Environment Animals Pets Dogs Pet dogs can help teens' mental health Breakthroughs, discoveries, and DIY tips sent every weekday. It's old news that having a dog provides a lot of benefits. Playing with a pooch can help our brains concentrate and relax, a family dog can help prevent food allergies in children, and even fulfill our primal need to nurture. They also may have some sway over some of the tiniest organisms around--the microbes that live in our bodies. A study published December 3 in the journal found that the family dog prompts changes in our gut microbiome that result in better mental health.

The gut contents act like a microscopic time machine into pre-Hispanic Mexico. Breakthroughs, discoveries, and DIY tips sent every weekday. Underneath the remains of an ancient young adult man and his preserved feces lies a microscopic world. These microorganisms beneath the cloth hold clues to what the world may have looked like hundreds of years ago. Now, a new look at a 1,000-year-old mummy called the Zimapán man could tell us what ancient Mesoamericans ate, where they lived, and show us how much our world has changed since.

Sepsis is a life-threatening condition which requires rapid diagnosis and treatment. Traditional microbiological methods are time-consuming and expensive. In response to these challenges, deep learning algorithms were developed to identify 14 bacteria species and 3 yeast-like fungi from microscopic images of Gram-stained smears of positive blood samples from sepsis patients. A total of 16,637 Gram-stained microscopic images were used in the study. The analysis used the Cellpose 3 model for segmentation and Attention-based Deep Multiple Instance Learning for classification. Our model achieved an accuracy of 77.15% for bacteria and 71.39% for fungi, with ROC AUC of 0.97 and 0.88, respectively. The highest values, reaching up to 96.2%, were obtained for Cutibacterium acnes, Enterococcus faecium, Stenotrophomonas maltophilia and Nakaseomyces glabratus. Classification difficulties were observed in closely related species, such as Staphylococcus hominis and Staphylococcus haemolyticus, due to morphological similarity, and within Candida albicans due to high morphotic diversity. The study confirms the potential of our model for microbial classification, but it also indicates the need for further optimisation and expansion of the training data set. In the future, this technology could support microbial diagnosis, reducing diagnostic time and improving the effectiveness of sepsis treatment due to its simplicity and accessibility. Part of the results presented in this publication was covered by a patent application at the European Patent Office EP24461637.1 "A computer implemented method for identifying a microorganism in a blood and a data processing system therefor".

Each year, snake bites kill upwards of 100,000 people and permanently disable hundreds of thousands more, according to estimates from the World Health Organization. Promising new science, enabled by state-of-the-art technology, could help quell the threat. Researchers have successfully designed two proteins to neutralize some of the most lethal venom toxins, using a suite of artificial intelligence tools, per a study published January 15 in the journal Nature. These "de novo" proteins–molecules not found anywhere in nature–protected 100% of mice from certain death when mixed with the deadly snake compounds and administered in lab experiments. "I think we could revolutionize the treatment [of snake bites]," says Susana Vázquez Torres, lead study author and a biochemist who completed this research as part of her doctoral thesis in David Baker's lab at the University of Washington.

So much of this year felt like a fever dream: The attempted assassination of Donald Trump. Which is why, this year, I'm leaning into my nerdish tendencies and rounding up some good, interesting, or inspiring news stories from the science world--promising discoveries, exciting new data, historic events, and unsung heroes. In the hope of providing relief from the hell that has been 2024, here's a non-comprehensive list of the year's coolest science stories, both big and small: Wildlife filmmaker Carlos Gauna and University of California, Riverside, PhD student Phillip Sternes spotted what appears to be a baby great white shark off the coast of California last year. In January, the team published the photos in the journal Environmental Biology of Fishes. "Where white sharks give birth is one of the holy grails of shark science. No one has ever been able to pinpoint where they are born, nor has anyone seen a newborn baby shark alive," Gauna said in a UC Riverside press release.

Large-Scale Multi-Agent Systems (LS-MAS) consist of several autonomous components, interacting in a non-trivial way, so that the emerging behaviour of the ensemble depends on the individual dynamics of the components and their reciprocal interactions. These models can describe a rich variety of natural systems, as well as artificial ones, characterised by unparalleled scalability, robustness, and flexibility. Indeed, a crucial objective is devising efficient strategies to model and control the spatial behaviours of LS-MAS to achieve specific goals. However, the inherent complexity of these systems and the wide spectrum of their emerging behaviours pose significant challenges. The overarching goal of this thesis is, therefore, to advance methods for modelling, analyzing and controlling the spatial behaviours of LS-MAS, with applications to cellular populations and swarm robotics. The thesis begins with an overview of the existing Literature, and is then organized into two distinct parts. In the context of swarm robotics, Part I deals with distributed control algorithms to spatially organize agents on geometric patterns. The contribution is twofold, encompassing both the development of original control algorithms, and providing a novel formal analysis, which allows to guarantee the emergence of specific geometric patterns. In Part II, looking at the spatial behaviours of biological agents, experiments are carried out to study the movement of microorganisms and their response to light stimuli. This allows the derivation and parametrization of mathematical models that capture these behaviours, and pave the way for the development of innovative approaches for the spatial control of microorganisms. The results presented in the thesis were developed by leveraging formal analytical tools, simulations, and experiments, using innovative platforms and original computational frameworks.

