Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram theory, which posits that sparse populations of neurons undergo lasting physical and biochemical changes to support long-term memory. Yet, a comprehensive computational framework that integrates biological findings with mechanistic models remains elusive. This work synthesizes insights from cellular neuroscience and computational modeling to address key challenges in engram research: how engram neurons are identified and manipulated; how synaptic plasticity mechanisms contribute to stable memory traces; and how sparsity promotes efficient, interference-resistant representations. Relevant computational approaches -- such as sparse regularization, engram gating, and biologically inspired architectures like Sparse Distributed Memory and spiking neural networks -- are also examined. Together, these findings suggest that memory efficiency, capacity, and stability emerge from the interaction of plasticity and sparsity constraints. By integrating neurobiological and computational perspectives, this paper provides a comprehensive theoretical foundation for engram research and proposes a roadmap for future inquiry into the mechanisms underlying memory, with implications for the diagnosis and treatment of memory-related disorders.

Welcome to our monthly digest, where you can catch up with any AIhub stories you may have missed, peruse the latest news, recap recent events, and more. This month, we hear about the latest research on soccer ball detection, learn about energy-based transformers, find out about memory traces in reinforcement learning, and explore some potential solutions to the problems with conference reviewing. Issues with the peer-review process, and pertaining to conferences in particular, are often discussed among authors, reviewers and conference chairs alike. However, coming up with potential solutions to the problem has proved challenging. Jaeho told us more in this interview .

Human brain achieves dynamic stability-plasticity balance through synaptic homeostasis. Inspired by this biological principle, we propose SPICED: a neuromorphic framework that integrates the synaptic homeostasis mechanism for unsupervised continual EEG decoding, particularly addressing practical scenarios where new individuals with inter-individual variability emerge continually. SPICED comprises a novel synaptic network that enables dynamic expansion during continual adaptation through three bio-inspired neural mechanisms: (1) critical memory reactivation; (2) synaptic consolidation and (3) synaptic renormalization. The interplay within synaptic homeostasis dynamically strengthens task-discriminative memory traces and weakens detrimental memories. By integrating these mechanisms with continual learning system, SPICED preferentially replays task-discriminative memory traces that exhibit strong associations with newly emerging individuals, thereby achieving robust adaptations. Meanwhile, SPICED effectively mitigates catastrophic forgetting by suppressing the replay prioritization of detrimental memories during long-term continual learning. Validated on three EEG datasets, SPICED show its effectiveness.

The T-maze, shown below, is a prototypical example of a task studied in the field of reinforcement learning. An artificial agent enters the maze from the left and immediately receives one of two possible observations: red or green. Red means that the agent will be rewarded for moving to the top at the right end of the corridor (in the question mark tile), while green means the opposite: the agent will be rewarded for moving down. While this seems like a trivial task, modern machine learning algorithms (such as Q-learning) fail at learning the desired behavior. This is because these algorithms are designed to solve (MDPs).

Partially observable environments present a considerable computational challenge in reinforcement learning due to the need to consider long histories. Learning with a finite window of observations quickly becomes intractable as the window length grows. In this work, we introduce memory traces. Inspired by eligibility traces, these are compact representations of the history of observations in the form of exponential moving averages. We prove sample complexity bounds for the problem of offline on-policy evaluation that quantify the value errors achieved with memory traces for the class of Lipschitz continuous value estimates. We establish a close connection to the window approach, and demonstrate that, in certain environments, learning with memory traces is significantly more sample efficient. Finally, we underline the effectiveness of memory traces empirically in online reinforcement learning experiments for both value prediction and control.

