crossmodal relationships. Here, we present a novel framework which reformulates crossmodal matching as a graph classification task on Attributed Bipartite Graphs (ABGs). It models single-cell ATAC-RNA data as an ABG, where each expressed ATAC and RNA is treated as a distinct node with unique IDs and biological features. To model crossmodal interaction patterns on the constructed ABG, we propose Bi2Former, a biologically-driven bipartite graph transformer that learns interpretable attention over ATAC-RNA pairs. This design enables the model to effectively learn and explain biological regulatory relationships between ATAC and RNA modalities. Extensive experiments demonstrate that Bi2Former achieves state-of-the-art performance in crossmodal matching across diverse datasets, remains robust under sparse training data, generalizes to unseen cell types and datasets, and reveals biologically meaningful regulatory patterns.

Multimodal learning holds promise for richer information extraction by capturing dependencies across data sources. Yet, current training methods often underperform due to modality competition, a phenomenon where modalities contend for training resources leaving some underoptimized. This raises a pivotal question: how can we address training imbalances, ensure adequate optimization across all modalities, and achieve consistent performance improvements as we transition from unimodal to multimodal data? This paper proposes the Multimodal Competition Regularizer (MCR), inspired by a mutual information (MI) decomposition designed to prevent the adverse effects of competition in multimodal training. Our key contributions are: 1) A game-theoretic framework that adaptively balances modality contributions by encouraging each to maximize its informative role in the final prediction 2) Refining lower and upper bounds for each MI term to enhance the extraction of both taskrelevant unique and shared information across modalities.

Multi-modal learning has emerged as a key technique for improving performance across domains such as autonomous driving, robotics, and reasoning. However, in certain scenarios, particularly in resource-constrained environments, some modalities available during training may be absent during inference. While existing frameworks effectively utilize multiple data sources during training and enable inference with reduced modalities, they are primarily designed for single-agent settings. This poses a critical limitation in dynamic environments such as connected autonomous vehicles (CAV), where incomplete data coverage can lead to decisionmaking blind spots. Conversely, some works explore multi-agent collaboration but without addressing missing modality at test time. To overcome these limitations, we propose Collaborative Auxiliary Modality Learning (CAML), a novel multi-modal multi-agent framework that enables agents to collaborate and share multi-modal data during training, while allowing inference with reduced modalities during testing. Experimental results in collaborative decision-making for CAV in accident-prone scenarios demonstrate that CAML achieves up to a 58.1%improvement in accident detection.

Multimodal Sentiment Analysis (MSA) aims to infer human emotions by integrating complementary signals from diverse modalities. However, in real-world scenarios, missing modalities are common due to data corruption, sensor failure, or privacy concerns, which can significantly degrade model performance. To tackle this challenge, we propose Hyper-Modality Enhancement (HME), a novel framework that avoids explicit modality reconstruction by enriching each observed modality with semantically relevant cues retrieved from other samples. This cross-sample enhancement reduces reliance on fully observed data during training, making the method better suited to scenarios with inherently incomplete inputs. In addition, we introduce an uncertainty-aware fusion mechanism that adaptively balances original and enriched representations to improve robustness. Extensive experiments on three public benchmarks show that HME consistently outperforms state-of-the-art methods under various missing modality conditions, demonstrating its practicality in real-world MSA applications.

Understanding cellular responses to chemical interventions is critical to the discovery of effective therapeutics. Because individual biological techniques often measure only one axis of cellular response at a time, high-quality multimodal datasets are needed to unlock a holistic understanding of how cells respond to treatments and to advance computational methods that integrate modalities. However, many techniques destroy cells and thus preclude paired measurements, and attempts to match disparate unimodal datasets are often confounded by data being generated in incompatible experimental settings. Here we introduce scGeneScope, a multimodal single-cell RNA sequencing (scRNA-seq) and Cell Painting microscopy image dataset conditionally paired by chemical treatment, designed to facilitate the development and benchmarking of unimodal, multimodal, and multiple profile machine learning methods for cellular profiling.

Multimodal learning has gained much success in recent years. However, current multimodal fusion methods adopt the attention mechanism of Transformers to implicitly learn the underlying correlation of multimodal features.

Time series analysis provides essential insights for real-world system dynamics and informs downstream decision-making, yet most existing methods often overlook the rich contextual signals present in auxiliary modalities. To bridge this gap, we introduce TimeXL, a multi-modal prediction framework that integrates a prototypebased time series encoder with three collaborating Large Language Models (LLMs) to deliver more accurate predictions and interpretable explanations. First, a multimodal prototype-based encoder processes both time series and textual inputs to generate preliminary forecasts alongside case-based rationales. These outputs then feed into a prediction LLM, which refines the forecasts by reasoning over the encoder's predictions and explanations. Next, a reflection LLM compares the predicted values against the ground truth, identifying textual inconsistencies or noise. Guided by this feedback, a refinement LLM iteratively enhances text quality and triggers encoder retraining. This closed-loop workflow--prediction, critique (reflect), and refinement--continuously boosts the framework's performance and interpretability. Empirical evaluations on four real-world datasets demonstrate that TimeXL achieves up to 8.9% improvement in AUC and produces human-centric, multi-modal explanations, highlighting the power of LLM-driven reasoning for time series prediction.

Multi-modal models are data hungry. While datasets with natural images are abundant, medical image datasets can not afford the same luxury. To enable representation learning for medical images at scale, we turn to YouTube, a platform with a large reservoir of open-source medical pedagogical videos. We curate MedicalNarratives, a dataset 4.7M medical image-text pairs, with 1M samples containing dense annotations in the form of spatial traces (and bounding boxes), and 118K videos centered on the trace event (with aligned text), enabling spatiotemporal grounding beyond single frames. Similar to think-aloud studies where instructors speak while hovering their mouse cursor movements over relevant image regions, 1M images in MedicalNarratives contains localized mouse traces in image pixels, creating a spatial and temporal association between the text and pixels. To evaluate the utility of MedicalNarratives, we train GENMEDCLIP with a CLIP-like objective using our dataset spanning 12 medical domains. GENMEDCLIP outperforms previous state-of-the-art models on all 12 domains on a newly constructed medical imaging benchmark.

Deep learning techniques have driven significant progress in various analytical tasks within 3D genomics in computational biology. However, a holistic understanding of 3D genomics knowledge remains underexplored. Here, we propose MIX-HIC, the first multimodal foundation model of 3D genome that integrates both Hi-C contact maps and epigenomic tracks, which obtains unified and comprehensive semantics.