This study presents a deep learning system for breast cancer detection in mammography, developed using a modified EfficientNetV2 architecture with enhanced attention mechanisms. The model was trained on mammograms from a major Thai medical center and validated on three distinct datasets: an in-domain test set (9,421 cases), a biopsy-confirmed set (883 cases), and an out-of-domain generalizability set (761 cases) collected from two different hospitals. For cancer detection, the model achieved AUROCs of 0.89, 0.96, and 0.94 on the respective datasets. The system's lesion localization capability, evaluated using metrics including Lesion Localization Fraction (LLF) and Non-Lesion Localization Fraction (NLF), demonstrated robust performance in identifying suspicious regions. Clinical validation through concordance tests showed strong agreement with radiologists: 83.5% classification and 84.0% localization concordance for biopsy-confirmed cases, and 78.1% classification and 79.6% localization concordance for out-of-domain cases. Expert radiologists' acceptance rate also averaged 96.7% for biopsy-confirmed cases, and 89.3% for out-of-domain cases. The system achieved a System Usability Scale score of 74.17 for source hospital, and 69.20 for validation hospitals, indicating good clinical acceptance. These results demonstrate the model's effectiveness in assisting mammogram interpretation, with the potential to enhance breast cancer screening workflows in clinical practice.

In this paper, a fine-tuning method of the parameters in the MMG model for the real-scale ship is proposed. In the proposed method, all of the arbitrarily indicated target parameters of the MMG model are tuned simultaneously in the framework of SI using time series data of real-sale ship maneuvering motion data to steadily improve the accuracy of the MMG model. Parameter tuning is formulated as a minimization problem of the deviation of the maneuvering motion simulated with given parameters and the real-scale ship trials, and the global solution is explored using CMA-ES. By constraining the exploration ranges to the neighborhood of the previously determined parameter values, the proposed method limits the output in a realistic range. The proposed method is applied to the tuning of 12 parameters for a container ship with five different widths of the exploration range. The results show that, in all cases, the accuracy of the maneuvering simulation is improved by applying the tuned parameters to the MMG model, and the validity of the proposed parameter fine-tuning method is confirmed.