Speech synthesis from intracranial EEG (iEEG) signals offers a promising avenue for restoring communication in individuals with severe speech impairments. However, achieving intelligible and natural speech remains challenging due to limitations in feature representation, prosody modeling, and phase reconstruction. We introduce MiSTR, a deep-learning framework that integrates: 1) Wavelet-based feature extraction to capture fine-grained temporal, spectral, and neurophysiological representations of iEEG signals, 2) A Transformer-based decoder for prosody-aware spectrogram prediction, and 3) A neural phase vocoder enforcing harmonic consistency via adaptive spectral correction. Evaluated on a public iEEG dataset, MiSTR achieves state-of-the-art speech intelligibility, with a mean Pearson correlation of 0.91 between reconstructed and original Mel spectrograms, improving over existing neural speech synthesis baselines.

Tailoring treatments to individual needs is a central goal in fields such as medicine. A key step toward this goal is estimating Heterogeneous Treatment Effects (HTE) - the way treatments impact different subgroups. While crucial, HTE estimation is challenging with survival data, where time until an event (e.g., death) is key. Existing methods often assume complete observation, an assumption violated in survival data due to right-censoring, leading to bias and inefficiency. Cui et al. (2023) proposed a doubly-robust method for HTE estimation in survival data under no hidden confounders, combining a causal survival forest with an augmented inverse-censoring weighting estimator. However, we find it struggles under heavy censoring, which is common in rare-outcome problems such as Amyotrophic lateral sclerosis (ALS). Moreover, most current methods cannot handle instrumental variables, which are a crucial tool in the causal inference arsenal. We introduce Multiple Imputation for Survival Treatment Response (MISTR), a novel, general, and non-parametric method for estimating HTE in survival data. MISTR uses recursively imputed survival trees to handle censoring without directly modeling the censoring mechanism. Through extensive simulations and analysis of two real-world datasets-the AIDS Clinical Trials Group Protocol 175 and the Illinois unemployment dataset we show that MISTR outperforms prior methods under heavy censoring in the no-hidden-confounders setting, and extends to the instrumental variable setting. To our knowledge, MISTR is the first non-parametric approach for HTE estimation with unobserved confounders via instrumental variables.