Large Language Models (LLMs) hallucinate, and detecting these cases is key to ensuring trust. While many approaches address hallucination detection at the response or span level, recent work explores token-level detection, enabling more fine-grained intervention. However, the distribution of hallucination signal across sequences of hallucinated tokens remains unexplored. We leverage token-level annotations from the RAGTruth corpus and find that the first hallucinated token is far more detectable than later ones. This structural property holds across models, suggesting that first hallucination tokens play a key role in token-level hallucination detection. Our code is available at https://github.com/jakobsnl/RAGTruth_Xtended.

This paper introduces PersonaAI, a cutting-edge application that leverages Retrieval-Augmented Generation (RAG) and the LLAMA model to create highly personalized digital avatars capable of accurately mimicking individual personalities. Designed as a cloud-based mobile application, PersonaAI captures user data seamlessly, storing it in a secure database for retrieval and analysis. The result is a system that provides context-aware, accurate responses to user queries, enhancing the potential of AI-driven personalization. Why should you care? PersonaAI combines the scalability of RAG with the efficiency of prompt-engineered LLAMA3, offering a lightweight, sustainable alternative to traditional large language model (LLM) training methods. The system's novel approach to data collection, utilizing real-time user interactions via a mobile app, ensures enhanced context relevance while maintaining user privacy. By open-sourcing our implementation, we aim to foster adaptability and community-driven development. PersonaAI demonstrates how AI can transform interactions by merging efficiency, scalability, and personalization, making it a significant step forward in the future of digital avatars and personalized AI.

This paper presents a novel approach to epidemic surveillance, leveraging the power of Artificial Intelligence and Large Language Models (LLMs) for effective interpretation of unstructured big data sources, like the popular ProMED and WHO Disease Outbreak News. We explore several LLMs, evaluating their capabilities in extracting valuable epidemic information. We further enhance the capabilities of the LLMs using in-context learning, and test the performance of an ensemble model incorporating multiple open-source LLMs. The findings indicate that LLMs can significantly enhance the accuracy and timeliness of epidemic modelling and forecasting, offering a promising tool for managing future pandemic events.

We propose a new method, instruction back-and-forth translation, to construct high-quality synthetic data grounded in world knowledge for aligning large language models (LLMs). Given documents from a web corpus, we generate and curate synthetic instructions using the backtranslation approach proposed by Li et al.(2023a), and rewrite the responses to improve their quality further based on the initial documents. Fine-tuning with the resulting (backtranslated instruction, rewritten response) pairs yields higher win rates on AlpacaEval than using other common instruction datasets such as Humpback, ShareGPT, Open Orca, Alpaca-GPT4 and Self-instruct. We also demonstrate that rewriting the responses with an LLM outperforms direct distillation, and the two generated text distributions exhibit significant distinction in embedding space. Further analysis shows that our backtranslated instructions are of higher quality than other sources of synthetic instructions, while our responses are more diverse and complex than those obtained from distillation. Overall we find that instruction back-and-forth translation combines the best of both worlds -- making use of the information diversity and quantity found on the web, while ensuring the quality of the responses which is necessary for effective alignment.

The rapid growth of biomedical knowledge has outpaced our ability to efficiently extract insights and generate novel hypotheses. Large language models (LLMs) have emerged as a promising tool to revolutionize knowledge interaction and potentially accelerate biomedical discovery. In this paper, we present a comprehensive evaluation of LLMs as biomedical hypothesis generators. We construct a dataset of background-hypothesis pairs from biomedical literature, carefully partitioned into training, seen, and unseen test sets based on publication date to mitigate data contamination. Using this dataset, we assess the hypothesis generation capabilities of top-tier instructed models in zero-shot, few-shot, and fine-tuning settings. To enhance the exploration of uncertainty, a crucial aspect of scientific discovery, we incorporate tool use and multi-agent interactions in our evaluation framework. Furthermore, we propose four novel metrics grounded in extensive literature review to evaluate the quality of generated hypotheses, considering both LLM-based and human assessments. Our experiments yield two key findings: 1) LLMs can generate novel and validated hypotheses, even when tested on literature unseen during training, and 2) Increasing uncertainty through multi-agent interactions and tool use can facilitate diverse candidate generation and improve zero-shot hypothesis generation performance. However, we also observe that the integration of additional knowledge through few-shot learning and tool use may not always lead to performance gains, highlighting the need for careful consideration of the type and scope of external knowledge incorporated. These findings underscore the potential of LLMs as powerful aids in biomedical hypothesis generation and provide valuable insights to guide further research in this area.