The autonomous learning of new goals in robotics remains a complex issue to address. Here, we propose a model where curiosity influence learning flexibility. To do so, this paper proposes to root curiosity and attention together by taking inspiration from the Locus Coeruleus-Norepinephrine system along with various cognitive processes such as cognitive persistence and visual habituation. We apply our approach by experimenting with a simulated robotic arm on a set of objects with varying difficulty. The robot first discovers new goals via bottom-up attention through motor babbling with an inhibition of return mechanism, then engage to the learning of goals due to neural activity arising within the curiosity mechanism. The architecture is modelled with dynamic neural fields and the learning of goals such as pushing the objects in diverse directions is supported by the use of forward and inverse models implemented by multi-layer perceptrons. The adoption of dynamic neural fields to model curiosity, habituation and persistence allows the robot to demonstrate various learning trajectories depending on the object. In addition, the approach exhibits interesting properties regarding the learning of similar goals as well as the continuous switch between exploration and exploitation.

Memory traces--changes in the memory system that result from the perception and encoding of an event--were measured in pioneering studies by Endel Tulving and Michael J. Watkins in 1975. These and further experiments informed the maturation of Tulving's memory model, from the GAPS (General Abstract Processing System} to the SPI (Serial-Parallel Independent) model. Having current top of the line LLMs revisit the original Tulving-Watkins tests may help in assessing whether foundation models completely instantiate or not this class of psychological models.

Recent proposals suggest that large, generic neuronal networks could store memory traces of past input sequences in their instantaneous state. Such a proposal raises important theoretical questions about the duration of these memory traces and their dependence on network size, connectivity and signal statistics. Prior work, in the case of gaussian input sequences and linear neuronal networks, shows that the duration of memory traces in a network cannot exceed the number of neurons (in units of the neuronal time constant), and that no network can out-perform an equivalent feedforward network. However a more ethologically relevant scenario is that of sparse input sequences. In this scenario, we show how linear neural networks can essentially perform compressed sensing (CS) of past inputs, thereby attaining a memory capacity that exceeds the number of neurons. This enhanced capacity is achieved by a class of "orthogonal" recurrent networks and not by feedforward networks or generic recurrent networks. We exploit techniques from the statistical physics of disordered systems to analytically compute the decay of memory traces in such networks as a function of network size, signal sparsity and integration time. Alternately, viewed purely from the perspective of CS, this work introduces a new ensemble of measurement matrices derived from dynamical systems, and provides a theoretical analysis of their asymptotic performance.

Recent proposals suggest that large, generic neuronal networks could store memory traces of past input sequences in their instantaneous state. Such a proposal raises important theoretical questions about the duration of these memory traces and their dependence on network size, connectivity and signal statistics. Prior work, in the case of gaussian input sequences and linear neuronal networks, shows that the duration of memory traces in a network cannot exceed the number of neurons (in units of the neuronal time constant), and that no network can out-perform an equivalent feedforward network. However a more ethologically relevant scenario is that of sparse input sequences. In this scenario, we show how linear neural networks can essentially perform compressed sensing (CS) of past inputs, thereby attaining a memory capacity that {\it exceeds} the number of neurons. This enhanced capacity is achieved by a class of orthogonal recurrent networks and not by feedforward networks or generic recurrent networks.

Recurrent neural networks are used to forecast time series in finance, climate, language, and from many other domains. Reservoir computers are a particularly easily trainable form of recurrent neural network. Recently, a "next-generation" reservoir computer was introduced in which the memory trace involves only a finite number of previous symbols. We explore the inherent limitations of finite-past memory traces in this intriguing proposal. A lower bound from Fano's inequality shows that, on highly non-Markovian processes generated by large probabilistic state machines, next-generation reservoir computers with reasonably long memory traces have an error probability that is at least ~ 60% higher than the minimal attainable error probability in predicting the next observation. More generally, it appears that popular recurrent neural networks fall far short of optimally predicting such complex processes. These results highlight the need for a new generation of optimized recurrent neural network architectures. Alongside this finding, we present concentration-of-measure results for randomly-generated but complex processes. One conclusion is that large probabilistic state machines -- specifically, large $\epsilon$-machines -- are key to generating challenging and structurally-unbiased stimuli for ground-truthing recurrent neural network architectures.