Quantitative symbolic process models are proposed as a high-level model representation for probabilistic causal knowledge and know-how. These representations have suitable expressive power and mathematical foundation to serve as an abstraction of intelligence in much of AI research.

We provide preliminary evidence that eXlstmg algorithms for inferring small-scale gene regulation networks from gene expression data can be adapted to large-scale gene expression data coming from hybridization microarrays. The essential steps are (1) clustering many genes by their expression time-course data into a minimal set of clusters of co-expressed genes, (2) theoretically modeling the various conditions under which the time-courses are measured using a continious-time analog recurrent neural network for the cluster mean time-courses, (3) fitting such a regulatory model to the cluster mean time courses by simulated annealing with weight decay, and (4) analysing several such fits for commonalities in the circuit parameter sets including the connection matrices. This procedure can be used to assess the adequacy of existing and future gene expression time-course data sets for determ ining transcriptional regulatory relationships such as coregulation.

We provide preliminary evidence that eXlstmg algorithms for inferring small-scale gene regulation networks from gene expression data can be adapted to large-scale gene expression data coming from hybridization microarrays. The essential steps are (1) clustering many genes by their expression time-course data into a minimal set of clusters of co-expressed genes, (2) theoretically modeling the various conditions under which the time-courses are measured using a continious-time analog recurrent neural network for the cluster mean time-courses, (3) fitting such a regulatory model to the cluster mean time courses by simulated annealing with weight decay, and (4) analysing several such fits for commonalities in the circuit parameter sets including the connection matrices. This procedure can be used to assess the adequacy of existing and future gene expression time-course data sets for determ ining transcriptional regulatory relationships such as coregulation.

We provide preliminary evidence that eXlstmg algorithms for inferring small-scale gene regulation networks from gene expression data can be adapted to large-scale gene expression data coming from hybridization microarrays. The essential steps are (1) clustering many genes by their expression time-course data into a minimal set of clusters of co-expressed genes, (2) theoretically modeling the various conditions under which the time-courses are measured using a continious-time analog recurrent neural network for the cluster mean time-courses, (3) fitting such a regulatory model to the cluster mean time courses by simulated annealing with weight decay, and (4) analysing several such fits for commonalities in the circuit parameter sets including the connection matrices. This procedure can be used to assess the adequacy of existing and future gene expression time-course data sets for determ ining transcriptional regulatory relationships such as coregulation.

Many practical problems in computer vision, pattern recognition, robotics and other areas can be described in terms of constrained optimization. In the past decade, researchers have proposed means of solving such problems with the use of neural networks [Hopfield & Tank, 1985; Koch et ai., 1986], which are thus derived as relaxation dynamics for the objective functions codifying the optimization task. One disturbing aspect of the approach soon became obvious, namely the apparent inabilityof the methods to scale up to practical problems, the principal reason being the rapid increase in the number of local minima present in the objectives as the dimension of the problem increases. Moreover most objectives, E(v), are highly nonlinear, non-convex functions of v, and simple techniques (e.g.

The distance measure and learning problem are formally described as nested objective functions. We derive an efficient algorithm by using optimization techniques that allow us to divide up the objective function into parts which may be minimized in distinct phases. The algorithm has accurately recreated 10 prototypes from a randomly generated sample database of 100 images consisting of 20 points each in 120 experiments. Finally, by incorporating permutation invariance in our distance measure, we have a technique that we may be able to apply to the clustering of graphs. Our goal is to develop measures which will enable the learning of objects with shape or structure. Acknowledgements This work has been supported by AFOSR grant F49620-92-J-0465 and ONR/DARPA grant N00014-92-J-4048.

Model-based object recognition solves the problem of invariant recognition by relying on stored prototypes at unit scale positioned at the origin of an object-centered coordinate system. Elastic matching techniques are used to find a correspondence between features of the stored model and the data and can also compute the parameters of the transformation the observed instance has undergone relative to the stored model.

Two tightly coupled subproblems need to be solved for locating and recognizing the model: the correspondence problem (how are scene features put into correspondence with model features?),

Model-based object recognition solves the problem of invariant recognition by relying on stored prototypes at unit scale positioned at the origin of an object-centered coordinate system. Elastic matching techniques are used to find a correspondence between features of the stored model and the data and can also compute the parameters of the transformation the observed instance has undergone relative to the stored model.

Two tightly coupled subproblems need to be solved for locating and recognizing the model: the correspondence problem (how are scene features put into correspondence with model features?),