Large language models (LLMs) can spend extra compute during inference to generate intermediate thoughts, which helps to produce better final responses. Since Chain-of-Thought (Wei et al., 2022), many such System 2 techniques have been proposed such as Rephrase and Respond (Deng et al., 2023a), System 2 Attention (Weston and Sukhbaatar, 2023) and Branch-Solve-Merge (Saha et al., 2023). In this work we investigate self-supervised methods to ``compile'' (distill) higher quality outputs from System 2 techniques back into LLM generations without intermediate reasoning token sequences, as this reasoning has been distilled into System 1. We show that several such techniques can be successfully distilled, resulting in improved results compared to the original System 1 performance, and with less inference cost than System 2. We posit that such System 2 distillation will be an important feature of future continually learning AI systems, enabling them to focus System 2 capabilities on the reasoning tasks that they cannot yet do well.

Large language models (LLMs) have demonstrated multilingual capabilities; yet, they are mostly English-centric due to the imbalanced training corpora. Existing works leverage this phenomenon to improve their multilingual performances through translation, primarily on natural language processing (NLP) tasks. This work extends the evaluation from NLP tasks to real user queries and from English-centric LLMs to non-English-centric LLMs. While translation into English can help improve the performance of multilingual NLP tasks for English-centric LLMs, it may not be optimal for all scenarios. For culture-related tasks that need deep language understanding, prompting in the native language tends to be more promising as it better captures the nuances of culture and language. Our experiments reveal varied behaviors among different LLMs and tasks in the multilingual context. Therefore, we advocate for more comprehensive multilingual evaluation and more efforts toward developing multilingual LLMs beyond English-centric ones.

Cancer stage classification is important for making treatment and care management plans for oncology patients. Information on staging is often included in unstructured form in clinical, pathology, radiology and other free-text reports in the electronic health record system, requiring extensive work to parse and obtain. To facilitate the extraction of this information, previous NLP approaches rely on labeled training datasets, which are labor-intensive to prepare. In this study, we demonstrate that without any labeled training data, open-source clinical large language models (LLMs) can extract pathologic tumor-node-metastasis (pTNM) staging information from real-world pathology reports. Our experiments compare LLMs and a BERT-based model fine-tuned using the labeled data. Our findings suggest that while LLMs still exhibit subpar performance in Tumor (T) classification, with the appropriate adoption of prompting strategies, they can achieve comparable performance on Metastasis (M) classification and improved performance on Node (N) classification.

Despite their effectiveness, the high costs associated with their use pose a challenge. We present LlamBERT, a hybrid approach that leverages LLMs to annotate a small subset of large, unlabeled databases and uses the results for fine-tuning transformer encoders like BERT and RoBERTa. This strategy is evaluated on two diverse datasets: the IMDb review dataset and the UMLS Meta-Thesaurus. Our results indicate that the LlamBERT approach slightly compromises on accuracy while offering much greater cost-effectiveness.

Large Language Models (LLMs) have unlocked new capabilities and applications; however, evaluating the alignment with human preferences still poses significant challenges. To address this issue, we introduce Chatbot Arena, an open platform for evaluating LLMs based on human preferences. Our methodology employs a pairwise comparison approach and leverages input from a diverse user base through crowdsourcing. The platform has been operational for several months, amassing over 240K votes. This paper describes the platform, analyzes the data we have collected so far, and explains the tried-and-true statistical methods we are using for efficient and accurate evaluation and ranking of models. We confirm that the crowdsourced questions are sufficiently diverse and discriminating and that the crowdsourced human votes are in good agreement with those of expert raters. These analyses collectively establish a robust foundation for the credibility of Chatbot Arena. Because of its unique value and openness, Chatbot Arena has emerged as one of the most referenced LLM leaderboards, widely cited by leading LLM developers and companies. Our demo is publicly available at \url{https://chat.lmsys.org}.