Traditional locomotion strategies become ineffective at low Reynolds numbers, where viscous forces predominate over inertial forces. To adapt, microorganisms have evolved specialized structures like cilia and flagella for efficient maneuvering in viscous environments. Among these organisms, Phytophthora zoospores demonstrate unique locomotion mechanisms that allow them to rapidly spread and attack new hosts while expending minimal energy. In this study, we present the design, fabrication, and testing of a zoospore-inspired robot, which leverages dual flexible flagella and oscillatory propulsion mechanisms to emulate the natural swimming behavior of zoospores. Our experiments and theoretical model reveal that both flagellar length and oscillation frequency strongly influence the robot's propulsion speed, with longer flagella and higher frequencies yielding enhanced performance. Additionally, the anterior flagellum, which generates a pulling force on the body, plays a dominant role in enhancing propulsion efficiency compared to the posterior flagellum's pushing force. This is a significant experimental finding, as it would be challenging to observe directly in biological zoospores, which spontaneously release the posterior flagellum when the anterior flagellum detaches. This work contributes to the development of advanced microscale robotic systems with potential applications in medical, environmental, and industrial fields. It also provides a valuable platform for studying biological zoospores and their unique locomotion strategies.

Digital twins (DTs) are revolutionizing the biotechnology industry by enabling sophisticated digital representations of biological assets, microorganisms, drug development processes, and digital health applications. However, digital twinning at micro and nano scales, particularly in modeling complex entities like bacteria, presents significant challenges in terms of requiring advanced Internet of Things (IoT) infrastructure and computing approaches to achieve enhanced accuracy and scalability. In this work, we propose a novel framework that integrates the Internet of Bio-Nano Things (IoBNT) with advanced machine learning techniques, specifically convolutional neural networks (CNN) and federated learning (FL), to effectively tackle the identified challenges. Within our framework, IoBNT devices are deployed to gather image-based biological data across various physical environments, leveraging the strong capabilities of CNNs for robust machine vision and pattern recognition. Subsequently, FL is utilized to aggregate insights from these disparate data sources, creating a refined global model that continually enhances accuracy and predictive reliability, which is crucial for the effective deployment of DTs in biotechnology. The primary contribution is the development of a novel framework that synergistically combines CNN and FL, augmented by the capabilities of the IoBNT. This novel approach is specifically tailored to enhancing DTs in the biotechnology industry. The results showcase enhancements in the reliability and safety of microorganism DTs, while preserving their accuracy. Furthermore, the proposed framework excels in energy efficiency and security, offering a user-friendly and adaptable solution. This broadens its applicability across diverse sectors, including biotechnology and pharmaceutical industries, as well as clinical and hospital settings.

Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine of Cornell University, New York, NY, USA Key Words Machine Learning Biosynthesis Artificial Neural Networks Enzyme pathway Deep Learning DBTL cycle ART Abstract In the modern world, technology is at its peak. Different avenues in programming and technology have been explored for data analysis, automation, and robotics. Machine learning is key to optimize data analysis, make accurate predictions, and hasten/improve existing functions. Thus, presently, the field of machine learning in artificial intelligence is being developed and its uses in varying fields are being explored. One field in which its uses stand out is that of microbial biosynthesis. In this paper, a comprehensive overview of the differing machine learning programs used in biosynthesis is provided, alongside brief descriptions of the fields of machine learning and microbial biosynthesis separately. This information includes past trends, modern developments, future improvements, explanations of processes, and current problems they face. Thus, this paper's main contribution is to distill developments in, and provide a holistic explanation of, 2 key fields and their applicability to improve industry/research. It also highlights challenges and research directions, acting to instigate more research and development in the growing fields. Finally, the paper aims to act as a reference for academics performing research, industry professionals improving their processes, and students looking to understand the concept of machine learning in biosynthesis. Introduction In 1944, the field of microbial biosynthesis was first established industrially, with the antibiotic penicillin being mass produced by a fungi belonging to the Penicillium genus.[1]

New dishwasher technology could soon save you money on water, electricity and detergent, a study reveals. Researchers have performed simulations of a dishwasher system that uses superheated steam instead of soap to clean dishes. Superheated steam is an extremely high-temperature vapour generated by heating the saturated steam obtained from boiling water. Results of computer simulations suggest that such a dishwasher would be able to kill 99 per cent of bacteria on one plate in just 25 seconds. As yet, the dishwasher only exists as a computer model, and not a physical object, but researchers say their study provides a basis for the development of next-generation dishwashers'.