Sign on the back of a vehicle pleading for someone to donate a kidney to a sick man in Mississauga, ... [ ] Ontario, Canada. In March 2020, there were more than 110,000 people on the national transplant waiting list. According to the U.S. Government Information on Organ Donation and Transplantation, 20 people die every day while waiting for an organ donor transplant. And every nine minutes, someone is added to the national transplant list. In 2019, 39,718 transplant operations were performed, which was a record high for the seventh consecutive year.

CCI is an algorithm which discovers causation from observational data. More specifically, it is a constraint-based algorithm for causal discovery with cycles, latent variables and/or selection bias. Running CCI feels like running FCI, but CCI can handle cycles. CCI discovers a partially oriented maximal almost ancestral graph (MAAG) of some directed graph G, provided that the global Markov property and d-separation faithfulness holds according to G. Such properties are reasonable when G is the directed graph of a structural equation model with independent errors and linearity holds, for example.