The evolution toward 6G networks is being accelerated by the Open Radio Access Network (O-RAN) paradigm -- an open, interoperable architecture that enables intelligent, modular applications across public telecom and private enterprise domains. While this openness creates unprecedented opportunities for innovation, it also expands the attack surface, demanding resilient, low-cost, and autonomous security solutions. Legacy defenses remain largely reactive, labor-intensive, and inadequate for the scale and complexity of next-generation systems. Current O-RAN applications focus mainly on network optimization or passive threat detection, with limited capability for closed-loop, automated response. To address this critical gap, we present an agentic AI framework for fully automated, end-to-end threat mitigation in 6G O-RAN environments. MobiLLM orchestrates security workflows through a modular multi-agent system powered by Large Language Models (LLMs). The framework features a Threat Analysis Agent for real-time data triage, a Threat Classification Agent that uses Retrieval-Augmented Generation (RAG) to map anomalies to specific countermeasures, and a Threat Response Agent that safely operationalizes mitigation actions via O-RAN control interfaces. Grounded in trusted knowledge bases such as the MITRE FiGHT framework and 3GPP specifications, and equipped with robust safety guardrails, MobiLLM provides a blueprint for trustworthy AI-driven network security. Initial evaluations demonstrate that MobiLLM can effectively identify and orchestrate complex mitigation strategies, significantly reducing response latency and showcasing the feasibility of autonomous security operations in 6G.

There is a huge gap between numerous intriguing applications fostered by on-device large language model (LLM) fine-tuning (FT) from fresh mobile data and the limited resources of a mobile device. While existing server-assisted methods (e.g., split learning or side-tuning) may enable LLM FT on the local mobile device, they suffer from heavy communication burdens of activation transmissions, and may disclose data and labels to the server. To address those issues, we develop PAE MobiLLM, a a privacy-aware and efficient LLM FT method which can be deployed on the mobile device via server-assisted additive side-tuning. To further accelerate FT convergence and improve computing efficiency, PAE MobiLLM integrates activation caching on the server side, which allows the server to reuse historical activations and saves the mobile device from repeatedly computing forward passes for the recurring data samples. Besides, to reduce communication cost, PAE MobiLLM develops an activation shortcut that transmits only the token involved in the loss calculation instead of full activation matrices to guide the side network tuning. Last but not least, PAE MobiLLM introduces the additive adapter side-network design which makes the server train the adapter modules based on device-defined prediction differences rather than raw ground-truth labels. In this way, the server can only assist device-defined side-network computing, and learn nothing about data and labels. Extensive experimental results demonstrate PAE MobiLLM's superiority.

Large Language Model (LLM) at mobile devices and its potential applications never fail to fascinate. However, on-device LLM fine-tuning poses great challenges due to extremely high memory requirements and slow training speeds. Even with parameter-efficient fine-tuning (PEFT) methods that update only a small subset of parameters, resource-constrained mobile devices cannot afford them. In this paper, we propose MobiLLM to enable memory-efficient transformer LLM fine-tuning on a mobile device via server-assisted side-tuning. Particularly, MobiLLM allows the resource-constrained mobile device to retain merely a frozen backbone model, while offloading the memory and computation-intensive backpropagation of a trainable side-network to a high-performance server. Unlike existing fine-tuning methods that keep trainable parameters inside the frozen backbone, MobiLLM separates a set of parallel adapters from the backbone to create a backpropagation bypass, involving only one-way activation transfers from the mobile device to the server with low-width quantization during forward propagation. In this way, the data never leaves the mobile device while the device can remove backpropagation through the local backbone model and its forward propagation can be paralyzed with the server-side execution. Thus, MobiLLM preserves data privacy while significantly reducing the memory and computational burdens for LLM fine-tuning. Through extensive experiments, we demonstrate that MobiLLM can enable a resource-constrained mobile device, even a CPU-only one, to fine-tune LLMs and significantly reduce convergence time and memory usage.